DISCREPANT AREAL AND VOLUMETRIC BONE DENSITY MEASUREMENTS IN A YOUNG WOMAN WITH IDIOPATHIC LOW BONE MINERAL DENSITY

2003 ◽  
Vol 9 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Debra H. Schussheim, MD ◽  
Mishaela R. Rubin, MD ◽  
Elizabeth Shane, MD
1996 ◽  
Vol 89 (8) ◽  
pp. 457-461 ◽  
Author(s):  
D J Torgerson ◽  
C Donaldson ◽  
D M Reid

Bone mineral density measurements have been criticized on the grounds that they are not a worth-while screening tool. In this paper we argue that bone mineral measurements can be an efficient diagnostic tool even if they are not of proven value for screening. There is complex relationship between the costs of a measurement, the intervention and the predictive value of the test all of which must be accounted for when assessing the value of a bone density measurement. For bone density measurements to be used for screening, a wider evaluation needs to be undertaken compared with that for their use as a diagnostic tool. We address some common objections, for example, that low compliance with screening would undermine efficiency, and show that these are not relevant. Evaluations of screening need to address issues that are likely to affect efficiency.


2017 ◽  
Vol 158 (32) ◽  
pp. 1252-1258 ◽  
Author(s):  
Szilvia Szamosi ◽  
Ágnes Horváth ◽  
Zoltán Szekanecz ◽  
Gabriella Szűcs

Abstract: In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is prevalent in several autoimmune diseases, including systemic sclerosis. Hypovitaminosis has been found to be associated with low bone mineral density and higher prevalence of osteoporosis in this group of patients. Determinants of low bone density in SSc are poorly understood. Studies have shown the importance of both traditional osteoporotic as well as disease-specific factors (extent of skin involvement, presence of internal organ manifestation, malabsorption, systemic sclerosis subtype, serological profile, medication) in the development of low bone mineral density. The relationship between low bone density in systemic sclerosis patients and the above mentioned risk factors may be more complex and the real role of each factor is unclear. Yet very few studies reported clinically relevant low bone mass outcomes such as fracture risk assessment and fracture associated mortality in scleroderma. This review aims to synthesize data about the essential role of vitamin D in immune homeostasis as well as the prevalence of hypovitaminosis, low bone density, changes in bone turnover markers and presence of osteoporosis in scleroderma patients. Orv Hetil. 2017; 158(32): 1252–1258.


2006 ◽  
Vol 35 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Terry J. Aspray ◽  
Pamela Stevenson ◽  
Sharon E. Abdy ◽  
David J. Rawlings ◽  
Tom Holland ◽  
...  

Bone ◽  
2000 ◽  
Vol 26 (4) ◽  
pp. 387-391 ◽  
Author(s):  
J.A. Kanis ◽  
O. Johnell ◽  
A. Oden ◽  
B. Jonsson ◽  
C. De Laet ◽  
...  

2003 ◽  
Vol 40 (3) ◽  
pp. 152-158 ◽  
Author(s):  
Fátima Aparecida Ferreira Figueiredo ◽  
Cynthia Brandão ◽  
Renata de Mello Perez ◽  
Walnei Fernandes Barbosa ◽  
Mario Kondo

BACKGROUND: Metabolic bone disease has long been associated with cholestatic disorders. However, data in noncholestatic cirrhosis are relatively scant. AIMS: To determine prevalence and severity of low bone mineral density in noncholestatic cirrhosis and to investigate whether age, gender, etiology, severity of underlying liver disease, and/or laboratory tests are predictive of the diagnosis. PATIENTS/METHODS: Between March and September/1998, 89 patients with noncholestatic cirrhosis and 20 healthy controls were enrolled in a cross-sectional study. All subjects underwent standard laboratory tests and bone densitometry at lumbar spine and femoral neck by dual X-ray absorptiometry. RESULTS: Bone mass was significantly reduced at both sites in patients compared to controls. The prevalence of low bone mineral density in noncholestatic cirrhosis, defined by the World Health Organization criteria, was 78% at lumbar spine and 71% at femoral neck. Bone density significantly decreased with age at both sites, especially in patients older than 50 years. Bone density was significantly lower in post-menopausal women patients compared to pre-menopausal and men at both sites. There was no significant difference in bone mineral density among noncholestatic etiologies. Lumbar spine bone density significantly decreased with the progression of liver dysfunction. No biochemical variable was significantly associated with low bone mineral density. CONCLUSIONS: Low bone mineral density is highly prevalent in patients with noncholestatic cirrhosis. Older patients, post-menopausal women and patients with severe hepatic dysfunction experienced more advanced bone disease. The laboratory tests routinely determined in patients with liver disease did not reliably predict low bone mineral density.


2013 ◽  
Author(s):  
Sonia Munoz Gil ◽  
Tomas Mut Dolera ◽  
Belen C Garrido Lopez ◽  
M D Torregrosa Maicas ◽  
R Girones Sarrio ◽  
...  

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