Emerging therapies for head and neck cancer: review of the Phase II and III trials

2011 ◽  
Vol 1 (5) ◽  
pp. 669-687
Author(s):  
Nicole G Chau ◽  
Bonnie S Glisson
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Cancer Review ◽  
Emerging Therapies ◽  
Phase Ii And Iii

A phase II study of docetaxel and carboplatin with concurrent radiation therapy for locally advanced head and neck cancer

2011 ◽  
Vol 38 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Imjai Chitapanarux ◽  
Vicharn Lorvidhaya ◽  
Ekasit Tharavichitkul ◽  
Somvilai Mayurasakorn ◽  
Pichit Sittitrai ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Study ◽  
Locally Advanced ◽  
Advanced Head

scholarly journals A phase II study of piritrexim in patients with advanced squamous head and neck cancer

Cancer ◽  
1992 ◽  
Vol 69 (4) ◽  
pp. 1008-1011 ◽  
Author(s):  
Wu-Ching Uen ◽  
Andrew T. Huang ◽  
Robert Mennel ◽  
Stephen E. Jones ◽  
Monica B. Spaulding ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Study

scholarly journals Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2)

2018 ◽  
Vol 49 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Takashi Matsuzuka ◽  
Naomi Kiyota ◽  
Junki Mizusawa ◽  
Tetsuo Akimoto ◽  
Masato Fujii ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Trial ◽  
Locally Advanced ◽  
Clinical Impact ◽  
Advanced Head

A Phase II Study of AMSA in Head and Neck Cancer

1987 ◽  
Vol 10 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Diana Crivellari ◽  
Umberto Tirelli ◽  
Sergio Frustaci ◽  
Andrea Veronesi ◽  
Enzo Galligioni ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Study

scholarly journals Evaluation of Nimotuzumab for the treatment of head and neck cancer: Meta-analysis of controlled trials

Bionatura ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 1056-1062
Author(s):  
Carmen Viada ◽  
Aliz M. Vega ◽  
Mayte Robaina ◽  
Aliuska Frías ◽  
Mabel Álvarez ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Sensitivity Analysis ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Sufficient Evidence ◽  
Forest Plot ◽  
Controlled Trials

Nimotuzumab, humanized monoclonal antibody, directed against the epidermal growth factor receptor: highly expressed protein in malignant tumors of epithelial origin. It has been registered for head and neck tumors since 2002. To determine the effectiveness of Nimotuzumab in head and neck cancer through the combined meta-analysis technique. A search was conducted in PubMed, in an indexed magazine with the words “Nimotuzumab”, “head and neck,” 48 articles published by Cuban and foreign authors were detected between April 1, 2005, and July 31, 2019, in which the results of clinical studies conducted with the monoclonal antibody Nimotuzumab are described. Seven clinical trials conducted in Cuba from 2005-2019 with Nimotuzumab are described; three Phase I / II (with 14, 10 and 10 patients respectively), a Phase II / III with 106 patients, a Phase II with 37 patients, two Phase IV (with 386 and 225 patients each) and a study promoted by the Researcher with 17 patients. From these studies, the three controlled trials were selected by the PRISMA flow chart. The meta-analysis consisted of the construction of the Forest Plot graph, the sensitivity analysis and the cumulative analysis. The meta-analysis shows favorable results for Nimotuzumab, without heterogeneity (I2 = 0%). The sensitivity analysis reveals that the test that differs most from the others is Phase II / III. The cumulative analysis indicates that after the second trial, there is already sufficient evidence.

Phase II study of etoposide (VP-16) in the treatment of advanced head and neck cancer

1985 ◽  
Vol 8 (5) ◽  
pp. 393-395 ◽  
Author(s):  
Steven M. Grunberg ◽  
Ira E. Felman ◽  
Kirit V. Gala ◽  
Kay B. Johnson ◽  
Jay C. Owens
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Ii ◽  
Neck Cancer ◽  
Phase Ii Study ◽  
Advanced Head
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