scholarly journals Systematic identification of target set-dependent activity cliffs

2019 ◽  
Vol 5 (2) ◽  
pp. FSO363 ◽  
Author(s):  
Huabin Hu ◽  
Dagmar Stumpfe ◽  
Jürgen Bajorath
Keyword(s):  
Dependent Activity ◽  
Target Set ◽  
Systematic Identification ◽  
Activity Cliffs

MMP-Cliffs: Systematic Identification of Activity Cliffs on the Basis of Matched Molecular Pairs

2012 ◽  
Vol 52 (5) ◽  
pp. 1138-1145 ◽  
Author(s):  
Xiaoying Hu ◽  
Ye Hu ◽  
Martin Vogt ◽  
Dagmar Stumpfe ◽  
Jürgen Bajorath
Keyword(s):  
Matched Molecular Pairs ◽  
Systematic Identification ◽  
Activity Cliffs

Systematic Identification and Classification of Three-Dimensional Activity Cliffs

2012 ◽  
Vol 52 (6) ◽  
pp. 1490-1498 ◽  
Author(s):  
Ye Hu ◽  
Norbert Furtmann ◽  
Michael Gütschow ◽  
Jürgen Bajorath
Keyword(s):  
Three Dimensional ◽  
Systematic Identification ◽  
Activity Cliffs

scholarly journals Increasing the public activity cliff knowledge base with new categories of activity cliffs

2020 ◽  
Vol 6 (5) ◽  
pp. FSO472
Author(s):  
Huabin Hu ◽  
Jürgen Bajorath
Keyword(s):  
Knowledge Base ◽  
Structural Characteristics ◽  
Public Knowledge ◽  
Target Distribution ◽  
The Public ◽  
Public Activity ◽  
Activity Cliff ◽  
Systematic Identification ◽  
Dual Site ◽  
Activity Cliffs

Aim: Extending the public knowledge base of activity cliffs (ACs) with new categories of ACs having special structural characteristics. Methodology: Dual-site ACs, isomer ACs and ACs with privileged substructures are described and their systematic identification is detailed. Exemplary results & data: More than 7400 new ACs belonging to different categories with activity against more than 200 targets were identified and are made publicly available. Limitations & next steps: For dual-site ACs, limited numbers of isomers are available as structural analogs for rationalizing contributions to AC formation. The search for such analogs will continue. In addition, the target distribution of ACs containing privileged substructures will be further analyzed.

Evidence for the presence of core structure-dependent activity cliffs

2020 ◽  
Vol 12 (16) ◽  
pp. 1451-1455
Author(s):  
Huabin Hu ◽  
Jürgen Bajorath
Keyword(s):  
Core Structure ◽  
Dependent Activity ◽  
Activity Cliffs

Systematic identification of novel lincRNAs involved in chemoresistance using CRISPR/Cas9 screens

2016 ◽  
Vol 54 (08) ◽  
Author(s):  
T Zhan ◽  
LI Franke ◽  
M Arnold ◽  
M Breinig ◽  
F Heigwer ◽  
...  
Keyword(s):  
Systematic Identification

Globalization and interconfessional communications

2001 ◽  
pp. 13-17
Author(s):  
Serhii Viktorovych Svystunov
Keyword(s):  
21St Century ◽  
Global Economy ◽  
Modern World ◽  
The World ◽  
Target Set ◽  
Almost All ◽  
Over Time ◽  
Rapid Appearance

In the 21st century, the world became a sign of globalization: global conflicts, global disasters, global economy, global Internet, etc. The Polish researcher Casimir Zhigulsky defines globalization as a kind of process, that is, the target set of characteristic changes that develop over time and occur in the modern world. These changes in general are reduced to mutual rapprochement, reduction of distances, the rapid appearance of a large number of different connections, contacts, exchanges, and to increase the dependence of society in almost all spheres of his life from what is happening in other, often very remote regions of the world.

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