scholarly journals Invertible micellar polymer nanoassemblies target bone tumor cells but not normal osteoblast cells

2015 ◽  
Vol 1 (3) ◽  
Author(s):  
Olena Kudina ◽  
Kristen L Shogren ◽  
Carl T Gustafson ◽  
Michael J Yaszemski ◽  
Avudaiappan Maran ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Osteoblast Cells ◽  
Normal Osteoblast

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

2020 ◽  
pp. 100088
Author(s):  
Robin A. Nadar ◽  
Gerben M. Franssen ◽  
Natasja W.M. Van Dijk ◽  
Karlijn Codee-van der Schilden ◽  
Mirjam de Weijert ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Targeted Delivery ◽  
Metastatic Tumor

scholarly journals Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy

2020 ◽  
Vol 8 ◽  
Author(s):  
Hongshi Ma ◽  
Zhenjiang Ma ◽  
Qufei Chen ◽  
Wentao Li ◽  
Xiangfei Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Checkpoint Inhibitors ◽  
Tumor Therapy ◽  
Residual Tumor ◽  
Bone Defects ◽  
Silica Nanosphere ◽  
Large Bone ◽  
Large Bone Defects

In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology via 3D printing and spin coating. The scaffolds exhibited coating time- and laser power density-dependent photothermal performance, which favored the effective killing of tumor cells under near-infrared laser irradiation. Furthermore, the prepared scaffolds favored the proliferation and attachment of rabbit bone marrow-derived mesenchymal stem cells and stimulated the gene expression of osteogenic markers. Overall, Cu-MSN-TCP scaffolds can be considered for complete eradication of residual bone tumor cells and simultaneous healing of large bone defects, which may provide a novel and effective strategy for bone tumor therapy. In the future, such Cu-MSN-TCP scaffolds may function as carriers of anti-cancer drugs or immune checkpoint inhibitors in chemo-/photothermal or immune-/photothermal therapy of bone tumors, favoring for effective treatment.

scholarly journals PTHrP Induces Autocrine/Paracrine Proliferation of Bone Tumor Cells through Inhibition of Apoptosis

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19975 ◽  
Author(s):  
Isabella W. Y. Mak ◽  
Robert W. Cowan ◽  
Robert E. Turcotte ◽  
Gurmit Singh ◽  
Michelle Ghert
Keyword(s):  
Tumor Cells ◽  
Bone Tumor

scholarly journals Application of Modified Closed Biopsy in Rabbit Model of VX2 Transplanted Bone Tumor

2021 ◽  
Author(s):  
Bai Lei peng ◽  
Lv Jia xing ◽  
Kong Ling wei ◽  
Cao Hai ying ◽  
Jin Yu
Keyword(s):  
Soft Tissue ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Control Group ◽  
Expression Levels ◽  
X Ray ◽  
Biopsy Technique ◽  
Puncture Biopsy ◽  
The Difference ◽  
Experimental Group

Abstract Aim To explore the application value of modified closed biopsy technique in puncture biopsy of rabbit VX2 transplanted bone tumor model.Methods VX2 tumor was transplanted into the bilateral tibia of 30 rabbits through the tibial plateau to make the model of VX2 transplanted bone tumor. Seven days after modeling, the proximal tibia biopsy was performed under the guidance of X-ray, and the biopsy specimen was examined pathologically. The left leg was biopsied with modified closed biopsy technique (experimental group) and the right leg was biopsied with hollow needle (control group). After 14 days of modeling, all rabbits were killed after X-ray examination around the puncture hole, and the soft tissue around the puncture hole was taken for pathological examination, and the expression levels of PCNA and CD34 in the tissue extract were detected by enzyme-linked immunosorbent assay (ELISA).Results By the end of the experiment, a total of 3 rabbits died, and finally 27 rabbits were included in the study. Tumor cells were detected in all the intramedullary specimens obtained by puncture biopsy. On the 14th day after modeling, X-ray showed that the occurrence rate of periosteal reaction and extraosseous high density shadow around the puncture hole was 14.81% (4/27) in the experimental group and 40.74% (11/27) in the control group. the difference was statistically significant (P<0.05). The pathological results of soft tissue around the puncture hole showed that the tumor cell metastasis rate was 29.63% (8/27) in the experimental group and 100% (27/27) in the control group, and the difference was statistically significant (P<0.05).The expression levels of PCNA and CD34 in the experimental group were lower than those in the control group (P < 0.05). Conclusion Both the modified closed biopsy technique and needle aspiration biopsy can provide sufficient biopsy tissue for the diagnosis of VX2 transplanted bone tumor in rabbits. At the same time, the improved closed biopsy technique has a certain application value in preventing local metastasis of tumor cells along the puncture channel.

scholarly journals Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels

Biomaterials ◽  
2019 ◽  
Vol 188 ◽  
pp. 130-143 ◽  
Author(s):  
Tongmeng Jiang ◽  
Jinmin Zhao ◽  
Shan Yu ◽  
Zhengwei Mao ◽  
Changyou Gao ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Matrix Stiffness ◽  
Ligand Density ◽  
Adhesion Ligand

scholarly journals Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells

2006 ◽  
Vol 24 (6) ◽  
pp. 1138-1144 ◽  
Author(s):  
Tadahiko Kubo ◽  
Shoji Shimose ◽  
Toshihiro Matsuo ◽  
Kumi Tanaka ◽  
Yuji Yasunaga ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Malignant Bone Tumor ◽  
Inhibitory Effects ◽  
Proliferation And Invasion

3D-printed bioceramic scaffolds with a Fe3O4/graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells

2016 ◽  
Vol 4 (17) ◽  
pp. 2874-2886 ◽  
Author(s):  
Yongliang Zhang ◽  
Dong Zhai ◽  
Mengchi Xu ◽  
Qingqiang Yao ◽  
Jiang Chang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Graphene Oxide ◽  
Bone Formation ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Alternating Magnetic Field ◽  
Hyperthermia Therapy ◽  
3D Printed

Magnetic scaffolds display prominent magnetothermal ability, and can effectively kill tumor cells in an alternating magnetic field and improve bone formation ability in vitro.

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