Organogermanium compound, Ge-132, forms complexes with adrenaline, ATP and other physiologicalcis-diol compounds

2015 ◽  
Vol 7 (10) ◽  
pp. 1233-1246 ◽  
Author(s):  
Takashi Nakamura ◽  
Yasuhiro Shimada ◽  
Tomoya Takeda ◽  
Katsuyuki Sato ◽  
Mitsuo Akiba ◽  
...  
Keyword(s):  
Organogermanium Compound

scholarly journals The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells

2019 ◽  
Vol 20 (19) ◽  
pp. 4785
Author(s):  
Junya Azumi ◽  
Tomoya Takeda ◽  
Yasuhiro Shimada ◽  
Hisashi Aso ◽  
Takashi Nakamura
Keyword(s):  
Gene Expression ◽  
Kojic Acid ◽  
Biological Activities ◽  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Melanin Synthesis ◽  
Mushroom Tyrosinase ◽  
Melanin Production ◽  
Organogermanium Compound ◽  
Or Gene

The organogermanium compound 3-(trihydroxygermyl)propanoic acid (THGP) has various biological activities. We previously reported that THGP forms a complex with cis-diol structures. L-3,4-Dihydroxyphenylalanine (L-DOPA), a precursor of melanin, contains a cis-diol structure in its catechol skeleton, and excessive melanin production causes skin darkening and staining. Thus, the cosmetic field is investigating substances that suppress melanin production. In this study, we investigated whether THGP inhibits melanin synthesis via the formation of a complex with L-DOPA using mushroom tyrosinase and B16 4A5 melanoma cells. The ability of THGP to interact with L-DOPA was analyzed by 1H-NMR, and the influence of THGP and/or kojic acid on melanin synthesis was investigated. We also examined the effect of THGP on cytotoxicity, tyrosinase activity, and gene expression and found that THGP interacted with L-DOPA, a precursor of melanin with a cis-diol structure. The results also showed that THGP inhibited melanin synthesis, exerted a synergistic effect with kojic acid, and did not affect tyrosinase activity or gene expression. These results suggest that THGP is a useful substrate that functions as an inhibitor of melanogenesis and that its effect is enhanced by combination with kojic acid.

scholarly journals Analgesic effect of novel organogermanium compound, Ge-132.

1983 ◽  
Vol 6 (11) ◽  
pp. 814-820 ◽  
Author(s):  
MITSUGU HACHISU ◽  
HIROKO TAKAHASHI ◽  
TAKEMI KOEDA ◽  
YASUHARU SEKIZAWA
Keyword(s):  
Analgesic Effect ◽  
Organogermanium Compound

Induction of Interferon Production by Natural Killer Cells by Organogermanium Compound, Gel32

1987 ◽  
Vol 7 (1) ◽  
pp. 69-76 ◽  
Author(s):  
TETSUO MUNAKATA ◽  
SUMIO ARAI ◽  
KOICHI KUWANO ◽  
MAYUMI FURUKAWA ◽  
YUKO TOMITA
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Interferon Production ◽  
Killer Cells ◽  
Organogermanium Compound

2-Carboxyethylgermanium sesquioxide, a synthetic organogermanium compound, as an inducer of contrasuppressor T cells

1996 ◽  
Vol 52 (2) ◽  
pp. 159-166 ◽  
Author(s):  
K. Ikemoto ◽  
M. Kobayashi ◽  
T. Fukumoto ◽  
M. Morimatsu ◽  
R. B. Pollard ◽  
...  
Keyword(s):  
T Cells ◽  
Organogermanium Compound

Effects of organogermanium compound GE-132 on differentiation and calcification of rat bone marrow stromal cells

1996 ◽  
Vol 6 (S1) ◽  
pp. 98-98
Author(s):  
Y. Yamada ◽  
K. Okano ◽  
I. Eguchi ◽  
S. Suzuki ◽  
S. Naitoh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Organogermanium Compound ◽  
Rat Bone
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