Synthesis, leishmanicidal activity, structural descriptors and structure–activity relationship of quinoline derivatives

2018 ◽  
Vol 10 (17) ◽  
pp. 2069-2085 ◽  
Author(s):  
Etyene JG Silva ◽  
Adriana Bezerra-Souza ◽  
Luiz FD Passero ◽  
Márcia D Laurenti ◽  
Gláucio M Ferreira ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Leishmanicidal Activity ◽  
Structural Descriptors ◽  
Structure Activity ◽  
Relationship Of

Quantitative Structure-Activity Relationship of Morita-Baylis-Hillman Adducts with Leishmanicidal Activity

2011 ◽  
Vol 66 (3-4) ◽  
pp. 136-142
Author(s):  
Rodrigo Octavio M. A. de Souza ◽  
José C. Barros ◽  
Joaquim F. M. da Silva ◽  
Octavio A. C. Antunes
Keyword(s):  
Molecular Orbital ◽  
Quantitative Structure Activity Relationship ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Orbital Energy ◽  
Quantitative Structure ◽  
Leishmanicidal Activity ◽  
Structure Activity ◽  
Relationship Model ◽  
Relationship Of

A quantitative structure-activity relationship model for Morita-Baylis-Hillman adducts with leishmanicidal activities was developed which correlates molecular orbital energy and dipole with percentage in the promastigote stage

Structure−Activity Relationship of Quinoline Derivatives as Potent and Selective α2C-Adrenoceptor Antagonists

2006 ◽  
Vol 49 (21) ◽  
pp. 6351-6363 ◽  
Author(s):  
Iisa P. J. Höglund ◽  
Satu Silver ◽  
Mia T. Engström ◽  
Harri Salo ◽  
Andrei Tauber ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Structure Activity ◽  
Relationship Of

Structure−Activity Relationship of Newly Synthesized Quinoline Derivatives for Reversal of Multidrug Resistance in Cancer

1997 ◽  
Vol 40 (13) ◽  
pp. 2047-2052 ◽  
Author(s):  
Tsuneji Suzuki ◽  
Nobuyuki Fukazawa ◽  
Kunio San-nohe ◽  
Wakao Sato ◽  
Osamu Yano ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Structure Activity ◽  
Relationship Of

Synthesis and Antineoplastic Activity of Quinoline Derivatives

2008 ◽  
Vol 61 (7) ◽  
pp. 531 ◽  
Author(s):  
Qiang Zhou ◽  
Jing Hou ◽  
Huamin Li ◽  
Li Cui ◽  
Han Jia ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Antineoplastic Activity ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Structure Activity ◽  
Relationship Of

Designed as a new series of molecules that contain the quinoline substructure, several 11H-indolo[3.2-c]quinoline derivatives were synthesized and subjected to biological evaluation. Several compounds were found to exhibit cytotoxic activity against the growth of colon (HTC-8), liver (BEL-7402), gastric (BCG-823), pulmonary gland (A549), and ovary (A2780) cancer cell lines. The structure–activity relationship of these compounds is discussed.

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