ORAL VERSUS TRANSDERMAL ESTROGEN IN TURNER SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS

2017 ◽  
Vol 23 (4) ◽  
pp. 408-421 ◽  
Author(s):  
Feras Zaiem ◽  
Fares Alahdab ◽  
Alaa Al Nofal ◽  
Mohammad Hassan Murad ◽  
Asma Javed
Keyword(s):  
Systematic Review ◽  
Turner Syndrome ◽  
Meta Analysis ◽  
Transdermal Estrogen

Effect of estrogen replacement therapy on bone and cardiovascular outcomes in women with turner syndrome: a systematic review and meta-analysis

Endocrine ◽  
2016 ◽  
Vol 55 (2) ◽  
pp. 366-375 ◽  
Author(s):  
Dahima Cintron ◽  
Rene Rodriguez-Gutierrez ◽  
Valentina Serrano ◽  
Paula Latortue-Albino ◽  
Patricia J Erwin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Replacement Therapy ◽  
Turner Syndrome ◽  
Estrogen Replacement Therapy ◽  
Meta Analysis ◽  
Cardiovascular Outcomes ◽  
Estrogen Replacement

scholarly journals Strength of the association between Turner syndrome and coeliac disease: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e037478
Author(s):  
Ghada S M Al-Bluwi ◽  
Asma H Alnababteh ◽  
Saif Al-Shamsi ◽  
Rami H Al-Rifai
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Coeliac Disease ◽  
Turner Syndrome ◽  
Meta Analysis ◽  
Healthcare Providers ◽  
Autoimmune Disorder ◽  
Epidemiological Studies ◽  
Eligibility Criteria ◽  
Chromosomal Disorders

IntroductionCoeliac disease (CD) is a genetic autoimmune disorder characterised by a permanent sensitivity to the gluten contained in some grains. Certain patient groups are considered high risk for the development of CD, including, but not limited to, those with chromosomal disorders such as Turner syndrome (TS). Here, we present a protocol for a systematic review and meta-analysis that aims to comprehensively summarise the literature, and quantitatively estimate the weighted strength of the association between TS and CD.Methods and analysisOur protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines. We will search PubMed, Scopus, Web of Science and Embase databases for relevant articles. Variant and broad search terms will be selected for identifying epidemiological studies reporting on the crude and/or adjusted association between TS and CD. Retrieved citations will be screened, and data from the eligible research reports against specific eligibility criteria will be extracted. We will then assess the risk of bias associated with the eligible studies using the Newcastle-Ottawa Scale. The overall weighted strength of the pooled association will be quantified using the random-effects model.Ethics and disseminationThis review will use data from published literature; hence, ethical approval will not be needed. The resulting review will be the first to produce a comprehensive synthesis of the strength of the association between TS and CD. The results will be disseminated through a peer-reviewed journal as well as in local and international conferences and symposiums. Results dissemination would help healthcare providers and policy-makers to make informed decisions regarding the diagnosis and management of CD in high-risk individuals.PROSPERO registration numberCRD42019131881, dated 3 September 2019.

scholarly journals Prevalence of Celiac Disease in Patients With Turner Syndrome: Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ghada S. M. Al-Bluwi ◽  
Asma H. AlNababteh ◽  
Linda Östlundh ◽  
Saif Al-Shamsi ◽  
Rami H. Al-Rifai
Keyword(s):  
Systematic Review ◽  
Celiac Disease ◽  
Turner Syndrome ◽  
Odds Ratio ◽  
Rate Ratio ◽  
Meta Analysis ◽  
Autoimmune Disorder ◽  
Prevalence Rates ◽  
Eligibility Criteria ◽  
Strength Of Association

Introduction: Celiac disease (CD) is a multifactorial autoimmune disorder, and studies have reported that patients with Turner syndrome (TS) are at risk for CD. This systematic review and meta-analysis aimed to quantify the weighted prevalence of CD among patients with TS and determine the weighted strength of association between TS and CD.Methods: Studies published between January 1991 and December 2019 were retrieved from four electronic databases: PubMed, Scopus, Web of Science, and Embase. Eligible studies were identified and relevant data were extracted by two independent reviewers following specific eligibility criteria and a data extraction plan. Using the random-effects model, the pooled, overall and subgroup CD prevalence rates were determined, and sources of heterogeneity were investigated using meta-regression.Results: Among a total of 1,116 screened citations, 36 eligible studies were included in the quantitative synthesis. Nearly two-thirds of the studies (61.1%) were from European countries. Of the 6,291 patients with TS who were tested for CD, 241 were diagnosed with CD, with a crude CD prevalence of 3.8%. The highest and lowest CD prevalence rates of 20.0 and 0.0% were reported in Sweden and Germany, respectively. The estimated overall weighted CD prevalence was 4.5% (95% confidence interval [CI], 3.3–5.9, I2, 67.4%). The weighted serology-based CD prevalence in patients with TS (3.4%, 95% CI, 1.0–6.6) was similar to the weighted biopsy-based CD prevalence (4.8%; 95% CI, 3.4–6.5). The strength of association between TS and CD was estimated in only four studies (odds ratio 18.1, 95% CI, 1.82–180; odds ratio 4.34, 95% CI, 1.48–12.75; rate ratio 14, 95% CI, 1.48–12.75; rate ratio 42.5, 95% CI, 12.4–144.8). Given the lack of uniformity in the type of reported measures of association and study design, producing a weighted effect measure to evaluate the strength of association between TS and CD was unfeasible.Conclusion: Nearly 1 in every 22 patients with TS had CD. Regular screening for CD in patients with TS might facilitate early diagnosis and therapeutic management to prevent adverse effects of CD such as being underweight and osteoporosis.

scholarly journals Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 28 (2) ◽  
pp. 188-215 ◽  
Author(s):  
Claire Mauger ◽  
Céline Lancelot ◽  
Arnaud Roy ◽  
Régis Coutant ◽  
Nicole Cantisano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Executive Functions ◽  
Children And Adolescents ◽  
Turner Syndrome ◽  
Meta Analysis

scholarly journals Oral vs Transdermal Estrogen Therapy and Vascular Events: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 100 (11) ◽  
pp. 4012-4020 ◽  
Author(s):  
Khaled Mohammed ◽  
Abd Moain Abu Dabrh ◽  
Khalid Benkhadra ◽  
Alaa Al Nofal ◽  
Barbara G. Carranza Leon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Estrogen Therapy ◽  
Vascular Events ◽  
Transdermal Estrogen

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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