scholarly journals Hepatoprotective effect of gallic acid against type 2-induced diabetic liver injury in male rats through modulation of fetuin-A and GLP-1 with involvement of ERK1/2/NF-κB and Wnt1/β-catenin signaling pathways

2021 ◽  
Vol 40 (03) ◽  
pp. 221-234
Author(s):  
Shaimaa M. Bashar ◽  
Mona G. Elhadidy ◽  
Abeer F. Mostafa ◽  
Basma Hamed ◽  
Soheir Helmy ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathways ◽  
Gallic Acid ◽  
Hepatoprotective Effect ◽  
Male Rats ◽  
Fetuin A

scholarly journals Veratrilla baillonii Franch exerts anti-diabetic activity and improves liver injury through IRS/PI3K/AKT signaling pathways in type 2 diabetic db/db mice

2020 ◽  
Vol 75 ◽  
pp. 104204
Author(s):  
Cai-Jing He ◽  
Li-Qun Ma ◽  
Muhammad Sarfaraz Iqbal ◽  
Xian-Ju Huang ◽  
Jun Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathways ◽  
Akt Signaling ◽  
Type 2 Diabetic

scholarly journals Hepatoprotective Effect of Melatonin in Toxic Liver Injury in Rats

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 304 ◽  
Author(s):  
Oleshchuk ◽  
Ivankiv ◽  
Falfushynska ◽  
Mudra ◽  
Lisnychuk
Keyword(s):  
Liver Injury ◽  
Hepatoprotective Effect ◽  
Male Rats ◽  
Saline Control ◽  
Control Group ◽  
Radical Scavenger ◽  
Thiobarbituric Acid Reactive Substance ◽  
Lipid Hydroperoxides ◽  
Significant Difference ◽  
Toxic Liver Injury

Background and objectives: toxic liver injury results in nitrooxidative stress. Melatonin is a potent free radical scavenger, an inducible nitric oxide synthase (iNOS) inhibitor and an activator of antioxidant enzymes. The aim of this study was to investigate the hepatoprotective effect of exogenous melatonin on animals with acute toxic hepatitis. Material and methods: 36 healthy Sprague-Dawley male rats were split into three equal groups and given carbon tetrachloride (CCl4), 2 g/kg (CCl4 group) or the same dose of CCl4 and melatonin, 10 mg/kg (CCl4/melatonin group) or saline (control group). The effect of melatonin on prooxidant and antioxidant system indexes, NO and NOS levels in serum and liver, data of mitochondrial chain functions and cytolysis in liver were evaluated in all three groups. Results: melatonin significantly decreased activities of AST, ALT, ceruloplasmine and thiobarbituric acid reactive substance (TBARS) in serum. Catalase activity was lowered in serum but not in the liver. Hepatic TBARS, lipid hydroperoxides and glutathione concentrations were decreased, while superoxide dismutase, mitochondrial cytochrome oxidase and succinate dehydrogenase activities increased. Melatonin inhibited synthesis of stable NO metabolites in serum: NO2-by 37.9%; NO3-by 29.2%. There was no significant difference in content NO2-in the liver, but concentration of NO3-increased by 32.6%. Melatonin significantly reduced iNOS concentrations both in serum (59.7%) and liver (57.8%) but did not affect endothelial isoform enzyme activities neither in serum, nor in liver. The histopathological liver lesions observed in the CCl4/melatonin group were less severe than those seen in the CCl4 group. Conclusions: we demonstrated an ameliorating effect of melatonin on prooxidants and antioxidants, NO-NOS systems balance, mitochondrial function and histopathological lesions in the liver in rats with CCl4-induced hepatitis.

Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways

2020 ◽  
Vol 874 ◽  
pp. 173010
Author(s):  
Nesma M.E. Abo El- Nasr ◽  
Dalia Osama Saleh ◽  
Sawsan S. Mahmoud ◽  
Salwa M. Nofal ◽  
Rania M. Abdelsalam ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Liver Injury ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Ras Signaling

scholarly journals L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia

2021 ◽  
pp. 1-11
Author(s):  
Ayobami Dare ◽  
Mahendra L. Channa ◽  
Anand Nadar
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Liver Injury ◽  
Diabetic Rats ◽  
Sirtuin 1 ◽  
Male Rats ◽  
Histopathological Analysis ◽  
Nuclear Factor ◽  
Therapeutic Benefits

Type-2 diabetes (T2D) is associated with liver toxicity. L-ergothioneine (L-egt) has been reported to reduce toxicity in tissues exposed to injury, while metformin is commonly prescribed to manage T2D. Hence, this study evaluates the hepatoprotective role of L-egt, with or without metformin, in T2D male rats. A total of 36 adult male Sprague–Dawley rats were randomly divided into non-diabetic (n = 12) and diabetic (n = 24) groups. After induction of diabetes, animals were divided into six groups (n = 6) and treated orally either with deionized water, L-egt (35 mg/kg bodyweight (bwt)), metformin (500 mg/kg bwt), or a combination of L-egt and metformin for 7 weeks. Body weight and blood glucose were monitored during the experiment. Thereafter, animals were euthanized and liver tissue was excised for biochemical, ELISA, real-time quantitative PCR, and histopathological analysis. L-egt with or without metformin reduced liver hypertrophy, liver injury, triglycerides, oxidative stress, and inflammation. Also, L-egt normalized mRNA expression of SREBP-1c, fatty acid synthase, nuclear factor kappa B, transforming growth factor β1, nuclear factor erythroid 2–related factor 2, and sirtuin-1 in diabetic rats. Furthermore, co-administration of L-egt with metformin to diabetic rats reduced blood glucose and insulin resistance. These results provide support to the therapeutic benefits of L-egt in the management of liver complications associated with T2D.

scholarly journals Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-κB signaling pathways in type 2 diabetic rats

2021 ◽  
Vol 85 ◽  
pp. 104657
Author(s):  
Fuqiang Zhao ◽  
Kexue Zhu ◽  
Qiancheng Zhao ◽  
Qibing Liu ◽  
Jun Cao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathways ◽  
Diabetic Rats ◽  
Type 2 Diabetic
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