scholarly journals Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration

2012 ◽  
Vol 4 (17) ◽  
pp. 2153-2161 ◽  
Author(s):  
Kai Kaarniranta ◽  
Anu Kauppinen ◽  
Janusz Blasiak ◽  
Antero Salminen
Keyword(s):  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1102 ◽  
Author(s):  
Sonali Nashine ◽  
M. Cristina Kenney
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Mechanisms Of Action ◽  
Age Related Macular Degeneration ◽  
Age Related

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.

scholarly journals Dry Age-Related Macular Degeneration: Mechanisms, Therapeutic Targets, and Imaging

2013 ◽  
Vol 54 (14) ◽  
pp. ORSF68 ◽  
Author(s):  
Catherine Bowes Rickman ◽  
Sina Farsiu ◽  
Cynthia A. Toth ◽  
Mikael Klingeborn
Keyword(s):  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Future Therapies of Wet Age-Related Macular Degeneration

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Makoto Ishikawa ◽  
Daisuke Jin ◽  
Yu Sawada ◽  
Sanae Abe ◽  
Takeshi Yoshitomi
Keyword(s):  
Macular Degeneration ◽  
Elderly Population ◽  
Therapeutic Targets ◽  
The Elderly ◽  
Age Related Macular Degeneration ◽  
Vegf Inhibitors ◽  
Ocular Neovascularization ◽  
Visual Outcomes ◽  
Duration Of Effect ◽  
Age Related

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population, and the prevalence of the disease increases exponentially with every decade after the age of 50 years. While VEGF inhibitors are promising drugs for treating patients with ocular neovascularization, there are limitations to their potential for improving vision in AMD patients. Thus, future therapies are required to have the potential to improve visual outcomes. This paper will summarize the future strategies and therapeutic targets that are aimed at enhancing the efficacy and duration of effect of antiangiogenic strategies.

scholarly journals miRNAs as potential therapeutic targets for age-related macular degeneration

2012 ◽  
Vol 4 (3) ◽  
pp. 277-287 ◽  
Author(s):  
Shusheng Wang ◽  
Kyle M Koster ◽  
Yuguang He ◽  
Qinbo Zhou
Keyword(s):  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Age Related Macular Degeneration ◽  
Age Related

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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