Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1)

2016 ◽  
Vol 8 (13) ◽  
pp. 1537-1551 ◽  
Author(s):  
Dmytro Ostrovskyi ◽  
Tobias Rumpf ◽  
Julia Eib ◽  
Alexandre Lumbroso ◽  
Inna Slynko ◽  
...  
Keyword(s):  
Histone Kinase

Ha-rasVal-12,Thr-59 activates S6 kinase and p34cdc2 kinase in Xenopus oocytes: evidence for c-mosxe-dependent and -independent pathways

1990 ◽  
Vol 10 (1) ◽  
pp. 310-315
Author(s):  
C B Barrett ◽  
R M Schroetke ◽  
F A Van der Hoorn ◽  
S K Nordeen ◽  
J L Maller
Keyword(s):  
Protein Kinase ◽  
Oocyte Maturation ◽  
Antisense Oligonucleotides ◽  
Xenopus Oocytes ◽  
Germinal Vesicle ◽  
Protein Product ◽  
Germinal Vesicle Breakdown ◽  
S6 Kinase ◽  
Kinase Activation ◽  
Histone Kinase

Treatment with insulin or progesterone or microinjection of the transforming protein product of Ha-rasVal-12,Thr-59 (p21) is known to induce germinal vesicle breakdown in Xenopus oocytes. We have investigated the effect of p21 on S6 kinase and the H1 histone kinase of maturation-promoting factor in the presence and absence of antisense oligonucleotides against the c-mosxe proto-oncogene. Injection of p21 led to a rapid increase in S6 phosphorylation, with kinetics similar to those previously observed with insulin. Microinjection of c-mosxe antisense oligonucleotides inhibited germinal vesicle breakdown induced by p21 and totally abolished S6 kinase activation by insulin or progesterone but only partially inhibited activation by p21. However, the activation of p34cdc2 protein kinase by all three stimuli was blocked by antisense oligonucleotides. The results suggest that in oocyte maturation c-mosxe functions downstream of p21 but upstream of p34cdc2 and S6 kinase activation, although not all p21-induced events require c-mosxe.

Specific substrate for histone kinase II: a synthetic nonapeptide

1985 ◽  
Vol 827 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Tibor Romhányi ◽  
János Sepródi ◽  
Ferenc Antoni ◽  
György Mészáros ◽  
Anna Faragó
Keyword(s):  
Specific Substrate ◽  
Histone Kinase

Brain histone kinase: The structure, the substrate specificity and the mechanism of action

1976 ◽  
Vol 14 ◽  
pp. 407-444 ◽  
Author(s):  
E.S. Severin ◽  
M.V. Nesterova ◽  
N.N. Gulyaev ◽  
S.V. Shlyapnikov
Keyword(s):  
Substrate Specificity ◽  
Mechanism Of Action ◽  
Histone Kinase
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