LIFE-THREATENING HYPONATREMIA DUE TO THE SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE (SIADH) IN A PATIENT WITH THE MILLER FISHER SYNDROME

1995 ◽  
Vol 1 (3) ◽  
pp. 163-165 ◽  
Author(s):  
Sunil T. Ramaprasad ◽  
Leonid Poretsky
Keyword(s):  
Antidiuretic Hormone ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
Inappropriate Secretion ◽  
Life Threatening

scholarly journals A Case of Miller-Fisher Syndrome with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

2021 ◽  
pp. 380-383
Author(s):  
Shunya Fujiwara ◽  
Yasuhiro Manabe ◽  
Yumiko Nakano ◽  
Yoshio Omote ◽  
Hisashi Narai ◽  
...  
Keyword(s):  
Antidiuretic Hormone ◽  
Immunoglobulin Therapy ◽  
Sodium Concentration ◽  
Miller Fisher Syndrome ◽  
Intravenous Immunoglobulin Therapy ◽  
Fisher Syndrome ◽  
Upper Respiratory Infection ◽  
Inappropriate Secretion ◽  
Unsteady Gait ◽  
Upper Respiratory

We report a 72-year-old woman with Miller-Fisher syndrome (MFS) with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). She developed diplopia and unsteady gait a week after an upper respiratory infection. Neurologic examination revealed ophthalmoplegia, ataxia, symmetrical weakness, numbness, and areflexia. She underwent intravenous immunoglobulin therapy. Her serum sodium concentration decreased to 119 mEq/L on day 12. She had low plasma osmolarity (254 mosm/kg), high urine osmolarity (457 mosm/kg), and high urine sodium level (73 mEq/L), while the blood level of antidiuretic hormone was normal. Anti-GD1b immunoglobulin G (IgG), -GQ1b IgG, -GT1a IgG, and -Gal-C IgM antibodies were positive. We diagnosed her with MFS overlapping with SIADH. Four weeks after onset, her symptoms recovered. The elevation of anti-GD1b, -GQ1b, and -GT1a antibodies that recognize disialosyl residue may be pathologically related to SIADH.

scholarly journals Life threatening hyponatraemia following evacuation of spontaneous chronic subdural haematoma

2014 ◽  
Vol 96 (6) ◽  
pp. e26-e27
Author(s):  
R Johnson ◽  
T Ibrahim
Keyword(s):  
Antidiuretic Hormone ◽  
Subdural Haematoma ◽  
Chronic Subdural Haematoma ◽  
Burr Hole ◽  
Pituitary Stalk ◽  
Brain Shift ◽  
First Report ◽  
Inappropriate Secretion ◽  
Life Threatening

We report the case of a 43-year-old woman who developed life threatening hyponatraemia 4 days following burr hole drainage of a spontaneous chronic subdural haematoma (CSDH). Syndrome of inappropriate secretion of antidiuretic hormone was confirmed. This is the first report of delayed life threatening hyponatraemia developing postoperatively in CSDH. The mechanism remains unclear but may involve brain shift on the pituitary stalk following subdural evacuation.

Early inappropriate secretion of antidiuretic hormone after trans-sphenoidal pituitary adenomectomy

1990 ◽  
Vol 104 (11) ◽  
pp. 894-895 ◽  
Author(s):  
G. E. Murty ◽  
P. Lamballe ◽  
A. R. Welch
Keyword(s):  
Antidiuretic Hormone ◽  
Clinical Features ◽  
Early Presentation ◽  
Inappropriate Secretion ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
Late Phenomenon

AbstractThe syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a rare but life-threatening complication of trans-sphenoidal pituitary adenomectomy. It has previously only been described as a late phenomenon. We report an early presentation within the first week. The pathophysiology, clinical features and treatment are discussed.

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