Qualification of a differential scanning calorimetry method for biophysical characterization of monoclonal antibodies and protein vaccine antigens

2014 ◽  
Vol 2 (6) ◽  
pp. 491-498 ◽  
Author(s):  
Marina Kirkitadze ◽  
Jian Hu ◽  
Mei Tang ◽  
Bruce Carpick
Keyword(s):  
Differential Scanning Calorimetry ◽  
Monoclonal Antibodies ◽  
Protein Vaccine ◽  
Scanning Calorimetry ◽  
Biophysical Characterization ◽  
Differential Scanning Calorimetry Method ◽  
Vaccine Antigens

Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel

2020 ◽  
Vol 17 (4) ◽  
pp. 303-311
Author(s):  
Roberta Cassano ◽  
Federica Curcio ◽  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Sonia Trombino
Keyword(s):  
Differential Scanning Calorimetry ◽  
Inflammatory Process ◽  
Vaginal Mucosa ◽  
Vaginal Infection ◽  
Scanning Calorimetry ◽  
Time Intervals ◽  
Site Specific ◽  
Release Studies ◽  
Hiv Seropositive

Aim: The work’s aim was the preparation and characterization of a hydrogel based on gelatin and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate the inflammatory process typical of the vaginal infection. Objective: The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM) and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel exhibits a relevant mucoadhesive activity. Methods: The swelling degree was evaluated at two different pHs and at defined time intervals. In particular, phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate the physiological environment. Results: The obtained results revealed that the hydrogel swells up well at both pHs. Conclusion: Release studies conducted at both pathological and physiological pHs have shown that benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal mucosa.

scholarly journals Identification of LDPE Grades Focusing on Specific CH2 Raman Vibration Modes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Richard Jumeau ◽  
Patrice Bourson ◽  
Michel Ferriol ◽  
François Lahure ◽  
Marc Ponçot ◽  
...  
Keyword(s):  
Differential Scanning Calorimetry ◽  
Raman Spectroscopy ◽  
Vibrational Spectroscopy ◽  
Phenomenological Model ◽  
Low Density ◽  
Vibration Modes ◽  
Scanning Calorimetry ◽  
Lamella Thickness ◽  
Poly Ethylene

The possibilities of applications of vibrational spectroscopy techniques (Raman spectroscopy) in the analysis and characterization of polymers are more and more used and accurate. In this paper, our purpose is to characterize Low Density Poly(Ethylene) (LDPE) grades by Raman spectroscopy and in particular with CH2 Raman vibration modes. With temperature measurements, we determine different amorphous and crystalline Raman assignments. From these results and on the basis of the evolution of CH2 bending Raman vibration modes, we develop a phenomenological model in correlation with Differential Scanning Calorimetry and in particular with crystalline lamella thickness determination.

Effect of Electroplastic Deformation on Martensitic Transformation in Coarse Grained and Ultrafine Grained Ni-Ti Shape Memory Alloy

2008 ◽  
Vol 584-586 ◽  
pp. 127-132 ◽  
Author(s):  
Anastasia E. Sergeeva ◽  
Daria Setman ◽  
Michael Zehetbauer ◽  
Sergey Prokoshkin ◽  
Vladimir V. Stolyarov
Keyword(s):  
Differential Scanning Calorimetry ◽  
Martensitic Transformation ◽  
Shape Memory Alloy ◽  
Cold Rolling ◽  
Shape Memory ◽  
Coarse Grained ◽  
Scanning Calorimetry ◽  
Structure Relaxation ◽  
Differential Scanning Calorimetry Method ◽  
Ultrafine Grained

The aim of this paper is the investigation of electroplastic deformation (EPD) and subsequent annealing influence on martensitic transformation in the shape memory Ni50.7Ti49.3 alloy. Using differential scanning calorimetry method it was shown that EPD at the low strain stimulates structure relaxation and recovers martensitic transformation in cooling, which is usually suppressed by cold rolling.

