EFFECT OF PRIOR NECK RADIATION THERAPY ON CLINICAL FEATURES OF PRIMARY HYPERPARATHYROIDISM AND ASSOCIATED THYROID TUMORS

2003 ◽  
Vol 9 (5) ◽  
pp. 353-362 ◽  
Author(s):  
Behzad Kalaghchi, MD ◽  
Stephen A. Brietzke, MD, FACP, FACE ◽  
Almond J. Drake III, MD, FACP, FACE ◽  
K. M. Mohamed Shakir, MD, FACP, FRCP, FACE
Keyword(s):  
Radiation Therapy ◽  
Primary Hyperparathyroidism ◽  
Clinical Features ◽  
Thyroid Tumors

scholarly journals Frequency of various types of neoplasia in a group of acromegalic patients

2013 ◽  
Vol 57 (8) ◽  
pp. 612-616
Author(s):  
Fernanda Bolfi ◽  
Helio Amante Miot ◽  
Mariangela Resende ◽  
Glaucia M. S. F. Mazeto ◽  
Fernando Gomes Romeiro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Basal Cell Carcinoma ◽  
Primary Hyperparathyroidism ◽  
High Frequency ◽  
Acanthosis Nigricans ◽  
Thyroid Nodules ◽  
Colon Adenocarcinoma ◽  
Thyroid Tumor ◽  
Thyroid Tumors

OBJECTIVE: To determine the frequency of colon cancer, primary hyperparathyroidism, thyroid tumor, and skin cancer in all acromegalic patients in follow-up at the Clinics Hospital - Botucatu Medical School, from 2005 to 2011. SUBJECTS AND METHODS: These patients were evaluated retrospectively for colon cancer, primary hyperparathyroidism, dermatological, and thyroid tumors. RESULTS: Of 29 patients included at the beginning of the study, two were excluded. Among 19 patients submitted to colonoscopy, one presented colon adenocarcinoma (5%). Thyroid nodules were present in 63% of patients, and papilliferous carcinoma was confirmed in two patients (7,7%). Four patients were confirmed as having primary hyperparathyroidism (15%). The most common dermatologic lesions were thickened skin (100%), acrochordons (64%), epidermal cysts (50%), and pseudo-acanthosis nigricans (50%). Only one patient presented basal cell carcinoma. CONCLUSION: Although a small number of acromegalic patients was studied, our findings confirm the high frequency of thyroid neoplasias and primary hyperparathyroidism in this group of patients.

scholarly journals Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre’s experience

2018 ◽  
Vol 7 (10) ◽  
pp. 1105-1115 ◽  
Author(s):  
Laura J Reid ◽  
Bala Muthukrishnan ◽  
Dilip Patel ◽  
Mike S Crane ◽  
Murat Akyol ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Features ◽  
Surgical Outcomes ◽  
Imaging Modality ◽  
Evidence Base ◽  
University Hospital ◽  
Clearance Ratio ◽  
Curative Surgery ◽  
History Of ◽  
Surgical Failure

Objective Primary hyperparathyroidism (PHPT) is a common reason for referral to endocrinology but the evidence base guiding assessment is limited. We evaluated the clinical presentation, assessment and subsequent management in PHPT. Design Retrospective cohort study. Patients PHPT assessed between 2006 and 2014 (n = 611) in a university hospital. Measurements Symptoms, clinical features, biochemistry, neck radiology and surgical outcomes. Results Fatigue (23.8%), polyuria (15.6%) and polydipsia (14.9%) were associated with PHPT biochemistry. Bone fracture was present in 16.4% but was not associated with biochemistry. A history of nephrolithiasis (10.0%) was associated only with younger age (P = 0.006) and male gender (P = 0.037). Thiazide diuretic discontinuation was not associated with any subsequent change in calcium (P = 0.514). Urine calcium creatinine clearance ratio (CCCR) was <0.01 in 18.2% of patients with confirmed PHPT. Older age (P < 0.001) and lower PTH (P = 0.043) were associated with failure to locate an adenoma on ultrasound (44.0% of scans). When an adenoma was identified on ultrasound the lateralisation was correct in 94.5%. Non-curative surgery occurred in 8.2% and was greater in those requiring more than one neck imaging modality (OR 2.42, P = 0.035). Conclusions Clinical features associated with PHPT are not strongly related to biochemistry. Thiazide cessation does not appear to attenuate hypercalcaemia. PHPT remains the likeliest diagnosis in the presence of low CCCR. Ultrasound is highly discriminant when an adenoma is identified but surgical failure is more likely when more than one imaging modality is required.

