pH-sensitive drug-delivery systems for tumor targeting

2013 ◽  
Vol 4 (12) ◽  
pp. 1499-1510 ◽  
Author(s):  
Xi He ◽  
Jianfeng Li ◽  
Sai An ◽  
Chen Jiang
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Sensitive

“Smart” Nanocarriers: A New Paradigm for Tumor Targeting Drug Delivery Systems

2011 ◽  
Vol 1 (1) ◽  
pp. 67-84
Author(s):  
Zhigang Hu ◽  
Fei Huo ◽  
Yi Zhang ◽  
Chunyang Chen ◽  
Kehua Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Paradigm

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

“Smart” Nanocarriers: A New Paradigm for Tumor Targeting Drug Delivery Systems

2011 ◽  
Vol 1 (1) ◽  
pp. 67-84
Author(s):  
Zhigang Hu ◽  
Fei Huo ◽  
Yi Zhang ◽  
Chunyang Chen ◽  
Kehua Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Paradigm

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting

2021 ◽  
Vol 22 ◽  
Author(s):  
Rui Wang ◽  
Xianyi Sha
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Biological Function ◽  
Delivery Systems ◽  
Biological Functions ◽  
Simple Preparation ◽  
Targeting Delivery ◽  
Clinical Transformation ◽  
Endogenous Substances

: The emergence of nanoscale drug delivery systems provides new opportunities for targeting delivery of chemotherapeutic drugs and has achieved excellent results. In recent years, with the arising of the concept of intelligent drug delivery systems, the design and preparation of carriers have become more and more complicated, which is not conducive to clinical transformation. Researchers are gradually focusing on biomimetic nanoscale drug delivery systems, trying to combine the physicochemical properties of nanoscale carriers with the natural biological functions of endogenous substances, so as to boost tumor targeting delivery. In this article, we first classify and introduce biomimetic nanoscale drug delivery systems, and then emphasize their unique biological functions. The biomimetic nanoscale drug delivery systems have the advantages of simple preparation, powerful functions, and low immunogenicity, having a good application prospect.

Sign in / Sign up

Export Citation Format

Share Document