Triple monoamine uptake inhibitors

2012 ◽  
Vol 1 (4) ◽  
pp. 469-481 ◽  
Author(s):  
Anna Maria Capelli ◽  
Fabrizio Micheli
Keyword(s):  
Monoamine Uptake ◽  
Uptake Inhibitors ◽  
Monoamine Uptake Inhibitors

Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice

2019 ◽  
Vol 30 (6) ◽  
pp. 463-470
Author(s):  
Khadijah S. Alexander ◽  
Taylor R. Rodriguez ◽  
Amma N. Sarfo ◽  
Tadd B. Patton ◽  
Laurence L. Miller
Keyword(s):  
Monoamine Uptake ◽  
Uptake Inhibitors ◽  
Monoamine Uptake Inhibitors

Monoamine uptake inhibitors block α7-nAChR-mediated cerebral nitrergic neurogenic vasodilation

2006 ◽  
Vol 291 (1) ◽  
pp. H202-H209 ◽  
Author(s):  
Cheng Long ◽  
Mei-Fang Chen ◽  
Susan J. Sarwinski ◽  
Po-Yi Chen ◽  
Minliang Si ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Sympathetic Neurons ◽  
Monoamine Uptake ◽  
Uptake Inhibitors ◽  
Α7 Nachr ◽  
Inward Currents ◽  
Monoamine Uptake Inhibitors ◽  
Α7 Nachrs ◽  
Neurogenic Vasodilation

We have proposed that activation of cerebral perivascular sympathetic α7-nicotinic acetylcholine receptors (α7-nAChRs) by nicotinic agonists releases norepinephrine, which then acts on parasympathetic nitrergic nerves, resulting in release of nitric oxide and vasodilation. Using patch-clamp electrophysiology, immunohistochemistry, and in vitro tissue bath myography, we tested this axo-axonal interaction hypothesis further by examining whether blocking norepinephrine reuptake enhanced α7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. The results indicated that choline- and nicotine-induced α7-nAChR-mediated nitrergic neurogenic relaxation in endothelium-denuded isolated porcine basilar artery rings was enhanced by desipramine and imipramine at lower concentrations (0.03–0.1 μM) but inhibited at higher concentrations (0.3–10 μM). In cultured superior cervical ganglion (SCG) neurons of the pig and rat, choline (0.1–30 mM)-evoked inward currents were reversibly blocked by 1–30 μM mecamylamine, 1–30 μM methyllycaconitine, 10–300 nM α-bungarotoxin, and 0.1–10 μM desipramine and imipramine, providing electrophysiological evidence for the presence of similar functional α7-nAChRs in cerebral perivascular sympathetic neurons of pigs and rats. In α7-nAChR-expressing Xenopus oocytes, choline-elicited inward currents were attenuated by α-bungarotoxin, imipramine, and desipramine. These monoamine uptake inhibitors appeared to directly block the α7-nAChR, resulting in diminished nicotinic agonist-induced cerebral nitrergic vasodilation. The enhanced nitrergic vasodilation by lower concentrations of monoamine uptake inhibitors is likely due to a greater effect on monoamine uptake than on α7-nAChR blockade. These results further support the hypothesis of axo-axonal interaction in nitrergic regulation of cerebral vascular tone.

Effect of monoamine uptake inhibitors on norepinephrine-stimulated phosphatidylinositol hydrolysis in rat cortex

1989 ◽  
Vol 38 (2) ◽  
pp. 257-262 ◽  
Author(s):  
Mahmood Mosaddeghi ◽  
Joseph M. Moerschbaecher ◽  
Rueben A. Gonzales
Keyword(s):  
Rat Cortex ◽  
Monoamine Uptake ◽  
Uptake Inhibitors ◽  
Monoamine Uptake Inhibitors

scholarly journals Triple monoamine uptake inhibitors demonstrate a pharmacologic association between excessive drinking and impulsivity in high-alcohol-preferring (HAP) mice

2013 ◽  
Vol 20 (2) ◽  
pp. 236-247 ◽  
Author(s):  
David S. O'Tousa ◽  
Kaitlin T. Warnock ◽  
Liana M. Matson ◽  
Ojas A. Namjoshi ◽  
Michael Van Linn ◽  
...  
Keyword(s):  
High Alcohol ◽  
Excessive Drinking ◽  
Monoamine Uptake ◽  
Uptake Inhibitors ◽  
Monoamine Uptake Inhibitors

In Vitro Effects of Cocaine, Lidoce and Monoamine Uptake Inhibitors On Lymphocyte Proliferative Responses

1994 ◽  
Vol 16 (2) ◽  
pp. 165-178 ◽  
Author(s):  
Michele B. Berkeley ◽  
Sandra Daussin ◽  
Monica C. Hernandez ◽  
Barbara M. Bayer
Keyword(s):  
Monoamine Uptake ◽  
Uptake Inhibitors ◽  
In Vitro Effects ◽  
Monoamine Uptake Inhibitors
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