Pharmaceutical aerosol electrostatics: a field with much potential for development

2015 ◽  
Vol 6 (2) ◽  
pp. 105-107 ◽  
Author(s):  
Philip Chi Lip Kwok
Keyword(s):  
Pharmaceutical Aerosol

A Rapid Method for the determination of Dehydrated alcohol (Ethanol) content in Clobetasol propionate foam by Non-polar Capillary Gas chromatography

2021 ◽  
pp. 5919-5925
Author(s):  
K.S.M.L. Sushmitha ◽  
Kumarswamy Ummiti ◽  
J.V. Shanmukha Kumar
Keyword(s):  
Gas Chromatography ◽  
Drug Product ◽  
Skin Permeation ◽  
Internal Standard ◽  
Fused Silica ◽  
Clobetasol Propionate ◽  
Chromatography Method ◽  
Droplet Shape ◽  
Ethanol Content ◽  
Pharmaceutical Aerosol

Clobeatsol propionate foam is a topical class 1 corticosteroid used to treat itching and inflammatory arthritis on the skin occurred by allergic reactions, psoriasis and eczema. In the pharmaceutical aerosol products, Dehydrated alcohol (Ethanol) is the primary ingredient and its concentration level in the formulation composition plays a significant role in the regulation of aerosol rate, droplet shape and particle size. It can also act as solubilizer for active pharmaceutical ingredient, topical disinfectant and skin permeation enhancer. Hence accurate assay of Ethanol is a crucial quality control component. A simple and rapid gas chromatography method was developed to quantify Ethanol content in Clobetasol propionate foam drug product using fused silica glass tube non-polar capillary column (HP-5, 30 m, 0.53 mm, 1.5 µm). Ethanol in the sample was diluted with methanol after adding suitable amount of internal standard, the isopropyl alcohol solution.The developed method is precise, linear and accurate in the range of 5 mg/mL to 15 mg/mL of nominal concentration of ethanol i.e. 10 mg/mL . The presented method has an advantage of a very quick gas chromatographic separation (less than 16 min) and therefore is highly suitable for in-process and stability analysis of Ethanol content in Clobetasol propionate foam drug product.

scholarly journals Development of a High-Flow Nasal Cannula and Pharmaceutical Aerosol Combination Device

2019 ◽  
Vol 32 (4) ◽  
pp. 224-241 ◽  
Author(s):  
Benjamin M. Spence ◽  
Worth Longest ◽  
Xiangyin Wei ◽  
Sneha Dhapare ◽  
Michael Hindle
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
High Flow Nasal Cannula ◽  
Combination Device ◽  
Pharmaceutical Aerosol

A Concise Overview on Recent Advances in Pharmaceutical Aerosols and Their Commercial Applications

2021 ◽  
Vol 14 ◽  
Author(s):  
Raghav Mishra ◽  
Radhika Agarwal
Keyword(s):  
Pharmaceutical Products ◽  
Chronic Obstructive ◽  
Pharmaceutical Aerosols ◽  
Obstructive Pulmonary Disease ◽  
Therapy Termination ◽  
Rising Incidence ◽  
Commercial Applications ◽  
Pharmaceutical Aerosol ◽  
Localized Drug Delivery ◽  
Inhaler Devices

Background: Localized drug delivery to the respiratory system has become an increasingly successful and essential treatment strategy for several pulmonary diseases, including asthma, chronic abstractive disease, pneumonia, bronchitis, and cystic fibrosis. The rising incidence of respiratory diseases is a significant factor driving the worldwide market for respiratory inhaler devices. Objective: The objective of this article is to present various aspects of pharmaceutical aerosols, including their types, components, fundamentals, in-process and finished product quality control tests based on pharmacopeial standards and specifications, and commercial utility considering the pharmaceutical aerosol dosage forms that have been patented from 2000 to 2020, along with a list of marketed pharmaceutical products. Method: Aerosol, collectively referred to as a pressurized device, operates by triggering an appropriate valve system with a continuous or metered dosage of tiny mist spray. It is used not only in the treatment of asthma and chronic obstructive pulmonary disease but also in the treatment of cancer, diabetes, migraine, angina pectoris, acute lung injury, bone disorders, tuberculosis, and many more. A multitude of different variables, including types and properties of propellants, active substances, containers, valves, actuators, spray patterns, valve crimping efficiency, and particle size of the aerosols, influence the therapeutic effectiveness of pharmaceutical aerosols. Conclusion: Based on the current findings, distinct characteristics such as the elimination of firstpass metabolism, quick drug absorption, ease of therapy termination, as well as a larger surface area have attributed to the success of pharmaceutical aerosols.

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