Preserved Proinsulin Production in Homozygous Protein Tyrosine Phosphatase Nonreceptor Type 22 C1858T Variant Type 1 Diabetes: A Possible Explanation for Absence of Overt Ketoacidosis Despite Omission of Exogenous Insulin

Devin Steenkamp; Jeff Milunsky; Elliot Sternthal

doi:10.4158/ep12286.or

Preserved Proinsulin Production in Homozygous Protein Tyrosine Phosphatase Nonreceptor Type 22 C1858T Variant Type 1 Diabetes: A Possible Explanation for Absence of Overt Ketoacidosis Despite Omission of Exogenous Insulin

Endocrine Practice ◽

10.4158/ep12286.or ◽

2013 ◽

Vol 19 (3) ◽

pp. 426-430 ◽

Cited By ~ 2

Author(s):

Devin Steenkamp ◽

Jeff Milunsky ◽

Elliot Sternthal

Keyword(s):

Type 1 Diabetes ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Exogenous Insulin ◽

Protein Tyrosine ◽

Variant Type

Download Full-text

Value of Antibodies to Islet Protein Tyrosine Phosphatase-Like Molecule in Predicting Type 1 Diabetes

Diabetes ◽

10.2337/diab.46.8.1270 ◽

1997 ◽

Vol 46 (8) ◽

pp. 1270-1275 ◽

Cited By ~ 41

Author(s):

M. Hawa ◽

R. Rowe ◽

M. S. Lan ◽

A. L. Notkins ◽

P. Pozzilli ◽

...

Keyword(s):

Type 1 Diabetes ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine

Download Full-text

An Islet-Cell Protein Tyrosine Phosphatase Is a Likely Precursor to the 37-kDa Autoantigen in Type 1 Diabetes: Human and Macaque Sequences, Tissue Distribution, Unique and Shared Epitopes, and Predictive Autoantibodies

Molecular Medicine ◽

10.1007/bf03401670 ◽

1997 ◽

Vol 3 (3) ◽

pp. 163-173 ◽

Cited By ~ 7

Author(s):

James LaGasse ◽

Laura Jelinek ◽

Shannon Sexson ◽

Cathy Lofton-Day ◽

John Breininger ◽

...

Keyword(s):

Type 1 Diabetes ◽

Tissue Distribution ◽

Protein Tyrosine Phosphatase ◽

Islet Cell ◽

Tyrosine Phosphatase ◽

Cell Protein ◽

Protein Tyrosine ◽

Shared Epitopes

Download Full-text

Population-based and family-based studies on the protein tyrosine phosphatase non-receptor 22 gene polymorphism and type 1 diabetes: A meta-analysis

Gene ◽

10.1016/j.gene.2012.12.076 ◽

2013 ◽

Vol 517 (2) ◽

pp. 191-196 ◽

Cited By ~ 6

Author(s):

Xiao-Feng Wang ◽

Zi-Xian Chen ◽

Yun-Chao Shao ◽

Yu-Shui Ma ◽

Feng Zhang ◽

...

Keyword(s):

Type 1 Diabetes ◽

Gene Polymorphism ◽

Protein Tyrosine Phosphatase ◽

Meta Analysis ◽

Tyrosine Phosphatase ◽

Population Based ◽

Protein Tyrosine ◽

Family Based

Download Full-text

Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population

Tissue Antigens ◽

10.1111/j.1399-0039.2010.01480.x ◽

2010 ◽

Cited By ~ 1

Author(s):

P. C. Chagastelles ◽

M. Romitti ◽

M. R. Trein ◽

E. Bandinelli ◽

B. Tschiedel ◽

...

Keyword(s):

Type 1 Diabetes ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Brazilian Population ◽

Protein Tyrosine ◽

1858T Allele

Download Full-text

Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study

Journal of Medical Genetics ◽

10.1136/jmg.2004.026971 ◽

2005 ◽

Vol 42 (3) ◽

pp. 266-270 ◽

Cited By ~ 49

Author(s):

H Qu

Keyword(s):

Type 1 Diabetes ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Family Based

Download Full-text

Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs

PLoS ONE ◽

10.1371/journal.pone.0198652 ◽

2018 ◽

Vol 13 (6) ◽

pp. e0198652 ◽

Cited By ~ 4

Author(s):

Mohammad Z. Haider ◽

Majedah A. Rasoul ◽

Maria Al-Mahdi ◽

Hessa Al-Kandari ◽

Gursev S. Dhaunsi

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Receptor Type ◽

Protein Tyrosine ◽

Hla Dq ◽

Functional Variant

Download Full-text

Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes

Diabetes ◽

10.2337/diabetes.46.8.1270 ◽

1997 ◽

Vol 46 (8) ◽

pp. 1270-1275 ◽

Cited By ~ 16

Author(s):

M. Hawa ◽

R. Rowe ◽

M. S. Lan ◽

A. L. Notkins ◽

P. Pozzilli ◽

...

Keyword(s):

Type 1 Diabetes ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine

Download Full-text

Genotypes of cytosolic low[ndash ]molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner

Metabolism ◽

10.1053/meta.2002.31317 ◽

2002 ◽

Vol 51 (4) ◽

pp. 419-422 ◽

Cited By ~ 19

Author(s):

N. Bottini ◽

G.F. Meloni ◽

P. Borgiani ◽

A. Giorgini ◽

R. Buzzetti ◽

...

Keyword(s):

Molecular Weight ◽

Type 1 Diabetes ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Age At Onset ◽

Molecular Weight Protein ◽

Protein Tyrosine ◽

Specific Manner ◽

Weight Protein

Download Full-text

Role of the C1858T polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in children and adolescents with type 1 diabetes

The Pharmacogenomics Journal ◽

10.1038/tpj.2016.6 ◽

2016 ◽

Vol 17 (2) ◽

pp. 186-191 ◽

Cited By ~ 8

Author(s):

A Blasetti ◽

C Di Giulio ◽

S Tumini ◽

M Provenzano ◽

D Rapino ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Receptor Type ◽

Protein Tyrosine

Download Full-text

Molecular Cloning and Characterization of the Human Transmembrane Protein Tyrosine Phosphatase Homologue, Phogrin, an Autoantigen of Type 1 Diabetes

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1996.1526 ◽

1996 ◽

Vol 227 (2) ◽

pp. 440-447 ◽

Cited By ~ 27

Author(s):

Eiji Kawasaki ◽

John C. Hutton ◽

George S. Eisenbarth

Keyword(s):

Type 1 Diabetes ◽

Molecular Cloning ◽

Protein Tyrosine Phosphatase ◽

Transmembrane Protein ◽

Tyrosine Phosphatase ◽

Protein Tyrosine

Download Full-text