Microwave-assisted medicinal chemistry: examples from a pharmaceutical company

2014 ◽  
pp. 20-33
Author(s):  
Jesús Alcázar ◽  
Yannick Ligny
Keyword(s):  
Pharmaceutical Company ◽  
Medicinal Chemistry ◽  
Microwave Assisted

Microwave-Assisted Domino Cyclization Reactions

2021 ◽  
Vol 08 ◽  
Author(s):  
Yogesh B. Wagh ◽  
Dipak S. Dalal
Keyword(s):  
Microwave Irradiation ◽  
Molecular Diversity ◽  
Medicinal Chemistry ◽  
Complex Molecule ◽  
Complex Compounds ◽  
Synthetic Chemistry ◽  
Domino Reactions ◽  
Cyclization Reactions ◽  
Microwave Assisted ◽  
Synthetic Approaches

Background: Microwave-assisted domino cyclization reactions have attracted great interest for researchers to synthesize complex compounds in shorter times with increase yields. The domino reactions were used in various synthetic approaches and many drug deliveries in medicinal chemistry with microwave assisted approach. Methods: Microwave irradiation has been applied for the various domino reactions. The research related to microwave assisted domino cyclization was reviewed and the important methodologies are collected from 2011-2021. Results: Only those methodologies that involve microwave-assisted domino cyclization reactions during synthesis in a related manner have been reviewed. Along with some recent syntheses that are microwave-assisted regarding new heterocyclic moieties are summarized. Conclusion: Microwave-assisted domino cyclization reactions can be employed to quickly explore and increase molecular diversity in synthetic chemistry. We hope that this review will be helpful to find out complex molecule synthesis by microwave-assisted domino cyclization reactions. This review aimed to explain the applications of microwaves for the domino reactions from 2011-2021. In this respect, the microwave mediated methods help researchers to make helpful studies.

scholarly journals Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 716 ◽  
Author(s):  
Dorina Amariucai-Mantu ◽  
Violeta Mangalagiu ◽  
Ramona Danac ◽  
Ionel I. Mangalagiu
Keyword(s):  
Biological Activity ◽  
Medicinal Chemistry ◽  
Membered Ring ◽  
Reaction Pathways ◽  
Microwave Assisted ◽  
Main Series ◽  
Privileged Scaffolds

Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles chemistry during the last decades. Five and six membered ring azaheterocycles are privileged scaffolds in modern medicinal chemistry possessing a large variety of biological activity. This review is focused on the recent relevant advances in the MW assisted reactions applied to azaheterocyclic derivatives and their medicinal chemistry applications from the last five years. The review is divided according to the main series of azaheterocycles, more precisely 5- and 6-membered ring azaheterocycles (with one, two, and more heteroatoms) and their fused analogues. In each case, the reaction pathways, the advantages of using MW, and considerations concerning biological activity of the obtained products were briefly presented.

ChemInform Abstract: Microwave-Assisted Synthesis of N-Heterocycles in Medicinal Chemistry

ChemInform ◽  
2014 ◽  
Vol 45 (3) ◽  
pp. no-no
Author(s):  
Davide Garella ◽  
Emily Borretto ◽  
Antonella Di Stilo ◽  
Katia Martina ◽  
Giancarlo Cravotto ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

2-quinolone-based derivatives as antibacterial agents: A review

2021 ◽  
Vol 18 ◽  
Author(s):  
Oussama Moussaoui ◽  
Said Chakroune ◽  
Youssef Kandri Rodi ◽  
El Mestafa El Hadrami
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Antibacterial Agents ◽  
Medicinal Chemistry ◽  
Antibacterial Activities ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Important Family ◽  
Reduced Toxicity ◽  
Synthetic Approaches

: The chemistry of 2-quinolones derivatives has received more attention in the field of both organic chemistry and medicinal chemistry. As several advances in the application of this important family of compounds seem too significant utility. In recent years, a variety of new, effective, and novel synthetic approaches (including green chemistry, catalyzed and microwave-assisted synthesis) have been discovered and developed for the designer of various 2-quinolone-based scaffolds, representing an area of increased interest to universities and industry, as well as, to explore their antibacterial activities and reduced toxicity than the existing ones. This review summarizes the results of the literature on the synthesis strategies of 2-quinolones derivatives and their reactivity, as well as their antibacterial evaluations against different bacteria strains.

Microwave-Assisted Medicinal Chemistry

ChemInform ◽  
2007 ◽  
Vol 38 (31) ◽  
Author(s):  
Jesus Alcazar ◽  
Gaston Diels ◽  
Bruno Schoentjes
Keyword(s):  
Medicinal Chemistry ◽  
Microwave Assisted

Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry

2016 ◽  
Vol 12 (8) ◽  
pp. 720-732 ◽  
Author(s):  
Francesco Frecentese ◽  
Irene Saccone ◽  
Giuseppe Caliendo ◽  
Angela Corvino ◽  
Ferdinando Fiorino ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Aqueous Media ◽  
Microwave Assisted ◽  
Recent Advances

scholarly journals Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

MedChemComm ◽  
2013 ◽  
Vol 4 (10) ◽  
pp. 1323 ◽  
Author(s):  
Davide Garella ◽  
Emily Borretto ◽  
Antonella Di Stilo ◽  
Katia Martina ◽  
Giancarlo Cravotto ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

scholarly journals Microwave-Assisted Synthesis of Bis-Heterocycles Containing the Imidazo[1,2-a]Pyridine by Groebke-Blackburn-Bienaymé Reaction

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 79
Author(s):  
Sandra C. Ramírez-López ◽  
Rocío Gámez-Montaño
Keyword(s):  
Medicinal Chemistry ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Green Catalysis ◽  
Privileged Scaffolds

A series of six fused bis-heterocycles having imidazo[1,2-a]pyridine bound with quinoline were synthesized by microwave-assisted Groebke-Blackburn-Bienaymé reaction (GBBR) under green catalysis. The GBB products are privileged scaffolds and their synthesis is of great interest in synthetic and medicinal chemistry.

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