scholarly journals Autophagy activation reduces renal tubular injury induced by urinary proteins

Autophagy ◽  
2013 ◽  
Vol 10 (2) ◽  
pp. 243-256 ◽  
Author(s):  
Wei Jing Liu ◽  
Mian-Na Luo ◽  
Jin Tan ◽  
Wei Chen ◽  
Lei-zhao Huang ◽  
...  
Keyword(s):  
Tubular Injury ◽  
Urinary Proteins ◽  
Renal Tubular

470-P: SIK2 Protects against Renal Tubular Injury by Inhibiting Endoplasmic Reticulum Stress

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 470-P
Author(s):  
XIAOYU LIAO ◽  
BINGYAO LIU ◽  
HONGTING ZHENG
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Tubular Injury ◽  
Renal Tubular

scholarly journals An Immunohistochemical Investigation of Renal Phospholipidosis and Toxicity in Rats

2017 ◽  
Vol 36 (5) ◽  
pp. 386-394 ◽  
Author(s):  
Jing Ying Ma ◽  
Sandra Snook ◽  
Sheryl Garrovillo ◽  
Charles Johnson ◽  
David La
Keyword(s):  
Electron Microscopy ◽  
Membrane Protein ◽  
Kidney Injury ◽  
Tubular Epithelial Cell ◽  
Vehicle Group ◽  
Tubular Injury ◽  
Histamine H4 Receptor ◽  
Outer Stripe ◽  
H4 Receptor ◽  
Renal Tubular

Immunohistochemical staining for the lysosome-associated membrane protein 2 (LAMP-2) has been proposed previously as an alternative to electron microscopy to identify hepatic phospholipidosis. This study used LAMP-2 immunohistochemistry (IHC) to diagnose phospholipidosis in rats exhibiting renal tubular injury. Rats were administered toreforant, a histamine H4 receptor antagonist by oral gavage at a dose of 3, 10, or 100 mg/kg/d for 6 months. Hematoxylin and eosin staining revealed renal tubular epithelial cell vacuolation, hypertrophy, degeneration, and luminal dilation in the 100 mg/kg/d group animals. Renal tubular injury was confirmed using kidney injury marker 1 (KIM-1) IHC. The involvement of phosopholipidosis in the renal injury was investigated by LAMP-2. Adipophilin IHC was included to differentiate phospholipidosis from lipidosis. Increased LAMP-2 staining was observed in the 100 mg/kg/d group animals when compared to vehicle group animals. Lysosome-associated membrane protein-2 staining was most prominent in the outer stripe of the outer medulla where KIM-1 staining was also most prominent. By contrast, adipophilin staining was not increased. Phospholipidosis was also confirmed by electron microscopy. These data support the use of LAMP-2 IHC as a diagnostic tool and suggest an association between phospholipidosis and the renal tubular injury caused by toreforant.

Serial changes in urinary cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies

2008 ◽  
Vol 176 (2) ◽  
pp. 124-130 ◽  
Author(s):  
Etsuko Kobayashi ◽  
Yasushi Suwazono ◽  
Ryumon Honda ◽  
Mirei Dochi ◽  
Muneko Nishijo ◽  
...  
Keyword(s):  
Rice Paddies ◽  
Tubular Injury ◽  
Urinary Cadmium ◽  
Renal Tubular

SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis

2016 ◽  
Vol 83 ◽  
pp. 41-50 ◽  
Author(s):  
Xue-ling Wang ◽  
Li-yan Wu ◽  
Long Zhao ◽  
Li-na Sun ◽  
Hai-ying Liu ◽  
...  
Keyword(s):  
Tubular Injury ◽  
Renal Tubular ◽  
Sirt1 Activator

scholarly journals Genetic Polymorphisms of MnSOD Modify the Impacts of Environmental Melamine on Oxidative Stress and Early Kidney Injury in Calcium Urolithiasis Patients

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 152
Author(s):  
Chia-Chu Liu ◽  
Chia-Fang Wu ◽  
Yung-Chin Lee ◽  
Tsung-Yi Huang ◽  
Shih-Ting Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Manganese Superoxide Dismutase ◽  
Kidney Injury ◽  
Normal Function ◽  
Nucleotide Polymorphisms ◽  
Tubular Injury ◽  
Single Nucleotide ◽  
Manganese Superoxide ◽  
Calcium Urolithiasis ◽  
Renal Tubular

Environmental melamine exposure increases the risks of oxidative stress and early kidney injury. Manganese superoxide dismutase (MnSOD), glutathione peroxidase, and catalase can protect the kidneys against oxidative stress and maintain normal function. We evaluated whether their single-nucleotide polymorphisms (SNPs) could modify melamine’s effects. A total of 302 patients diagnosed with calcium urolithiasis were enrolled. All patients provided one-spot overnight urine samples to measure their melamine levels, urinary biomarkers of oxidative stress and renal tubular injury. Median values were used to dichotomize levels into high and low. Subjects carrying the T allele of rs4880 and high melamine levels had 3.60 times greater risk of high malondialdehyde levels than those carrying the C allele of rs4880 and low melamine levels after adjustment. Subjects carrying the G allele of rs5746136 and high melamine levels had 1.73 times greater risk of high N-Acetyl-β-d-glucosaminidase levels than those carrying the A allele of rs5746136 and low melamine levels. In conclusion, the SNPs of MnSOD, rs4880 and rs5746136, influence the risk of oxidative stress and renal tubular injury, respectively, in calcium urolithiasis patients. In the context of high urinary melamine levels, their effects on oxidative stress and renal tubular injury were further increased.

scholarly journals Impaired Na+−K+-ATPase signaling in renal proximal tubule contributes to hyperuricemia-induced renal tubular injury

2018 ◽  
Vol 50 (3) ◽  
pp. e452-e452 ◽  
Author(s):  
Jing Xiao ◽  
Xiaoli Zhang ◽  
Chensheng Fu ◽  
Qingmei Yang ◽  
Ying Xie ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Renal Proximal Tubule ◽  
Tubular Injury ◽  
Renal Tubular

scholarly journals FP369ACF-TEI, a novel uremic toxin absorbent, has superior adsorption profiles and suppresses renal tubular injury induced by uremic toxins

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Toshiya Mashiko ◽  
Takashi Shirakura ◽  
Hiroshi Shimoyama ◽  
Yasumi Nishiwaki ◽  
Kumiko Aoki ◽  
...  
Keyword(s):  
Uremic Toxins ◽  
Uremic Toxin ◽  
Tubular Injury ◽  
Renal Tubular

Urine markers of renal tubular injury in idiopathic membranous nephropathy: A cross sectional study

2019 ◽  
Vol 492 ◽  
pp. 7-11 ◽  
Author(s):  
Changjuan An ◽  
Gilbert Akankwasa ◽  
Jianhua Liu ◽  
Dandan Wang ◽  
Guixue Cheng ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Cross Sectional Study ◽  
Idiopathic Membranous Nephropathy ◽  
Sectional Study ◽  
Tubular Injury ◽  
Cross Sectional ◽  
Renal Tubular ◽  
Urine Markers
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