Diabetes mellitus & disorders of lipid metabolism

2015 ◽  
pp. 170-188
Author(s):  
Armin Steinmetz
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Disorders Of Lipid Metabolism

Abstract WP189: Trends in Comorbidities Among Stroke-related Hospitalizations in California, 2000-2013

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Anura W Ratnasiri ◽  
Buddhika M Ratnasiri ◽  
Ralph DiLibero
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Positive Association ◽  
Patient Discharge ◽  
Recent Decade ◽  
Trend Test ◽  
Cardiac Dysrhythmia ◽  
Insurance Type ◽  
Clinical Classification Software ◽  
Disorders Of Lipid Metabolism

Background: Preventive care for adults with hypertension and diabetes has improved over the recent decade. This study aims to identify trends of these and other comorbidities for patients with stroke-related hospitalizations in California from 2000 to 2013. Methods: This retrospective study is based on patient discharge information compiled by the California Office of Statewide Health and Planning Development from 2000 to 2013. The study population is comprised of residents, and represents over 31.68 million hospital events. Stroke hospitalizations were identified using the first listed diagnoses in the hospital records, ICD-9-CM codes 430 to 436. Comorbidities were identified using ICD-9-CM codes in 24 other diagnostic fields in each stroke hospitalization, aided by AHRQ’s Clinical Classification Software. Cochran Armitage trend test was employed to identify comorbidity trends from 2000 to 2013. Stroke hospitalizations were adjusted for sex, age, race/ethnicity and insurance type using multivariable logistic regression for each of the comorbidities analyzed. Results: Over 1 million hospitalizations and 77,908 in-hospital mortalities for stroke were identified from 2000 to 2013. Disorders of lipid metabolism among stroke-related hospitalizations rose by 230.5% from 16.7% in 2000 to 55.1% in 2013. Diabetes mellitus increased by 45.1% from 27.0% in 2000 to 39.2% in 2013. Cardiac dysrhythmia rose by 36.6% from 21.0% in 2000 to 28.7% in 2013 while hypertension rose by 22.0% from 67.7% in 2000 to 82.6% in 2013. The trend test showed significant upward trends (p <0.001) for these four comorbidities during the study period. After adjusting for patient demographics and insurance type, all four comorbidities had a positive association with stroke-related hospitalizations: diabetes mellitus (AOR 1.247; 95% CI=1.228-1.267), hypertension (AOR 2.685;[95% CI=2.631-2.740), disorders of lipid metabolism (AOR 2.095; 95% CI=2.063-2.127) and cardiac dysrhythmias (AOR 1.193; 95% CI=1.172-1.213). Conclusion: Diabetes mellitus, hypertension, disorders of lipid metabolism and cardiac dysrhythmia are positively associated with stoke-related hospitalizations.

Placental Accumulation of Triacylglycerols in Gestational Diabetes Mellitus and Its Association with Altered Fetal Growth are Related to the Differential Expressions of Proteins of Lipid Metabolism

2020 ◽  
Author(s):  
Manoharan Balachandiran ◽  
Zachariah Bobby ◽  
Gowri Dorairajan ◽  
Sajini Elizabeth Jacob ◽  
Victorraj Gladwin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fetal Growth ◽  
Fatty Acid Synthase ◽  
Regulatory Element ◽  
Acid Oxidation ◽  
Placental Proteins

Abstract Introduction Gestational diabetes mellitus (GDM) exhibit altered placental lipid metabolism. The molecular basis of this altered metabolism is not clear. Altered placental expression of proteins of lipogenesis and fatty acid oxidation may be involved in the placental accumulation of triacylglycerols (TG). The present study was aimed at investigating the differential expressions of placental proteins related to lipid metabolism among GDM women in comparison with control pregnant women (CPW) and to correlate them with maternal and fetal lipid parameters as well as altered fetal growth. Materials and Methods Maternal blood, cord blood, and placental samples were collected from GDM and CPW. The biochemical parameters, glucose, lipid profile and free fatty acids (FFA) were measured. The placental TG content was measured. Differential placental expressions of proteins; phosphatidylinositol-3-kinase (PI3K) p85α, PI3K p110α,liver X receptor alpha (LXRα), sterol regulatory element binding protein1(SREBP1), fatty acid synthase (FAS), stearyl CoA desaturase1 (SCD1), lipoprotein lipase (LPL),Peroxisome proliferator-activated receptor (PPAR)α and PPARγ were analysed by western blotting and immunohistochemistry. Results Placental protein expressions of PI3K p110α, LXRα, FAS, SCD1, and LPL were found to be significantly higher, whereas PPARα and PPARγ were lower in GDM women compared with CPW. The placental TG content and cord plasma FFA were increased in GDM women compared with CPW. The placental TG content positively correlated with Ponderal index of GDM new-borns. Conclusion Differential expressions of placental proteins related to lipid metabolism in GDM might have led to placental TG accumulation. This might have contributed to the fetal overgrowth in GDM.

