scholarly journals Cell-cycle arrest at G2/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines

Neoplasma ◽  
2014 ◽  
Vol 60 (06) ◽  
pp. 620-626 ◽  
Author(s):  
X. Cheng ◽  
D. Zhou ◽  
J. Wei ◽  
J. Lin
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Proliferation Inhibition ◽  
Human Colorectal Cancer ◽  
Mitofusin 2 ◽  
Cycle Arrest ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines

scholarly journals Scorpion (Androctonus bicolor) venom exhibits cytotoxicity and induces cell cycle arrest and apoptosis in breast and colorectal cancer cell lines

2016 ◽  
Vol 48 (5) ◽  
pp. 537 ◽  
Author(s):  
AbdulrahmanK Al-Asmari ◽  
Anvarbatcha Riyasdeen ◽  
Rajamohamed Abbasmanthiri ◽  
Mohammed Arshaduddin ◽  
FahadAli Al-Harthi
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Colorectal Cancer Cell ◽  
Cycle Arrest ◽  
Colorectal Cancer Cell Lines

scholarly journals Expressions of Cell Cycle Regulators in Human Colorectal Cancer Cell Lines

1997 ◽  
Vol 88 (9) ◽  
pp. 855-860 ◽  
Author(s):  
Osamu Tominaga ◽  
Marcelo Eidi Nita ◽  
Hirokazu Nagawa ◽  
Shin Fujii ◽  
Takashi Tsuruo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Colorectal Cancer Cell ◽  
Cell Cycle Regulators ◽  
Human Colorectal Cancer ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Lines

Action of a library of O-glycosylation inhibitors on the growth of human colorectal cancer cells in culture

2005 ◽  
Vol 33 (4) ◽  
pp. 721-723 ◽  
Author(s):  
G. Patsos ◽  
V. Hebbe-Viton ◽  
R. San Martin ◽  
C. Paraskeva ◽  
T. Gallagher ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Growth Patterns ◽  
Limited Information ◽  
Human Colorectal Cancer ◽  
Human Colorectal Cancer Cell ◽  
Colorectal Cancer Cells ◽  
Colorectal Cancer Cell Lines

O-glycosylation is thought to play a significant role in the regulation of cell growth. However, only limited information is available, and few specific and selective inhibitors have been found. We have synthesized a library of O-glycosylation inhibitors based on benzyl-O-N-acetyl-D-galactosamine. These inhibitors were tested with an established series of human colorectal cancer cell lines, which model the adenoma-carcinoma sequence. Cancer cells were incubated with the inhibitors, and examined for cell growth patterns, and cellular and subcellular glycosylation using a range of lectins with confocal microscopy. The specificity of O-glycan inhibition was confirmed for the library, relative to other forms of glycosylation. All inhibitors tested resulted in smaller cell yields. However, a differential effect on O-glycosylation was detected using the lectins showing variation of localization at a subcellular level in the various cell lines. Further differential action of the inhibitor library was observed for apoptosis and on the cell cycle with the cell lines tested. This work demonstrates that O-glycosylation is closely involved in the regulation of cell growth in colorectal cancer cells and that the generation of a library of low-molecular-mass inhibitors offers a valuable means of examining this regulation at the molecular level.

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