Physical stabilization of low-molecular-weight amorphous drugs in the solid state: a material science approach

2014 ◽  
Vol 5 (7) ◽  
pp. 817-841 ◽  
Author(s):  
Sheng Qi ◽  
William J McAuley ◽  
Ziyi Yang ◽  
Pratchaya Tipduangta
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Material Science ◽  
Low Molecular Weight ◽  
Science Approach ◽  
Amorphous Drugs ◽  
Physical Stabilization

γ-Ray Irradiation Practical Conditions for Low Molecular Weight Chitosan Material Production

2003 ◽  
Vol 792 ◽  
Author(s):  
Rangrong Yoksan ◽  
Mitsuru Akashi ◽  
Mikiji Miyata ◽  
Siriratana Biramontri ◽  
Suwabun Chirachanchai
Keyword(s):  
Molecular Weight ◽  
Acetic Acid ◽  
Solid State ◽  
Primary Structure ◽  
Low Molecular Weight ◽  
Aqueous Acetic Acid ◽  
Low Molecular Weight Chitosan ◽  
Backbone Structure ◽  
Γ Ray ◽  
Terminal Chain

ABSTRACTThe present work focuses on the γ-ray irradiation doses and conditions (dry solid state, solid state dispersing in 0.5–2 % aqueous H2O2 solution, solid state dispersing in 1% aqueous acetic acid, and 2% aqueous K2S2O8) to determine the level that the molecular weight of chitosan is lowered significantly without changing its primary structure. Molecular weight of chitosan (105-106 Dalton) is reduced approximately 50% under the γ-ray dose of 20 kGy in the dry solid state. The decrease in molecular weight is enhanced up to 80% when chitosan is suspended in 0.5–2 % aqueous H2O2 solution during γ-ray irradiation. In either condition, the backbone structure of the irradiated product is maintained with little change in the terminal chain. In the cases of (i) chitosan suspended in 2% aqueous K2S2O8 and (ii) chitosan in 1% aqueous acetic acid, chitosans lose their primary structures and physical properties.

scholarly journals An all solid-state Li ion battery composed of low molecular weight crystalline electrolyte

RSC Advances ◽  
2020 ◽  
Vol 10 (15) ◽  
pp. 8780-8789 ◽  
Author(s):  
Prerna Joshi ◽  
Raman Vedarajan ◽  
Anjaiah Sheelam ◽  
Kothandaraman Ramanujam ◽  
Bernard Malaman ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Lewis Acid ◽  
Low Molecular Weight ◽  
Li Ion Battery ◽  
Acid Base ◽  
Base Interaction ◽  
Li Ion ◽  
Acid Base Interaction

A non-polymer crystalline organoboron electrolyte results in the formation of nano-channels for directional conduction of Li ions, owing to presence of boron, allowing Lewis acid–base interaction.

A stable and efficient quasi-solid-state dye-sensitized solar cell with a low molecular weight organic gelator

2012 ◽  
Vol 5 (3) ◽  
pp. 6151 ◽  
Author(s):  
Qingjiang Yu ◽  
Cuiling Yu ◽  
Fengyun Guo ◽  
Jinzhong Wang ◽  
Shujie Jiao ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Solar Cell ◽  
Solid State ◽  
Dye Sensitized Solar Cell ◽  
Low Molecular Weight ◽  
Dye Sensitized

Three dimensional heteroatom-doped carbon composite film for flexible solid-state supercapacitors

RSC Advances ◽  
2016 ◽  
Vol 6 (6) ◽  
pp. 4483-4489 ◽  
Author(s):  
Ben-Xue Zou ◽  
You Gao ◽  
Bo Liu ◽  
Yongpeng Yu ◽  
Yanhua Lu
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Composite Film ◽  
Active Carbon ◽  
Resin Composite ◽  
Three Dimensional ◽  
Carbon Composite ◽  
Low Molecular Weight ◽  
Supercapacitor Electrode ◽  
Flexible Supercapacitor

Three dimensional (3D) heteroatom-doped active carbon as a flexible supercapacitor electrode is explored with a starting material of silkworm fibers and low molecular weight phenol resin composite.

ChemInform Abstract: Fabrication of Quasi-Solid-State Dye-Sensitized TiO2 Solar Cells Using Low Molecular Weight Gelators.

ChemInform ◽  
2010 ◽  
Vol 30 (19) ◽  
pp. no-no
Author(s):  
Wataru Kubo ◽  
Kei Murakoshi ◽  
Takayuki Kitamura ◽  
Yuji Wada ◽  
Kenji Hanabusa ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Solar Cells ◽  
Solid State ◽  
Low Molecular Weight ◽  
Dye Sensitized ◽  
Low Molecular Weight Gelators

scholarly journals Melting of Low Molecular Weight Compounds in Confinement Observed by2H-Solid State NMR: Biphenyl, a Case Study

2012 ◽  
Vol 226 (11-12) ◽  
pp. 1169-1186 ◽  
Author(s):  
Nader de Sousa Amadeu ◽  
Bob Grünberg ◽  
Jarek Frydel ◽  
Mayke Werner ◽  
Hans-Heinrich Limbach ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Solid State Nmr ◽  
Low Molecular Weight ◽  
Low Molecular Weight Compounds

Fabrication of Quasi-solid-state Dye-sensitized TiO2Solar Cells Using Low Molecular Weight Gelators

1998 ◽  
Vol 27 (12) ◽  
pp. 1241-1242 ◽  
Author(s):  
Wataru Kubo ◽  
Kei Murakoshi ◽  
Takayuki Kitamura ◽  
Yuji Wada ◽  
Kenji Hanabusa ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Low Molecular Weight ◽  
Dye Sensitized ◽  
Low Molecular Weight Gelators

scholarly journals Purification and characterization of a low molecular weight xylanase from solid-state cultures of Aspergillus fumigatus Fresenius

1999 ◽  
Vol 30 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Claudio Henrique Cerri e Silva ◽  
Jurgen Puls ◽  
Marcelo Valle de Sousa ◽  
Edivaldo Ximenes Ferreira Filho
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Aspergillus Fumigatus ◽  
Gel Filtration ◽  
Low Molecular Weight ◽  
Transferase Activity ◽  
Purification And Characterization ◽  
Apparent Homogeneity ◽  
Sds Page

A xylan-degrading enzyme (xylanase II) was purified to apparent homogeneity from solid-state cultures of Aspergillus fumigatus Fresenius. The molecular weight of xylanase II was found to be 19 and 8.5 kDa, as estimated by SDS-PAGE and gel filtration on FPLC, respectively. The purified enzyme was most active at 55 °C and pH 5.5. It was specific to xylan. The apparent Km and Vmax values on soluble and insoluble xylans from oat spelt and birchwood showed that xylanase II was most active on soluble birchwood xylan. Studies on hydrolysis products of various xylans and xylooligomers by xylanase II on HPLC showed that the enzyme released a range of products from xylobiose to xylohexaose, with a small amount of xylose from xylooligomers, and presented transferase activity.

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