scholarly journals ВЛИЯНИЕ ВЕЩЕСТВА НА ОСНОВЕ ФИБРОИНА ШЕЛКА НА ПОКАЗАТЕЛИ ЛИПИДНОГО ОБМЕНА У КРЫС С ЭКСПЕРИМЕНТАЛЬНОЙ ГИПЕРХОЛЕСТЕРИНЕМИЕЙ

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 38-42
Author(s):  
Нишантаев М. К. ◽  
Арифджанов С. З. ◽  
Айходжаев Б. К. ◽  
Юлдашев Н. М.
Keyword(s):  
Lipid Metabolism ◽  
Bile Acid ◽  
Polymer Physics ◽  
The Body ◽  
Hypocholesterolemic Effect ◽  
Bile Acid Sequestrants ◽  
Experimental Hypercholesterolemia ◽  
The Republic ◽  
Academy Of Sciences ◽  
Disorders Of Lipid Metabolism

The article presents the results of a study on the effectiveness of a substance based on silk fibroin, obtained at the Institute of Chemistry and Polymer Physics of the Academy of Sciences of the Republic of Uzbekistan, in eliminating disorders of lipid metabolism in the body. In experiments in rats with experimental hypercholesterolemia, the substance was found to have a cholesterol-lowering property, which is manifested by a decrease in cholesterol level both in blood and in tissues. Studies on the mechanism of the hypocholesterolemic effect of the studied substance have shown its effects on the enterohepatic pathway of bile acids, which makes it possible to classify this substance as a group of bile acid sequestrants.

scholarly journals Effects of Momordica Charantia Silver Nanoparticles on the expressions of Genes Associated With Lipid Metabolism and Nephrotoxicity in Streptozotocin-Induced Rats

2021 ◽  
Vol 37 (2) ◽  
pp. 126-133
Author(s):  
O.O Elekofehinti ◽  
M.O Akinjiyan
Keyword(s):  
Diabetes Mellitus ◽  
Silver Nanoparticles ◽  
Lipid Metabolism ◽  
Silver Nitrate ◽  
Nitrate Solution ◽  
Diabetic Control ◽  
Untreated Group ◽  
Rt Pcr ◽  
Hmg Coa Reductase ◽  
Coa Reductase

Hyperlipidemia and hyperglycemia have been implicated in diabetes mellitus (DM) leading to complications such as nephropathy. Medicinal plants like Mormodica charantia (MC) have been used in the treatment of DM over the years but little is known about their mechanisms of action. This study used biotechnology tools to investigate and compare the effects of M. charantia silver nanoparticles (MCSNPs) with M. charantia extract on expressions of genes linked with nephrotoxicity, lipid and glucose metabolisms using reverse-transcriptase polymerase chain reaction (RT-PCR) in streptozotocin-induced diabetic rats. The genes investigated include kidney injury molecule-1 (KIM-1), 3-hydroxyl, 3-methyl glutaryl_coA reductase (HMG-CoA reductase), peroxisome proliferator-activated receptor alpha and gamma (PPARα and PPARγ). Synthesis of MCSNPs was done using 1 mM concentration of aqueous silver nitrate solution at ratio 1:9 (v/v). Experimental rats were induced intraperitoneally with streptozotocin (65 mg/kg) and divided into six groups viz: diabetic control; normal control; silver nitrate (10 mg/kg); MCSNPs (50 mg/kg); Metformin (100 mg/kg) and M. charantia fraction (100 mg/kg). Sacrifice was done after 12 days of treatment and RT-PCR was then used to investigate gene expressions in liver and kidney tissues of the rats. The expression of HMG-CoA reductase gene was significantly upregulated (p<0.05) upon treatment with 50 mg/kg MCSNPs relative to the diabetic untreated group. M. charantia extracts and MCSNPs significantly upregulate (p<0.05) the expressions of PPAR-α and PPAR-γ compared to the diabetic control. Also, a significant (p<0.05) down-regulation of KIM-1 mRNA expression was observed in MCSNPs- treated group, relative to the diabetes untreated group. M. charantia silver nanoparticles could be a potent antidiabetic agent due to its potential to modulate genes associated with lipid metabolism and nephrotoxicity. Keywords: Medicinal plant; Diabetes Mellitus; Silver Nanoparticles; nephrotoxicity; gene expression

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