Dried blood spot analysis for rat and dog studies: validation, hematocrit, toxicokinetics and incurred sample reanalysis

Bioanalysis ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 869-883 ◽  
Author(s):  
Enaksha Wickremsinhe
Keyword(s):  
Dried Blood Spot ◽  
Incurred Sample Reanalysis ◽  
Blood Spot ◽  
Spot Analysis

Validation and clinical application of dried blood spot assay for quantitative assessment of edoxaban in healthy adults

Bioanalysis ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 393-407
Author(s):  
Ling He ◽  
Roohi Gajee ◽  
Raj Mangaraj ◽  
Michael P Waldron ◽  
Karen S Brown
Keyword(s):  
Healthy Subjects ◽  
Quantitative Assessment ◽  
Dried Blood Spot ◽  
Plasma Samples ◽  
Open Label ◽  
Finger Prick ◽  
Incurred Sample Reanalysis ◽  
Alternative Methodology ◽  
Blood Spot ◽  
Sampling Approach

Aim: Dried blood spot (DBS) is a sampling approach that offers several advantages over plasma and whole blood (WB) sampling, but several factors, such as hematocrit and temperature, can adversely affect quantitation. Methodology & results: In an open-label, three-way crossover study in healthy subjects, we explored the correlation between DBS, WB and plasma samples, and between DBS samples from finger-prick and venipuncture blood for measuring edoxaban and its metabolite M-4 using LC–MS/MS. The methods were validated comprehensively. The incurred sample reanalysis experiments demonstrated quantitation reproducibility in all three matrices. Overall, there was a good correlation (near perfect concordance for edoxaban) among plasma, WB and DBS measurements. M-4 concentrations in DBS and WB were lower than in plasma. Conclusion: These results indicate using DBS may be used as an alternative methodology to measure edoxaban pharmacokinetics.

Derivatization Techniques in Dried Blood Spot Analysis

2014 ◽  
pp. 344-354
Author(s):  
Ann-Sofie M.E. Ingels ◽  
Nele Sadones ◽  
Pieter M.M. De Kesel ◽  
Willy E. Lambert ◽  
Christophe P. Stove
Keyword(s):  
Dried Blood Spot ◽  
Blood Spot ◽  
Spot Analysis

What is the right blood hematocrit preparation procedure for standards and quality control samples for dried blood spot analysis?

Bioanalysis ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 345-351 ◽  
Author(s):  
Remco A Koster ◽  
Jan-Willem C Alffenaar ◽  
Rixt Botma ◽  
Ben Greijdanus ◽  
Daan J Touw ◽  
...  
Keyword(s):  
Quality Control ◽  
Dried Blood Spot ◽  
Preparation Procedure ◽  
The Right ◽  
Blood Spot ◽  
Control Samples ◽  
Spot Analysis

Alginate and Chitosan Foam Combined with Electromembrane Extraction for Dried Blood Spot Analysis

2012 ◽  
Vol 84 (20) ◽  
pp. 8783-8789 ◽  
Author(s):  
Lars Erik Eng Eibak ◽  
Anne Bee Hegge ◽  
Knut Einar Rasmussen ◽  
Stig Pedersen-Bjergaard ◽  
Astrid Gjelstad
Keyword(s):  
Dried Blood Spot ◽  
Electromembrane Extraction ◽  
Blood Spot ◽  
Spot Analysis

Accuracy of Dried Blood Spot Analysis for Measurement of Plasma Glucose Concentrations in the Hypoglycaemic Range

1996 ◽  
Vol 91 (s35) ◽  
pp. 14P-14P
Author(s):  
DR Parker ◽  
A Bargiotta ◽  
FJ Cowan ◽  
Rjm Corrall
Keyword(s):  
Plasma Glucose ◽  
Dried Blood Spot ◽  
Blood Spot ◽  
Spot Analysis

Dried Blood Spot Analysis – the next level of therapeutic drug monitoring?

2014 ◽  
Vol 47 (06) ◽  
Author(s):  
M Scherf-Clavel ◽  
M Hohner ◽  
S Unterecker ◽  
P Högger
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Dried Blood Spot ◽  
Therapeutic Drug ◽  
Blood Spot ◽  
Spot Analysis
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