scholarly journals Long non-coding RNA MT1JP exerts anti-cancer effects in breast cancer cells by regulating miR-92-3p

2020 ◽  
Vol 39 (01) ◽  
pp. 59-67
Author(s):  
Haiming Wu ◽  
Sa Li
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Non Coding Rna ◽  
Anti Cancer ◽  
Long Non Coding Rna

scholarly journals The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Haihua Wu ◽  
Yueyue Wang ◽  
Tiantian Chen ◽  
Yu Li ◽  
Haifeng Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Effects ◽  
Underlying Mechanism ◽  
Vital Role ◽  
Inflammatory Protein ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Anti Tumor Activity

Accumulating evidence demonstrates that long non-coding RNA (lncRNA) sprouty4-intron transcript 1 (lncRNA SPRY4-IT1) plays a vital role in the development of breast cancer. However, the underlying mechanism has not been eventually illuminated. We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast cancer cells and whether N-terminal polypeptide derived from viral macrophage inflammatory protein II (NT21MP) could exert its anti-tumor effect by regulating lncRNA SPRY4-IT1 and its target gene SKA2. Real-time RT-PCR, Western blotting, wound healing, and invasion assays were used to achieve this goal. We found that lncRNA SPRY4-IT1 was highly expressed in breast cancer cells. Moreover, NT21MP markedly inhibited biological effects of breast cancer cells by regulating lncRNA SPRY4-IT1, which was partially achieved through SKA2. Our findings suggested that lncRNA SPRY4-IT1 could serve as a novel biomarker by NT21MP for breast cancer.

MYC-driven regulation of long non-coding RNA profiles in breast cancer cells

Gene ◽  
2019 ◽  
Vol 714 ◽  
pp. 143955 ◽  
Author(s):  
Pervin Elvan Tokgun ◽  
Onur Tokgun ◽  
Serap Kurt ◽  
Ayse Gaye Tomatir ◽  
Hakan Akca
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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