Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation

2017 ◽  
Vol 9 (11) ◽  
pp. 1193-1211 ◽  
Author(s):  
Maninder Kaur ◽  
Manjinder Singh ◽  
Om Silakari
Keyword(s):  
Rheumatoid Arthritis ◽  
Biological Evaluation ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Design, Synthesis and Biological Evaluation of Novel Phenylsulfonylurea Derivatives as PI3K/mTOR Dual Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1553
Author(s):  
Bingbing Zhao ◽  
Fei Lei ◽  
Caolin Wang ◽  
Binliang Zhang ◽  
Zunhua Yang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Correction: Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 4927-4927
Author(s):  
Vegard Torp Lien ◽  
Margrethe Konstanse Kristiansen ◽  
Solveig Pettersen ◽  
Mads Haugland Haugen ◽  
Stefan Krauss ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation

Correction for ‘Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation’ by Vegard Torp Lien et al., RSC Adv., 2019, 9, 37092–37100.

scholarly journals Synthesis and Biological Evaluation of Imines Structurally Related to Resveratrol as Dual Inhibitors of VEGF Protein Secretion and hTERT Gene Expression1

2017 ◽  
Vol 12 (5) ◽  
pp. 1934578X1701200
Author(s):  
Rosa Martí-Centelles ◽  
Juan Murga ◽  
Eva Falomir ◽  
Miguel Carda ◽  
J. Alberto Marco
Keyword(s):  
Tumor Cell ◽  
Tumor Cell Line ◽  
Biological Evaluation ◽  
Hek 293 ◽  
Htert Gene ◽  
Cytotoxic Compounds ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Ht 29 ◽  
Mcf 7

A group of 28 N-benzylidene aniline derivatives structurally related to the natural stilbene resveratrol has been prepared through condensation of anilines with the corresponding aldehydes. The ability of these imines to inhibit proliferation of two tumor cell lines (HT-29 and MCF-7) and one non-tumor cell line (HEK-293) was first determined. Subsequently, we determined the ability of some of the most cytotoxic compounds to inhibit the secretion of the VEGF-A factor in HT-29 cells and to downregulate the expression of the VEGF and hTERT genes, the latter one being involved in the activation of telomerase.

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