scholarly journals Anti-oxidant and anti-inflamatuar effectiveness of caftaric acid on gastric ulcer induced by indomethacin in rats

2019 ◽  
Vol 38 (02) ◽  
pp. 175-181
Author(s):  
A. Tanyeli ◽  
F. Nur Ekinci ◽  
E. Eraslan ◽  
M. Can Güler ◽  
T. Nacar
Keyword(s):  
Gastric Ulcer ◽  
Caftaric Acid ◽  
Anti Oxidant

scholarly journals Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis

2021 ◽  
Vol 10 (2) ◽  
pp. 232-240
Author(s):  
Riham A. El-Shiekh ◽  
Abeer Salama ◽  
Asmaa K. Al-Mokaddem ◽  
Essam A. Abdel-Sattar
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
High Performance ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Cytotoxic Activities ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Anti Oxidant ◽  
Converting Enzyme Inhibition ◽  
Gross Examination

Introduction: Polysaccharides have numerous therapeutic values including immunity stimulation, angiotensin converting enzyme inhibition, wound healing, anti-diabetic and cytotoxic activities, in addition to their potent anti-oxidant properties. This work examined the gastroprotective and ulcer healing potential of mucilage fraction isolated from Solenostemma argel (Delile) Hayne (MFA) against ethanol-induced gastric ulcer in rats. Methods: Forty Sprague-Dawley rats were divided into five groups (n=8); normal control (I), ethanol control (II), 20 mg/kg Antodine pretreated rats (III), 100 mg/kg, and 200 mg/kg MFA pretreated rats, respectively (IV & V). All rats in groups II-V received single intragastric dose of ethanol (5 mL/kg) to induce gastric ulcer. Gastric mucosal injuries were assessed by stomach gross examination as well as histopathology, and immunohistochemistry of apoptotic markers. Also, several biochemical parameters including oxidative stress, proinflammatory cytokines, cytoprotective and cell proliferative biomarkers were measured. Results: High-performance liquid chromatography (HPLC) analysis of MFA revealed its composition of glucose, D-fucose and N-acetyl glucosamine as monosaccharaides, in addition to glucuronic and galacturonic acids. The data showed that MFA, 200 mg/kg had potent antioxidant, anti-inflammatory, cytoprotective, cell proliferative, and antiapoptotic activities which were better than Antodine. Conclusion: This study revealed that MFA had significant gastroprotective effects against ethanol-induced gastric injuries and could be a promising adjuvant therapy for ulcer treatment.

Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms

2016 ◽  
Vol 7 (1) ◽  
pp. 398-408 ◽  
Author(s):  
Paulrayer Antonisamy ◽  
Mariadhas Valan Arasu ◽  
Muniappan Dhanasekaran ◽  
Ki Choon Choi ◽  
Adithan Aravinthan ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protective Effects ◽  
Gastroprotective Activity ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

The gastroprotective activity of trigonelline against indomethacin-induced ulcer and the role of anti-oxidant, anti-inflammatory and anti-apoptotic mechanisms have been explored.

Efficacy of a chitosan-curcumin mixture in treating indomethacin-induced acute gastric ulcer in rats

2021 ◽  
Vol 22 ◽  
Author(s):  
Sineenat Kuadkaew ◽  
Suwipa Ungphaiboon ◽  
Narubodee Phdoongsombut ◽  
Sireewan Kaewsuwan ◽  
Sirima Mahattanadul
Keyword(s):  
Gastric Ulcer ◽  
Gastric Mucus ◽  
Ulcer Index ◽  
Antiulcer Agent ◽  
Alternative Agent ◽  
Anti Oxidant ◽  
Potential Alternative ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 1

Background: Curcumin is claimed as a potent protectant against gastric ulcer (GU) induced by strong necrotizing agents including NSAIDs through its antioxidant, anti-inflammatory and gastroprotective activities. However, it was found to exert opposite effects to either delay ulcer healing or exacerbate ulcer inflammation through some curative mechanisms differently modified by curcumin dosage. Its ability in inhibiting the expression of COX-2 may also delay the healing of NSAIDs-induced GU. Recently, a topical chitosan-curcumin solution has been found to be a safe and potential alternative agent in treating oral ulcer. Therefore, an oral chitosan-curcumin mixture was developed and determined for its efficacy in treating NSAIDs-induced GU in rat. Methods: A chitosan (150 mg)-curcumin (20 mg) mixture with optimal gastric pH was developed. Indomethacin (30 mg/kg) was given orally to the rat and test preparations were administered orally at 5 h later and then every 24 h for two consecutive days. The sum of all gastric ulcerated areas (mm2) for each stomach was used as ulcer index. Gastric pro-inflammatory mediators and cytoprotective factors were determined. Results: An oral administration of a chitosan-curcumin mixture exerted a superior efficacy than curcumin, chitosan or lansoprazole (a standard antiulcer agent) in healing indomethacin-induced GU. It was revealed that the mixture exhibited the highest anti-oxidant, anti-inflammatory and gastric mucus producing activities including the high potency in down-regulating pro-inflammatory COX-2 and iNOS expression but up-regulating cytoprotective COX-1, nNOS and eNOS expression. Conclusion: The present findings indicated the benefit of a chitosan-curcumin mixture as a potential alternative agent in treating NSAIDs-induced gastric ulcer.

scholarly journals Anti-ulcerogenic activity of dentatin from clausena excavata Burm.f. against ethanol-induced gastric ulcer in rats: Possible role of mucus and anti-oxidant effect

Phytomedicine ◽  
2019 ◽  
Vol 55 ◽  
pp. 31-39 ◽  
Author(s):  
Heyam Mohamed Ali Sidahmed ◽  
Jamuna Vadivelu ◽  
Mun Fai Loke ◽  
Ismail Adam Arbab ◽  
Bustamam Abdul ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Ulcerogenic Activity ◽  
Anti Oxidant ◽  
Oxidant Effect

scholarly journals Anti-Microbial, Anti-Oxidant and Anti-Ulcerogenic Effects of Shilajit on Gastric Ulcer in Rats

2012 ◽  
Vol 8 (1) ◽  
pp. 25-37 ◽  
Author(s):  
Mohamed-I. Kotb El-Sayed ◽  
Hatem-K. Amin ◽  
Ali-G. Al-Kaf
Keyword(s):  
Gastric Ulcer ◽  
Anti Oxidant

Mouse model of gastric infection with cytotoxin-expressing strain of Helicobacter pylori in studying of pathogenesis of chronic gastric ulcer

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S178-S184 ◽  
Author(s):  
PETER KONTUREK ◽  
TOMASZ BRZOZOWSKI ◽  
STANISLAW KONTUREK ◽  
ELZBIETA KARCZEWSKA ◽  
ROBERT PAJDO ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Mouse Model ◽  
Chronic Gastric Ulcer

The gastritis phenotype in gastric ulcer (GU) is not corpus predominant. Observations from the byk advanced gastric ulcer study (BAGUS) before and after eradication

2001 ◽  
Vol 120 (5) ◽  
pp. A251-A251
Author(s):  
P MALFERTHEINER ◽  
M KIST ◽  
T KIRCHNER ◽  
U PEITZ ◽  
M BOHUSCHKE ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Before And After

Gastric ulcer healing is regulated by platelets through endostatin release: Modulation by ticlopidine, aspirin and celecoxib

2001 ◽  
Vol 120 (5) ◽  
pp. A143-A143
Author(s):  
L MA ◽  
S ELLIOTT ◽  
G CIRINO ◽  
A BURET ◽  
J WALLACE
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Gastric Ulcer Healing
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