High-resolution MS for drug metabolite identification

Applications of High-Resolution Mass Spectrometry in Drug Discovery and Development ◽

10.4155/ebo.13.486 ◽

2013 ◽

pp. 22-40

Author(s):

Shalu Jhajra ◽

Bhagwat Prasad ◽

Jill Shah ◽

Saranjit Singh

Keyword(s):

High Resolution ◽

Metabolite Identification ◽

Drug Metabolite

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In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MSE and control comparison: cost and benefit of vehicle-dosed control samples

Xenobiotica ◽

10.3109/00498254.2016.1143138 ◽

2016 ◽

Vol 46 (10) ◽

pp. 922-930 ◽

Cited By ~ 2

Author(s):

Lukas Fiebig ◽

Ralf Laux ◽

Rudolf Binder ◽

Thomas Ebner

Keyword(s):

High Resolution ◽

Metabolite Identification ◽

Cost And Benefit ◽

Drug Metabolite ◽

Control Comparison ◽

And Control ◽

Control Samples

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Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

Journal of Mass Spectrometry ◽

10.1002/jms.1610 ◽

2009 ◽

Vol 44 (7) ◽

pp. 999-1016 ◽

Cited By ~ 183

Author(s):

Haiying Zhang ◽

Donglu Zhang ◽

Kenneth Ray ◽

Mingshe Zhu

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

High Resolution Mass Spectrometry ◽

Metabolite Identification ◽

Mass Defect ◽

Filter Technique ◽

Drug Metabolite ◽

High Resolution Mass ◽

Mass Defect Filter ◽

Resolution Mass

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Drug Metabolite Identification with High-resolution Mass Spectrometry

Handbook of Metabolic Pathways of Xenobiotics ◽

10.1002/9781118541203.xen0025 ◽

2014 ◽

pp. 1-23 ◽

Cited By ~ 1

Author(s):

Haiying Zhang ◽

Mingshe Zhu

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

High Resolution Mass Spectrometry ◽

Metabolite Identification ◽

Drug Metabolite ◽

High Resolution Mass ◽

Resolution Mass

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High-Resolution Mass Spectrometry and Drug Metabolite Identification

Mass Spectrometry in Drug Metabolism and Disposition ◽

10.1002/9780470929278.ch13 ◽

2011 ◽

pp. 407-448 ◽

Cited By ~ 5

Author(s):

Russell J. Mortishire-Smith ◽

Haiying Zhang ◽

Kevin P. Bateman

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

High Resolution Mass Spectrometry ◽

Metabolite Identification ◽

Drug Metabolite ◽

High Resolution Mass ◽

Resolution Mass

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New Software for Drug Metabolite Identification and Structural Characterization by Tandem Mass Spectrometry

10.26226/morressier.57d6b2bed462b8028d88ef03 ◽

2016 ◽

Author(s):

Duxin Sun

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Structural Characterization ◽

Metabolite Identification ◽

Tandem Mass ◽

Drug Metabolite

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Searching a Comprehensive High Resolution Tandem Mass Spectral Library for Reliable Human Metabolite Identification

10.21748/am20.155 ◽

2020 ◽

Author(s):

Xiaoyu Yang ◽

Neta Pedatsur ◽

Stephen Stein

Keyword(s):

High Resolution ◽

Metabolite Identification ◽

Tandem Mass ◽

Mass Spectral Library ◽

Spectral Library ◽

Mass Spectral ◽

Human Metabolite

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Interspecies comparison of plasma metabolism and sample stabilization for quantitative bioanalyses: application to (R)-CE3F4 in preclinical development, including metabolite identification by high-resolution mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2021.122943 ◽

2021 ◽

pp. 122943

Author(s):

Balthazar Toussaint ◽

Hervé Hillaireau ◽

Emmanuel Jaccoulet ◽

Catherine Cailleau ◽

Pauline Legrand ◽

...

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

High Resolution Mass Spectrometry ◽

Metabolite Identification ◽

Preclinical Development ◽

Interspecies Comparison ◽

High Resolution Mass ◽

Resolution Mass

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4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry

Forensic Toxicology ◽

10.1007/s11419-015-0287-4 ◽

2015 ◽

Vol 34 (1) ◽

pp. 61-75 ◽

Cited By ~ 29

Author(s):

Kayla N. Ellefsen ◽

Ariane Wohlfarth ◽

Madeleine J. Swortwood ◽

Xingxing Diao ◽

Marta Concheiro ◽

...

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

In Silico ◽

High Resolution Mass Spectrometry ◽

Metabolite Identification ◽

Human Hepatocyte ◽

Metabolic Stability ◽

In Silico Prediction ◽

High Resolution Mass ◽

Resolution Mass

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Metabolite identification and profile of endosulfan sulfate in three human liver preparations using liquid chromatography-high resolution mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2020.121996 ◽

2020 ◽

Vol 1140 ◽

pp. 121996

Author(s):

Hwa-Kyung Lee ◽

Tae Yeon Kong ◽

Won-Gu Choi ◽

Ju-Hyun Kim ◽

Yongho Shin ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Human Liver ◽

High Resolution Mass Spectrometry ◽

Metabolite Identification ◽

Endosulfan Sulfate ◽

High Resolution Mass ◽

Resolution Mass

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compMS2Miner: An Automatable Metabolite Identification, Visualization, and Data-Sharing R Package for High-Resolution LC–MS Data Sets

Analytical Chemistry ◽

10.1021/acs.analchem.6b02394 ◽

2017 ◽

Vol 89 (7) ◽

pp. 3919-3928 ◽

Cited By ~ 14

Author(s):

William M. B. Edmands ◽

Lauren Petrick ◽

Dinesh K. Barupal ◽

Augustin Scalbert ◽

Mark J. Wilson ◽

...

Keyword(s):

High Resolution ◽

Data Sharing ◽

Metabolite Identification ◽

R Package ◽

Data Sets

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