Insulin-Like Growth Factors, Insulin, and Growth Hormone Signaling in Breast Cancer: Implications for Targeted Therapy

2014 ◽  
Vol 20 (11) ◽  
pp. 1214-1221 ◽  
Author(s):  
Heather Beckwith ◽  
Douglas Yee
Keyword(s):  
Breast Cancer ◽  
Growth Hormone ◽  
Growth Factors ◽  
Targeted Therapy ◽  
Hormone Signaling ◽  
Insulin Like Growth Factors

Human fetal and adult chondrocytes: effect of insulin-like growth factors I and II, insulin and growth hormone on clonal growth

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S124
Author(s):  
U. VETTER ◽  
J. ZAPF ◽  
W. HEIT ◽  
E. HEINZE ◽  
R.E. FROESCH ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Clonal Growth ◽  
Insulin Like Growth Factors

The Potential Role of Insulin-Like Growth Factors in Skeletal Muscle Regeneration

1996 ◽  
Vol 21 (4) ◽  
pp. 236-250 ◽  
Author(s):  
Jamie MacGregor ◽  
Wade S. Parkhouse
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Growth Factors ◽  
Muscle Regeneration ◽  
Potential Role ◽  
Tissue Growth ◽  
Skeletal Muscle Regeneration ◽  
Tissue Type ◽  
Insulin Like Growth Factors

The role of the insulin-like growth factors I and II (IGF-I and IGF-II), previously known as the somatomedins, in general growth and development of various tissues has been known for many years. Thought of exclusively as endocrine factors produced by the liver, and under the control of growth hormone, the somatomedins were known as the intermediaries by which growth hormone exerted its cellular effects during tissue growth and maturation. Eventually it was discovered that virtually every tissue type is capable of autocrine production of the IGFs, and their involvement in skeletal muscle tissue repair and regeneration became apparent. Recent advances in technology have allowed the characterisation of many of the different growth factors believed to play a role in muscle regeneration, and experimental manipulations of cells in culture have provided insight into the effects of the various growth factors on the myoblast. This paper explores the potential role of the IGFs in skeletal muscle regeneration. A critical role of IGF-II in terminal differentiation of proliferating muscle precurser cells following injury is proposed. Key words: growth factors, myogenesis, skeletal muscle regeneration

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