Low-dose enteric-coated aspirin does not inhibit thromboxane B2 and prostaglandin E2: data-derived hypothesis formulation

2012 ◽  
Vol 2 (7) ◽  
pp. 747-752 ◽  
Author(s):  
Charles H Hennekens ◽  
Scott Hetzel ◽  
Michael Pfeffer ◽  
Ricky Schneider ◽  
Steven Borzak ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Low Dose ◽  
Thromboxane B2 ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target

Blood ◽  
2012 ◽  
Vol 119 (15) ◽  
pp. 3595-3603 ◽  
Author(s):  
Silvia Pascale ◽  
Giovanna Petrucci ◽  
Alfredo Dragani ◽  
Aida Habib ◽  
Francesco Zaccardi ◽  
...  
Keyword(s):  
Platelet Count ◽  
Essential Thrombocythemia ◽  
Low Dose ◽  
Once Daily ◽  
Dosing Interval ◽  
Aspirin Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Abstract Essential thrombocythemia (ET) is characterized by enhanced platelet generation and thrombotic complications. Once-daily low-dose aspirin incompletely inhibits platelet thromboxane A2 (TXA2) in the majority of ET patients. In the present study, we investigated the determinants of aspirin-insensitive platelet TXA2 biosynthesis and whether it could be further suppressed by changing the aspirin dose, formulation, or dosing interval. In 41 aspirin-treated ET patients, the immature platelet count predicted serum TXB2 independently of platelet count, age, JAK-2 V617F mutation, or cytoreduction (β = 3.53, P = .001). Twenty-one aspirin-treated patients with serum TXB2 ≥ 4 ng/mL at 24 hours after dosing were randomized to the following 7-day regimens in a crossover design: enteric-coated aspirin 100 mg twice daily, enteric-coated aspirin 200 mg once daily, or plain aspirin 100 mg once daily. A twice-daily regimen caused a further 88% median (IQR, 78%-92%, P < .001) TXB2 reduction and normalized the functional platelet response to aspirin, as assessed by urinary 11-dehydro-TXB2 excretion and the VerifyNow Aspirin assay. Doubling the aspirin dose reduced serum TXB2 only partially by 39% median (IQR, 29%-54%, P < .05). We conclude that the abnormal megakaryopoiesis characterizing ET accounts for a shorter-lasting antiplatelet effect of low-dose aspirin through faster renewal of platelet cyclooxygenase-1, and impaired platelet inhibition can be rescued by modulating the aspirin dosing interval rather than the dose.

Relationship between continuous use of low-dose enteric-coated aspirin and gastrointestinal injuries in patients with gastrointestinal hemorrhage

2013 ◽  
Vol 24 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Mirhadi MOUSAVI ◽  
Babak SALEHIMARZIJARANI ◽  
Zohreh DADVAR ◽  
Niloufar Yahyapour JALALY ◽  
Neda VALIZADEH ◽  
...  
Keyword(s):  
Gastrointestinal Hemorrhage ◽  
Low Dose ◽  
Enteric Coated Aspirin ◽  
Enteric Coated ◽  
Continuous Use

Lack of Bioequivalence Among Low-dose, Enteric-coated Aspirin Preparations

2017 ◽  
Vol 103 (6) ◽  
pp. 1047-1051 ◽  
Author(s):  
Dermot Cox ◽  
Desmond J. Fitzgerald
Keyword(s):  
Low Dose ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Small Bowel Injury by Low-Dose Enteric-Coated Aspirin and Treatment With Misoprostol: A Pilot Study

2008 ◽  
Vol 6 (11) ◽  
pp. 1279-1282 ◽  
Author(s):  
Toshio Watanabe ◽  
Satoshi Sugimori ◽  
Natsuhiko Kameda ◽  
Hirohisa Machida ◽  
Hirotoshi Okazaki ◽  
...  
Keyword(s):  
Pilot Study ◽  
Small Bowel ◽  
Low Dose ◽  
Bowel Injury ◽  
Small Bowel Injury ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Low‐dose enteric‐coated aspirin as an antiplatelet preparation

1988 ◽  
Vol 148 (4) ◽  
pp. 207 ◽  
Author(s):  
L.J. McLeod ◽  
M.S. Roberts ◽  
P.R. Seville
Keyword(s):  
Low Dose ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Comparison of Incident Dyspepsia Between Low-Dose Plain Aspirin and Enteric-Coated Aspirin

2010 ◽  
Vol 8 (4) ◽  
pp. 395 ◽  
Author(s):  
Martijn G.H. van Oijen ◽  
Jeroen Jaspers Focks ◽  
Robert J.F. Laheij
Keyword(s):  
Low Dose ◽  
Enteric Coated Aspirin ◽  
Enteric Coated

Cumulative antiplatelet effect of low-dose enteric coated aspirin

1985 ◽  
Vol 60 (4) ◽  
pp. 635-642 ◽  
Author(s):  
Joseph A. Jakubowski ◽  
Meir J. Stampfer ◽  
Raymond V aillancourt ◽  
Daniel Deykin
Keyword(s):  
Low Dose ◽  
Antiplatelet Effect ◽  
Enteric Coated Aspirin ◽  
Enteric Coated
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