The use of glutamine synthetase as a selection marker: recent advances in Chinese hamster ovary cell line generation processes

Lianchun Fan; Christopher C Frye; Andrew J Racher

doi:10.4155/pbp.13.56

The use of glutamine synthetase as a selection marker: recent advances in Chinese hamster ovary cell line generation processes

Pharmaceutical Bioprocessing ◽

10.4155/pbp.13.56 ◽

2013 ◽

Vol 1 (5) ◽

pp. 487-502 ◽

Cited By ~ 17

Author(s):

Lianchun Fan ◽

Christopher C Frye ◽

Andrew J Racher

Keyword(s):

Glutamine Synthetase ◽

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Selection Marker ◽

Ovary Cell Line ◽

Cell Line Generation ◽

Line Generation

Download Full-text

Cell Xpress™ Technology Facilitates High-Producing Chinese Hamster Ovary Cell Line Generation Using Glutamine Synthetase Gene Expression System

Cells and Culture ◽

10.1007/978-90-481-3419-9_9 ◽

2010 ◽

pp. 45-48 ◽

Cited By ~ 1

Author(s):

Genova A. Richardson ◽

Nan Lin ◽

Kimberly A. Lacy ◽

Lynn A. Davis ◽

Misa I. Gray ◽

...

Keyword(s):

Gene Expression ◽

Glutamine Synthetase ◽

Chinese Hamster Ovary ◽

Expression System ◽

Chinese Hamster ◽

Ovary Cell ◽

Gene Expression System ◽

Ovary Cell Line ◽

Cell Line Generation ◽

Line Generation

Download Full-text

A recombinant Chinese hamster ovary cell line containing a 300-fold amplified tetramer of the hepatitis B genome together with a double selection marker expresses high levels of viral protein

Journal of Molecular Biology ◽

10.1016/0022-2836(86)90312-8 ◽

1986 ◽

Vol 189 (3) ◽

pp. 401-411 ◽

Cited By ~ 18

Author(s):

Fred A.M. Asselbergs ◽

Hans Will ◽

Paul Wingfield ◽

Marlis Hirschi

Keyword(s):

Hepatitis B ◽

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Viral Protein ◽

Chinese Hamster ◽

Ovary Cell ◽

Selection Marker ◽

B Genome ◽

Ovary Cell Line

Download Full-text

Role of protein synthesis in the repair of sublethal x-ray damage in a mutant Chinese hamster ovary cell line

10.2172/5749675 ◽

1985 ◽

Author(s):

M.J. Yezzi

Keyword(s):

Protein Synthesis ◽

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

X Ray ◽

Ovary Cell Line

Download Full-text

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

Mutation Research/DNA Repair Reports ◽

10.1016/0167-8817(83)90026-3 ◽

1983 ◽

Vol 112 (6) ◽

pp. 313-327 ◽

Cited By ~ 152

Author(s):

P.A. Jeggo ◽

L.M. Kemp

Keyword(s):

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Cross Sensitivity ◽

X Ray ◽

Dna Damaging Agents ◽

Ovary Cell Line

Download Full-text

Pharmacological characterization of a Chinese hamster ovary cell line transfected with the human CCK-B receptor gene

Neuropeptides ◽

10.1016/s0143-4179(96)90025-6 ◽

1996 ◽

Vol 30 (4) ◽

pp. 359-363 ◽

Cited By ~ 11

Author(s):

J Dunlop ◽

N Brammer ◽

C Ennis

Keyword(s):

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Receptor Gene ◽

Chinese Hamster ◽

Ovary Cell ◽

Pharmacological Characterization ◽

Ovary Cell Line

Download Full-text

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

British Journal of Pharmacology ◽

10.1038/sj.bjp.0702780 ◽

1999 ◽

Vol 128 (1) ◽

pp. 1-3 ◽

Cited By ~ 136

Author(s):

D Smart ◽

J C Jerman ◽

S J Brough ◽

S L Rushton ◽

P R Murdock ◽

...

Keyword(s):

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Receptor Pharmacology ◽

Ovary Cell Line

Download Full-text

Lipid Requirements of a Recombinant Chinese Hamster Ovary Cell Line (CHO)

New Developments and New Applications in Animal Cell Technology ◽

10.1007/0-306-46860-3_36 ◽

2006 ◽

pp. 205-207 ◽

Cited By ~ 1

Author(s):

Jeffrey T. Mcgrew ◽

Cheryl L. Richards ◽

Pauline Smidt ◽

Bradley Dell ◽

Virginia Price

Keyword(s):

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Ovary Cell Line

Download Full-text

Isolation and characterization of a Chinese hamster ovary cell line deficient in fatty alcohol:NAD+ oxidoreductase activity.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.87.16.6102 ◽

1990 ◽

Vol 87 (16) ◽

pp. 6102-6106 ◽

Cited By ~ 9

Author(s):

P. F. James ◽

W. B. Rizzo ◽

J. Lee ◽

R. A. Zoeller

Keyword(s):

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Oxidoreductase Activity ◽

Isolation And Characterization ◽

Ovary Cell Line

Download Full-text

Increased chromosomal radiosensitivity of a Chinese hamster ovary cell line that inducibly expresses the Eco RI restriction endonuclease

Biochemical and Biophysical Research Communications ◽

10.1016/s0006-291x(89)80113-5 ◽

1989 ◽

Vol 160 (3) ◽

pp. 1079-1084 ◽

Cited By ~ 2

Author(s):

Richard A. Winegar ◽

M. Catherine Land ◽

William F. Morgan

Keyword(s):

Restriction Endonuclease ◽

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Ovary Cell Line ◽

Eco Ri

Download Full-text

Membrane potential and amino acid transport in a mutant chinese hamster ovary cell line

Journal of Cellular Physiology ◽

10.1002/jcp.1041460312 ◽

1991 ◽

Vol 146 (3) ◽

pp. 417-424 ◽

Cited By ~ 11

Author(s):

Bianca Maria Rotoli ◽

Ovidio Bussolati ◽

Valeria Dall'asta ◽

Gian Carlo Gazzola

Keyword(s):

Membrane Potential ◽

Amino Acid ◽

Cell Line ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Amino Acid Transport ◽

Chinese Hamster ◽

Ovary Cell ◽

Acid Transport ◽

Ovary Cell Line

Download Full-text