scholarly journals STRUCTURAL AND MECHANICAL CHARACTERIZATION OF DEFORMED POLYMER USING CONFOCAL RAMAN MICROSCOPY AND DSC

2016 ◽  
Vol 3 ◽  
pp. 47-50
Author(s):  
Birgit Neitzel ◽  
Florian Aschermayer ◽  
Milan Kracalik ◽  
Sabine Hild
Keyword(s):  
Differential Scanning Calorimetry ◽  
Raman Spectroscopy ◽  
Mechanical Characterization ◽  
Polymer Chains ◽  
Polymer Materials ◽  
Confocal Raman Microscopy ◽  
Micro Structure ◽  
Scanning Calorimetry ◽  
Confocal Raman

Polymers have various interesting properties, which depend largely on their inner structure. One way to influence the macroscopic behaviour is the deformation of the polymer chains, which effects the change in microstructure. For analyzing the microstructure of non-deformed and deformed polymer materials, Raman spectroscopy as well as differential scanning calorimetry (DSC) were used. In the present study we compare the results for crystallinity measurements of deformed polymers using both methods in order to characterize the differences in micro-structure due to deformation. The study is ongoing, and we present the results of the first tests.

scholarly journals THERMAL CHARACTERIZATION OF THE FAVELONE DERIVATIVES (CNIDOSCOLUS QUERCIFOLIUS) BY THERMOGRAVIMETRY AND DIFFERENTIAL SCANNING CALORIMETRY

2006 ◽  
Vol 05 (3) ◽  
pp. 8-20
Author(s):  
José Carlos Oliveira SANTOS ◽  
Lionete Dantas NUNES ◽  
Sylvia Berenice NÓBREGA ◽  
Dantas José Pires PUZINSKI ◽  
Antonio Gouveia SOUZA
Keyword(s):  
Differential Scanning Calorimetry ◽  
Arid Region ◽  
Agricultural Practices ◽  
Thermal Characterization ◽  
Northeastern Brazil ◽  
Scanning Calorimetry ◽  
Semi Arid Region ◽  
Derivatives Of ◽  
Semi Arid

A thermal analysis has been applied to characterization of food and food products. Taking into account the problems of desertification and agricultural practices able to provide income to the population at the semi-arid region of Northeastern Brazil, this work presents the results of the chemical, thermal and kinetic characterization by thermogravimetry and differential scanning calorimetry of the seed derivatives of favelone (cnidoscolus quercifolius), aiming at the application of these materials as an alternative of food source for animals and for the human population at this brazilian region.

scholarly journals Synthesis, Mesomorphism and the Optical Properties of Alkyl-deuterated Nematogenic 4-[(2,6-difluorophenyl)ethynyl]biphenyls

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4653
Author(s):  
Jakub Herman ◽  
Piotr Harmata ◽  
Michał Czerwiński ◽  
Olga Strzeżysz ◽  
Marta Pytlarczyk ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Mass Spectrometry ◽  
Differential Scanning Calorimetry ◽  
Optical Properties ◽  
Liquid Crystalline ◽  
Near Infrared ◽  
Synthesis And Characterization ◽  
Molecular Approach ◽  
Scanning Calorimetry

The synthesis and characterization of new deuterated liquid crystal (LC) compounds based on phenyl tolane core is described in this paper. The work presents an alternative molecular approach to the conventional LC design. Correlations between molecular structure and mesomorphic and optical properties for compounds which are alkyl-hydrogen terminated and alkyl-deuterium, have been drawn. The compounds are characterized by mass spectrometry (electron ionization) analysis and infrared spectroscopy. They show enantiotropic nematic behavior in a broad temperature range, confirmed by a polarizing thermomicroscopy and differential scanning calorimetry. Detailed synthetic procedures are attached. Synthesized compounds show a significantly reduced absorption in the near-infrared (NIR) and medium-wavelength infrared (MWIR) radiation range, and stand as promising components of medium to highly birefringent liquid crystalline mixtures.

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