Stem cell based gene delivery methods

2015 ◽  
pp. 30-40
Author(s):  
Sarah A Bliss ◽  
Pranela Rameshwar
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Delivery Methods

scholarly journals PAMAM dendrimer roles in gene delivery methods and stem cell research

2013 ◽  
Vol 37 (5) ◽  
pp. 415-419 ◽  
Author(s):  
Nasibeh Daneshvar ◽  
Rasedee Abdullah ◽  
Fatemeh T. Shamsabadi ◽  
Chee Wun How ◽  
M. Aizat MH ◽  
...  
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Stem Cell Research ◽  
Pamam Dendrimer ◽  
Delivery Methods

scholarly journals Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform

2021 ◽  
Author(s):  
Qingyao Kong ◽  
Yuanyuan Li ◽  
Jiping Yue ◽  
Xiaoyang Wu ◽  
Ming Xu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Gene Delivery ◽  
Unmet Need ◽  
Skin Grafts ◽  
Epidermal Stem Cell ◽  
Epidermal Stem Cells ◽  
Concurrent Use ◽  
Delivery Platform ◽  
Glucagon Like Peptide 1

AbstractAlcohol use disorder (AUD) is one of the foremost public health problems. Alcohol is also frequently co-abused with cocaine. There is a huge unmet need for the treatment of AUD and/or cocaine co-abuse. We recently demonstrated that skin grafts generated from mouse epidermal stem cells that had been engineered by CRISPR-mediated genome editing could be transplanted onto mice as a gene delivery platform. Here, we show that expression of the glucagon-like peptide-1 (GLP1) gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption. GLP1 derived from the skin grafts decreased alcohol-induced increase in dopamine levels in the nucleus accumbens. In exploring the potential of this platform in reducing concurrent use of drugs, we developed a novel co-grafting procedure for both modified human butyrylcholinesterase (hBChE)- and GLP1-expressing cells. Epidermal stem cell-derived hBChE and GLP1 reduced acquisition of drug-taking and toxicity induced by alcohol and cocaine co-administration. These results imply that cutaneous gene delivery through skin transplants may add a new option to treat drug abuse and co-abuse.

scholarly journals In vivo gene delivery by embryonic-stem-cell–derived astrocytes for malignant gliomas

2009 ◽  
Vol 11 (2) ◽  
pp. 102-108 ◽  
Author(s):  
Mahmud Uzzaman ◽  
Gordon Keller ◽  
Isabelle M. Germano
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Embryonic Stem Cell ◽  
Malignant Gliomas ◽  
Embryonic Stem ◽  
In Vivo Gene Delivery

Non-Viral Gene Delivery Methods

2013 ◽  
Vol 14 (1) ◽  
pp. 46-60 ◽  
Author(s):  
Weiwei Wang ◽  
Wenzhong Li ◽  
Nan Ma ◽  
Gustav Steinhoff
Keyword(s):  
Gene Delivery ◽  
Viral Gene ◽  
Delivery Methods ◽  
Viral Gene Delivery

Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking

Biomaterials ◽  
2014 ◽  
Vol 35 (25) ◽  
pp. 7239-7247 ◽  
Author(s):  
Wooram Park ◽  
Han Na Yang ◽  
Daishun Ling ◽  
Hyeona Yim ◽  
Kyoung Sub Kim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Magnetic Nanoparticles ◽  
Gene Delivery ◽  
Agent Based ◽  
Cell Gene ◽  
Stem Cell Gene ◽  
Transfection Agent

Bone Marrow Stem Cell Delivery Methods, Routes, Time, Efficacy, and Safety

2016 ◽  
pp. 261-271
Author(s):  
Lijie Huang ◽  
Jianjing Yang ◽  
Mark Nyanzu ◽  
Felix Siaw-Debrah ◽  
Qichuan Zhuge
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Stem Cell ◽  
Cell Delivery ◽  
Efficacy And Safety ◽  
Delivery Methods ◽  
Stem Cell Delivery ◽  
Marrow Stem Cell

A multicellular, neuro-mimetic model to study nanoparticle uptake in cells of the central nervous system

2014 ◽  
Vol 6 (9) ◽  
pp. 855-861 ◽  
Author(s):  
A. R. Fernandes ◽  
D. M. Chari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Gene Delivery ◽  
Neural Model ◽  
Cell Populations ◽  
Nanoparticle Uptake ◽  
System P ◽  
The Central Nervous System ◽  
In Cells

We describe a multicellular neural model to study nanoparticle uptake and gene delivery, using stem cell derived cell populations.

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