Metabolomics pilot study to identify volatile organic compound markers of childhood asthma in exhaled breath

Bioanalysis ◽  
2013 ◽  
Vol 5 (18) ◽  
pp. 2239-2247 ◽  
Author(s):  
Florian Gahleitner ◽  
Cristina Guallar-Hoyas ◽  
Caroline S Beardsmore ◽  
Hitesh C Pandya ◽  
CL Paul Thomas
Keyword(s):  
Pilot Study ◽  
Organic Compound ◽  
Volatile Organic Compound ◽  
Childhood Asthma ◽  
Exhaled Breath ◽  
Volatile Organic

scholarly journals Breathomics—exhaled volatile organic compound analysis to detect hepatic encephalopathy: a pilot study

2016 ◽  
Vol 10 (1) ◽  
pp. 016012 ◽  
Author(s):  
R P Arasaradnam ◽  
M McFarlane ◽  
K Ling ◽  
S Wurie ◽  
N O’Connell ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Pilot Study ◽  
Organic Compound ◽  
Volatile Organic Compound ◽  
Volatile Organic

scholarly journals Application of Fecal Volatile Organic Compound Analysis in Clinical Practice: Current State and Future Perspectives

Chemosensors ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 29 ◽  
Author(s):  
Sofia el Manouni el Hassani ◽  
Daniel Berkhout ◽  
Sofie Bosch ◽  
Marc Benninga ◽  
Nanne de Boer ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Clinical Practice ◽  
Organic Compound ◽  
Volatile Organic Compound ◽  
Exhaled Breath ◽  
Diagnostic Biomarker ◽  
Detection Techniques ◽  
Wide Range ◽  
Volatile Organic ◽  
Selected Ion Flow Tube

Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as non-invasive diagnostic biomarker in clinical medical practice. The spectrum of VOCs, originating from (patho)physiological metabolic processes in the human body and detectable in bodily excrements, such as exhaled breath, urine and feces, harbors a magnificent source of information. Thus far, the majority of studies have focused on VOC analysis in exhaled breath, aiming at identification of disease-specific VOC profiles. Recently, an increasing number of studies have evaluated the usability of VOC present in the headspace of feces in the diagnostic work-up of a wide range of gastrointestinal diseases. Promising results have been demonstrated particularly in those diseases in which microbiota alterations are considered to play a significant etiological role, such as colorectal carcinoma, inflammatory bowel disease, irritable bowel syndrome, celiac disease and infectious bowel diseases. In addition, fecal VOC analysis seems to have potential as a diagnostic biomarker for extra-intestinal diseases, including bronchopulmonary dysplasia and sepsis. Different methods for VOC analysis have been used in medical studies, such as gas-chromatography mass spectrometry, selected-ion flow tube-mass spectrometry, ion-mobility spectrometry, and electronic nose devices. In this review, the available literature on the potential of fecal VOCs as diagnostic biomarker, including an overview of relevant VOC detection techniques, is discussed. In addition, future hurdles, which need to be taken prior to implementation of VOC analysis in daily clinical practice, are outlined.

scholarly journals PTU-163 Urinary Volatile Organic Compound Analysis To Distinguish Coeliac Disease From Irritable Bowel Syndrome: A Pilot Study

Gut ◽  
2014 ◽  
Vol 63 (Suppl 1) ◽  
pp. A110.1-A110
Author(s):  
J Covington ◽  
M McFarlane ◽  
R Harbord ◽  
E Westenbrink ◽  
S Chambers ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Organic Compound ◽  
Coeliac Disease ◽  
Volatile Organic Compound ◽  
Volatile Organic ◽  
Irritable Bowel

scholarly journals Limited clinical value of exhaled volatile organic compound measurements in childhood asthma

2018 ◽  
Vol 4 (4) ◽  
pp. 00026-2018 ◽  
Author(s):  
Maria G. Fuglsbjerg ◽  
Morten A. Rasmussen ◽  
Kirsten S. Hansen ◽  
Agnieszka Smolinska ◽  
Jan W. Dallinga ◽  
...  
Keyword(s):  
Organic Compound ◽  
Volatile Organic Compound ◽  
Childhood Asthma ◽  
Clinical Value ◽  
Volatile Organic

scholarly journals Differentiating Coeliac Disease from Irritable Bowel Syndrome by Urinary Volatile Organic Compound Analysis – A Pilot Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e107312 ◽  
Author(s):  
Ramesh P. Arasaradnam ◽  
Eric Westenbrink ◽  
Michael J. McFarlane ◽  
Ruth Harbord ◽  
Samantha Chambers ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Organic Compound ◽  
Coeliac Disease ◽  
Volatile Organic Compound ◽  
Volatile Organic ◽  
Irritable Bowel
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