Clinical features and management of primary hyperparathyroidism discovered by parathyroid incidentaloma

2020 ◽  
Author(s):  
Jaksic Vlatka Pandzic ◽  
Ana Majic ◽  
Jelena Andric ◽  
Berkovic Maja Cigrovski ◽  
Srecko Marusic
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Features

scholarly journals Pituitary metastases: current practice in Japan

2015 ◽  
Vol 123 (4) ◽  
pp. 998-1007 ◽  
Author(s):  
Mika Habu ◽  
Hiroshi Tokimura ◽  
Hirofumi Hirano ◽  
Soichiro Yasuda ◽  
Yasushi Nagatomo ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Survival Time ◽  
Clinical Features ◽  
Median Survival ◽  
Median Survival Time ◽  
Cell Cancer ◽  
Optic Tract ◽  
Mass Lesion ◽  
Contributing Factors ◽  
Pituitary Metastases

OBJECT With advancement of cancer treatment and development of neuroimaging techniques, contemporary clinical pictures of pituitary metastases (PMs) must have changed from past reports. The goal of this paper was to elucidate the clinical features of PMs and current clinical practice related to those lesions. In this retrospective study, questionnaires were sent to 87 physicians who had treated PMs in Japan. RESULTS Between 1995 and 2010, 201 patients with PMs were treated by the participating physicians. The diagnosis of PM was histologically verified in 69 patients (34.3%). In the other 132 patients (65.7%), the PM was diagnosed by their physicians based on neuroimaging findings and clinical courses. The most frequent primary tumor was lung (36.8%), followed by breast (22.9%) and kidney (7.0%) cancer. The average interval between diagnosis of primary cancer and detection of PM was 2.8 ± 3.9 (SD) years. Major symptoms at diagnosis were visual disturbance in 30.3%, diabetes insipidus in 27.4%, fatigue in 25.4%, headache in 20.4%, and double vision in 17.4%. Major neuroimaging features were mass lesion in the pituitary stalk (63.3%), constriction of tumor at the diaphragmatic hiatus (44.7%), hypothalamic mass lesion (17.4%), and hyperintensity in the optic tract (11.4%). Surgical treatment was performed in 26.9% of patients, and 74.6% had radiation therapy; 80.0% of patients who underwent radiotherapy had stereotactic radiotherapy. The median survival time was 12.9 months in total. Contributing factors for good prognosis calculated by Cox proportional hazard analysis were younger age, late metastasis to the pituitary gland, smaller PM size, and radiation therapy. The Kaplan-Meier survival was significantly better in patients with breast cancer and renal cell cancer than in those with lung cancer. CONCLUSIONS At the time of this writing, approximately 60% (120/201) of PMs had been treated by stereotactic radiation therapy in Japan. The median survival time was much longer than that reported in past series. To confirm the changes of clinical features and medical practice, a prospective and population-based survey is mandatory.

scholarly journals Familial isolated hyperparathyroidism due to multiple adenomas associated with ossifying jaw fibroma and multiple uterine adenomyomatous polyps

1998 ◽  
pp. 557-561 ◽  
Author(s):  
M Fujikawa ◽  
K Okamura ◽  
K Sato ◽  
T Mizokami ◽  
K Tamaki ◽  
...  
Keyword(s):  
Young Adult ◽  
Primary Hyperparathyroidism ◽  
Clinical Features ◽  
Multiple Endocrine Neoplasia ◽  
Adult Onset ◽  
Female Patients ◽  
Endocrine Neoplasia ◽  
Parathyroid Adenomas ◽  
Uterine Polyps ◽  
Familial Hyperparathyroidism

We describe three siblings with hyperparathyroidism due to multiple parathyroid adenomas without evidence of other endocrinological abnormalities. A 22-year-old woman had two parathyroid adenomas complicated by multiple ossifying jaw fibromas. Her sister, aged 29, also suffered from primary hyperparathyroidism associated with two parathyroid adenomas one of which was also suspected to be a carcinoma. These two female patients had unusual multiple small uterine polyps, which were diagnosed as adenomyomatous polyps. Their brother, aged 17, had two parathyroid adenomas complicated by urolithiasis. These three patients are characterized by young adult-onset familial isolated hyperparathyroidism due to multiple adenomas with various complications including ossifying jaw fibroma and uterine adenomyomatous polyps. These clinical features are different from those of familial hyperparathyroidism associated with multiple endocrine neoplasia.

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