EFFECT OF THYROID HORMONE REPLACEMENT ON METHIONINE-STIMULATED HOMOCYSTEINE LEVELS IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

2006 ◽  
Vol 12 (5) ◽  
pp. 529-534 ◽  
Author(s):  
Shon Meek ◽  
Robert C. Smallridge
Keyword(s):  
Thyroid Hormone ◽  
Subclinical Hypothyroidism ◽  
Hormone Replacement ◽  
Controlled Study ◽  
Double Blind ◽  
Thyroid Hormone Replacement ◽  
Double Blind Placebo

scholarly journals The Effect of Thyroid Hormone Replacement on the Level of Blood Pressure in the Cases of Subclinical Hypothyroidism

2018 ◽  
Vol 8 (1) ◽  
pp. 24-28
Author(s):  
Sukriti Kumar ◽  
Sumit Rungta ◽  
Manish Gutch ◽  
Annesh Bhattacharya ◽  
Syed Mohd Razi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thyroid Hormone ◽  
Subclinical Hypothyroidism ◽  
Hormone Replacement ◽  
Thyroid Hormone Replacement

scholarly journals Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

2018 ◽  
Vol 103 (8) ◽  
pp. 2988-2997 ◽  
Author(s):  
Manuel R Blum ◽  
Baris Gencer ◽  
Luise Adam ◽  
Martin Feller ◽  
Tinh-Hai Collet ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Subclinical Hypothyroidism ◽  
Carotid Plaque ◽  
Carotid Atherosclerosis ◽  
Controlled Trial ◽  
Hormone Replacement ◽  
Intima Media Thickness ◽  
Thyroid Stimulating Hormone ◽  
Double Blind ◽  
The Impact

Abstract Context Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist. Objective To assess the impact of treatment of SHypo with levothyroxine on carotid atherosclerosis. Design and Setting Randomized, double-blind, placebo-controlled trial nested within the Thyroid Hormone Replacement for Subclinical Hypothyroidism trial. Participants Participants aged ≥65 years with SHypo [thyroid-stimulating hormone (TSH), 4.60 to 19.99 mIU/L; free thyroxine level within reference range]. Intervention Levothyroxine dose-titrated to achieve TSH normalization or placebo, including mock titrations. Main Outcome Measures Carotid intima media thickness (CIMT), maximum plaque thickness measured with ultrasound. Results One hundred eighty-five participants (mean age 74.1 years, 47% women, 96 randomized to levothyroxine) underwent carotid ultrasound. Overall mean TSH ± SD was 6.35 ± 1.95 mIU/L at baseline and decreased to 3.55 ± 2.14 mIU/L with levothyroxine compared with 5.29 ± 2.21 mIU/L with placebo (P < 0.001). After a median treatment of 18.4 months (interquartile range 12.2 to 30.0 months), mean CIMT was 0.85 ± 0.14 mm under levothyroxine and 0.82 ± 0.13 mm under placebo [between-group difference = 0.02 mm; 95% CI, −0.01 to 0.06; P = 0.30]. The proportion of carotid plaque was similar (n = 135; 70.8% under levothyroxine and 75.3% under placebo; P = 0.46). Maximum carotid plaque thickness was 2.38 ± 0.92 mm under levothyroxine and 2.37 ± 0.91 mm under placebo (between-group difference −0.03; 95% CI, −0.34 to 0.29; P = 0.86). There were no significant interactions between levothyroxine treatment and mean CIMT, according to sex, baseline TSH (categories 4.6 to 6.9, 7.0 to 9.9, and ≥10 mIU/L), or established cardiovascular disease (all P for interaction ≥ 0.14). Conclusion Normalization of TSH with levothyroxine was associated with no difference in CIMT and carotid atherosclerosis in older persons with SHypo.

scholarly journals The Evaluation of Diastolic Dysfunction with Tissue Doppler Echocardiography in Women with Subclinical Hypothyroidism and the Effect of L-Thyroxine Treatment on Diastolic Dysfunction: A Pilot Study

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Gulbanu Erkan ◽  
Aycan Fahri Erkan ◽  
Mustafa Cemri ◽  
Selma Karaahmetoglu ◽  
Mustafa Cesur ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Thyroid Hormone ◽  
Diastolic Dysfunction ◽  
Doppler Echocardiography ◽  
Subclinical Hypothyroidism ◽  
Hormone Replacement ◽  
Tissue Doppler ◽  
Thyroid Hormone Replacement ◽  
Thyroid Hormone Replacement Therapy ◽  
Sh Group

Background. Subclinical hypothyroidism (SH) predominantly affects women. The necessity of treatment in SH is controversial.Objective. We aimed to investigate the response of diastolic dysfunction to thyroid hormone replacement therapy (THRT) in women.Methods and Results. Twenty-two female subjects with SH and 20 euthyroid female controls were enrolled. Baseline and follow-up biochemical, hormonal, and echocardiographic evaluations were performed. Repeat echocardiograms were performed three months after the achievement of a euthyroid status with THRT. Mean baseline myocardial performance index (MPI) was0.27±0.08in the SH group, and0.22±0.06in the control group (P=0.03). MPI did not change significantly after THRT. Pulsed-wave Doppler findings were not different among the groups. However, tissue Doppler-derived mitral annular E’ velocities were significantly lower in the SH group. A moderate but significant improvement was observed in E’ velocities after THRT (13.2±3.87versus14.53±2.75,P=0.04). We also observed left ventricular concentric remodeling in SH patients which was reversible with THRT.Conclusions. Tissue Doppler echocardiography may be a useful tool for monitoring the response of diastolic dysfunction to thyroid hormone replacement therapy in patients with SH. Our findings suggest that THRT may reverse diastolic dysfunction in women with SH.

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