scholarly journals Selective hippocampal cell damage and mossy fiber sprouting induced by chronic intracerebral injections of 2-deoxy-D-glucose

2020 ◽  
Vol 39 (01) ◽  
pp. 99-106
Author(s):  
Evgeniia Samokhina ◽  
Anton Malkov ◽  
Alexander Samokhin ◽  
Irina Popova
Keyword(s):  
Mossy Fiber ◽  
Cell Damage ◽  
Mossy Fiber Sprouting ◽  
Hippocampal Cell

scholarly journals Correlations Between Granule Cell Dispersion, Mossy Fiber Sprouting, and Hippocampal Cell Loss in Temporal Lobe Epilepsy

Epilepsia ◽  
1999 ◽  
Vol 40 (10) ◽  
pp. 1393-1401 ◽  
Author(s):  
Bouchaib El Bahh ◽  
Veronique Lespinet ◽  
Dominique Lurton ◽  
Monique Coussemacq ◽  
Gildas Le Gal La Salle ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Mossy Fiber ◽  
Cell Loss ◽  
Mossy Fiber Sprouting ◽  
Hippocampal Cell ◽  
Cell Dispersion

Inhibition of Autophagy Potentiated Hippocampal Cell Death Induced by Endoplasmic Reticulum Stress and its Activation by Trehalose Failed to be Neuroprotective

2019 ◽  
Vol 16 (1) ◽  
pp. 3-11
Author(s):  
Luisa Halbe ◽  
Abdelhaq Rami
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Er Stress ◽  
Cell Damage ◽  
Protective Mechanism ◽  
Unfolded Proteins ◽  
Neuronal Viability ◽  
Hippocampal Cell ◽  
Trigger Cell Death ◽  
Autophagy Inhibition

Introduction: Endoplasmic reticulum (ER) stress induced the mobilization of two protein breakdown routes, the proteasomal- and autophagy-associated degradation. During ERassociated degradation, unfolded ER proteins are translocated to the cytosol where they are cleaved by the proteasome. When the accumulation of misfolded or unfolded proteins excels the ER capacity, autophagy can be activated in order to undertake the degradative machinery and to attenuate the ER stress. Autophagy is a mechanism by which macromolecules and defective organelles are included in autophagosomes and delivered to lysosomes for degradation and recycling of bioenergetics substrate. Materials and Methods: Autophagy upon ER stress serves initially as a protective mechanism, however when the stress is more pronounced the autophagic response will trigger cell death. Because autophagy could function as a double edged sword in cell viability, we examined the effects autophagy modulation on ER stress-induced cell death in HT22 murine hippocampal neuronal cells. We investigated the effects of both autophagy-inhibition by 3-methyladenine (3-MA) and autophagy-activation by trehalose on ER-stress induced damage in hippocampal HT22 neurons. We evaluated the expression of ER stress- and autophagy-sensors as well as the neuronal viability. Results and Conclusion: Based on our findings, we conclude that under ER-stress conditions, inhibition of autophagy exacerbates cell damage and induction of autophagy by trehalose failed to be neuroprotective.

Time course of mossy fiber sprouting following bilateral transection of the fimbria/fornix

Neuroreport ◽  
1997 ◽  
Vol 8 (9) ◽  
pp. 2299-2303 ◽  
Author(s):  
Darren K. Hannesson ◽  
Lisa L. Armitage ◽  
Paul Mohapel ◽  
Michael E. Corcoran
Keyword(s):  
Time Course ◽  
Mossy Fiber ◽  
Mossy Fiber Sprouting

Mossy fiber sprouting is dissociated from kindling of generalized seizures in the guinea-pig

Neuroreport ◽  
2000 ◽  
Vol 11 (13) ◽  
pp. 2897-2901 ◽  
Author(s):  
Paul Mohapel ◽  
Lisa L. Armitage ◽  
Trevor H. Gilbert ◽  
Darren K. Hannesson ◽  
G Campbell Teskey ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Mossy Fiber ◽  
Mossy Fiber Sprouting ◽  
Generalized Seizures

scholarly journals Regionally Localized Recurrent Excitation in the Dentate Gyrus of a Cortical Contusion Model of Posttraumatic Epilepsy

2010 ◽  
Vol 103 (3) ◽  
pp. 1490-1500 ◽  
Author(s):  
Robert F. Hunt ◽  
Stephen W. Scheff ◽  
Bret N. Smith
Keyword(s):  
Head Injury ◽  
Dentate Gyrus ◽  
Action Potentials ◽  
Granule Cells ◽  
Mossy Fiber ◽  
Granule Cell Layer ◽  
Mossy Fiber Sprouting ◽  
Posttraumatic Epilepsy ◽  
Dentate Granule Cells ◽  
Cortical Contusion

Posttraumatic epilepsy is a frequent consequence of brain trauma, but relatively little is known about how neuronal circuits are chronically altered after closed head injury. We examined whether local recurrent excitatory synaptic connections form between dentate granule cells in mice 8–12 wk after cortical contusion injury. Mice were monitored for behavioral seizures shortly after brain injury and ≤10 wk postinjury. Injury-induced seizures were observed in 15% of mice, and spontaneous seizures were observed weeks later in 40% of mice. Timm's staining revealed mossy fiber sprouting into the inner molecular layer of the dorsal dentate gyrus ipsilateral to the injury in 95% of mice but not contralateral to the injury or in uninjured controls. Whole cell patch-clamp recordings were made from granule cells in isolated hippocampal brain slices. Cells in slices with posttraumatic mossy fiber sprouting had an increased excitatory postsynaptic current (EPSC) frequency compared with cells in slices without sprouting from injured and control animals ( P < 0.001). When perfused with Mg2+-free artificial cerebrospinal fluid containing 100 μM picrotoxin, these cells had spontaneous bursts of EPSCs and action potentials. Focal glutamate photostimulation of the granule cell layer evoked a burst of EPSCs and action potentials indicative of recurrent excitatory connections in granule cells of slices with mossy fiber sprouting. In granule cells of slices without sprouting from injured animals and controls, spontaneous or photostimulation-evoked epileptiform activity was never observed. These results suggest that a new regionally localized excitatory network forms between dentate granule cells near the injury site within weeks after cortical contusion head injury.

Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining

Neuroreport ◽  
1996 ◽  
Vol 7 (5) ◽  
pp. 1029-1035 ◽  
Author(s):  
Gary W. Mathern ◽  
Joao P. Leite ◽  
Thomas L. Babb ◽  
James K. Pretorius ◽  
Paula A. Kuhlman ◽  
...  
Keyword(s):  
Mossy Fiber ◽  
Mossy Fiber Sprouting

A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats

Neuroscience ◽  
1999 ◽  
Vol 92 (1) ◽  
pp. 73-82 ◽  
Author(s):  
A.E Anderson ◽  
R.A Hrachovy ◽  
B.A Antalffy ◽  
D.L Armstrong ◽  
J.W Swann
Keyword(s):  
Tetanus Toxin ◽  
Mossy Fiber ◽  
Focal Epilepsy ◽  
Mossy Fiber Sprouting ◽  
Infant Rats
Sign in / Sign up

Export Citation Format

Share Document