scholarly journals Combination of LINE-1 hypomethylation and RASSF1A promoter hypermethylation in serum DNA is a non-invasion prognostic biomarker for early recurrence of hepatocellular carcinoma after curative resection

Neoplasma ◽  
2017 ◽  
Vol 64 (05) ◽  
pp. 795-802 ◽  
Author(s):  
Z. J. Liu ◽  
Y. Huang ◽  
L. Wei ◽  
J. Y. He ◽  
Q. Y. Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Prognostic Biomarker ◽  
Promoter Hypermethylation ◽  
Early Recurrence ◽  
Serum Dna

A long non-coding RNA-based signature predicts early recurrence in hepatocellular carcinoma

2021 ◽  
pp. 1-10
Author(s):  
Shuai He ◽  
Jin-Feng Li ◽  
Hao Tian ◽  
Ye Sang ◽  
Xiao-Jing Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Risk Model ◽  
Cox Regression ◽  
Early Recurrence ◽  
Support Vector ◽  
Term Survival ◽  
Cox Regression Analysis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

BACKGROUND: Early recurrence is the main obstacle for long-term survival of hepatocellular carcinoma (HCC) patients after curative resection. OBJECTIVE: We aimed to develop a long non-coding RNA (lncRNA) based signature to predict early recurrence. METHODS: Using bioinformatics analysis and quantitative reverse transcription PCR (RT-qPCR), we screened for lncRNA candidates that were abnormally expressed in HCC. The expression levels of candidate lncRNAs were analyzed in HCC tissues from 160 patients who underwent curative resection, and a risk model for the prediction of recurrence within 1 year (early recurrence) of HCCs was constructed with linear support vector machine (SVM). RESULTS: A lncRNA-based classifier (Clnc), which contained nine differentially expressed lncRNAs including AF339810, AK026286, BC020899, HEIH, HULC, MALAT1, PVT1, uc003fpg, and ZFAS1 was constructed. In the test set, this classifier reliably predicted early recurrence (AUC, 0.675; sensitivity, 72.0%; specificity, 63.1%) with an odds ratio of 4.390 (95% CI, 2.120–9.090). Clnc showed higher accuracy than traditional clinical features, including tumor size, portal vein tumor thrombus (PVTT) in predicting early recurrence (AUC, 0.675 vs 0.523 vs 0.541), and had much higher sensitivity than Barcelona Clinical Liver Cancer (BCLC; 72.0% vs 50.0%), albeit their AUCs were comparable (0.675 vs 0.678). Moreover, combining Clnc with BCLC significantly increased the AUC, compared with Clnc or BCLC alone in predicting early recurrence (all P< 0.05). Finally, logistic and Cox regression analysis suggested that Clnc was an independent prognostic factor and associated with the early recurrence and recurrence-free survival of HCC patients after resection, respectively (all P= 0.001). CONCLUSIONS: Our lncRNA-based classifier Clnc can predict early recurrence of patients undergoing surgical resection of HCC.

scholarly journals α-Methylacyl-CoA racemase (AMACR) serves as a prognostic biomarker for the early recurrence/metastasis of HCC

2014 ◽  
Vol 67 (11) ◽  
pp. 974-979 ◽  
Author(s):  
Bo Xu ◽  
Zhixiong Cai ◽  
Yongyi Zeng ◽  
Lihong Chen ◽  
Xiaobo Du ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Study ◽  
Quantitative Proteomics ◽  
Large Scale ◽  
Prognostic Biomarker ◽  
Early Recurrence ◽  
Clinical Parameter ◽  
Regional Lymph Nodes ◽  
High Expression Group ◽  
Low Expression

AimsHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it is still lacking effective prognostic biomarkers so far. Previous results of the iTRAQ-based quantitative proteomics study (iTRAQ-2DLC-MS/MS) have shown that α-methylacyl-CoA racemase (AMACR) might be a promising prognostic biomarker for the early recurrence/metastasis of hepatocellular carcinoma (HCC). Here a large-scale cohort clinical study was performed to evaluate its prognostic potential.MethodsHCC samples from patients (n=158) were used for the construction of tissue microarray. The expression level of AMACR was determined by immunohistochemical staining. A large-scale cohort clinical study between the expression of AMACR and some major clinical parameter has been performed to assess the prognostic potential of AMACR for the early recurrence/metastasis of HCC.ResultsSome important clinical parameters such as α-fetoprotein, tumour numbers, dissemination to regional lymph nodes, tumour capsule and portal vein tumour thrombosis are significantly associated with the low expression of AMACR. The expression of AMACR was an independent factor for the survival of patients with HCC. The median survival time was 17 months in the low-expression group compared with 45 months in the high-expression group.ConclusionsThis study reveals that the AMACR might be a potential prognostic marker for predicting early recurrence/metastasis of HCC after hepatectomy.

scholarly journals Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection

2014 ◽  
Vol 35 (10) ◽  
pp. 2283-2290 ◽  
Author(s):  
Xiuchao Wang ◽  
He Ren ◽  
Tiansuo Zhao ◽  
Jing Chen ◽  
Wei Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Stem Cell Factor ◽  
Curative Resection ◽  
Prognostic Biomarker

Risk Factors for Early Recurrence of Single Lesion Hepatocellular Carcinoma After Curative Resection

2016 ◽  
Vol 40 (10) ◽  
pp. 2466-2471 ◽  
Author(s):  
Mitsugi Shimoda ◽  
Kazuma Tago ◽  
Takayuki Shiraki ◽  
Shozo Mori ◽  
Masato Kato ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Early Recurrence ◽  
Single Lesion

scholarly journals Factors influencing early recurrence of hepatocellular carcinoma after curative resection

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094555
Author(s):  
Yu Zhu ◽  
Lingling Gu ◽  
Ting Chen ◽  
Guoqun Zheng ◽  
Chao Ye ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Cox Regression ◽  
Postoperative Recurrence ◽  
Early Recurrence ◽  
Tumor Diameter ◽  
Cox Regression Analysis ◽  
Factors Influencing ◽  
Linear Manner ◽  
Hcc Recurrence

Objective To identify the factors influencing early recurrence in patients with hepatocellular carcinoma (HCC) after curative resection. Methods Clinical data for 99 patients with HCC undergoing curative resection were analyzed. The clinicopathological factors influencing early recurrence were analyzed by Cox regression. Results Twenty-five of 99 patients (25.3%) suffered from early recurrence. There were significant differences between patients with and without recurrence in terms of tumor diameter, tumor capsular integrity, and preoperative alpha fetoprotein level. Cox regression analysis revealed that a tumor diameter >2.6 cm and preoperatively increased total bilirubin (TBL) level were risk factors for postoperative recurrence, while tumor capsular integrity had a protective effect on postoperative recurrence. After adjusting for preoperative TBL level and tumor capsular integrity, the risk of HCC recurrence was markedly increased in line with increasing tumor diameter in a non-linear manner. Conclusion Tumor diameter >2.6 cm and preoperatively increased TBL level are associated with a higher risk of early recurrence after curative resection in patients with HCC, while tumor capsular integrity is associated with a lower risk of early recurrence.

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