scholarly journals Hemodynamic properties and arterial structure in male rat offspring with fetal hypothyroidism

2016 ◽  
Vol 35 (04) ◽  
pp. 397-405 ◽  
Author(s):  
Mahboubeh Ghanbari ◽  
Fatemeh Bagheripuor ◽  
Abbas Piryaei ◽  
Saleh Zahediasl ◽  
Mahsa Noroozzadeh ◽  
...  
Keyword(s):  
Male Rat ◽  
Rat Offspring ◽  
Arterial Structure ◽  
Fetal Hypothyroidism

scholarly journals Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring

2014 ◽  
Vol 76 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Erin K. Zinkhan ◽  
Brook Y. Lang ◽  
Baifeng Yu ◽  
Yan Wang ◽  
Chengshe Jiang ◽  
...  
Keyword(s):  
Adult Male ◽  
Tobacco Smoke ◽  
Visceral Adiposity ◽  
Male Rat ◽  
Serum Corticosterone ◽  
Rat Offspring ◽  
Adult Male Rat

Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring

2021 ◽  
pp. 108751
Author(s):  
Rodrigo Moraga-Amaro ◽  
Raul Díaz-Galarce ◽  
Juan P. Donoso-Ramos ◽  
Valentina Ugalde ◽  
Sergio Linsambarth ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rat ◽  
Rat Offspring ◽  
Adult Male Rat

In utero exposure of high-dose di-n-butyl phthalate resulted in opposite effects on testicular cell apoptosis in late embryonic and pubertal male rat offspring

2017 ◽  
Vol 36 (12) ◽  
pp. 1236-1247 ◽  
Author(s):  
H Shen ◽  
K Liao ◽  
H-F Wu ◽  
H-C Lu ◽  
Y Li ◽  
...  
Keyword(s):  
Western Blot ◽  
Cell Apoptosis ◽  
In Utero ◽  
Male Rat ◽  
In Utero Exposure ◽  
High Dose ◽  
Testicular Cell ◽  
Rat Testis ◽  
Rat Offspring ◽  
Butyl Phthalate

Objective: To investigate the effects of in utero exposure to high-dose di- n-butyl phthalate (DBP) on testicular cell apoptosis in late embryonic and pubertal male rat offspring. Methods: Twenty pregnant Sprague-Dawley (SD) rats were divided into two groups. During gestation day (GD) 12 to GD 19, control group was given 1 ml day−1 of olive oil and experimental group was given DBP 500 mg kg−1 day−1 by gavage. On GD 19.5 and postnatal day (PND) 45, the testes were removed. Morphological analysis of the testes was observed by transmission electron microscopy and hematoxylin and eosin (H&E) staining. Testicular cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). The expression of Bcl-2, Bax, and p53 was presented by immunohistochemistry (IHC) and western blot. Data of the two groups was compared using independent samples t-test and Mann–Whitney test by SPSS 20.0. Results: H&E staining showed that spermatogenetic cells were significantly decreased in DBP exposed pubertal rat testis. The apoptosis index of testes in DBP-treated group was significantly lower on GD 19.5 but higher on PND 45 than that of the controls ( p < 0.01). IHC and western blot revealed significantly increased expression of Bcl-2 in GD 19.5 rat testis and Bax and p53 in PND 45 rat testis after DBP exposure, compared with the control ( p < 0.05). Conclusion: In utero exposure of high-dose DBP resulted in opposite effects on testicular cell apoptosis in late embryonic and pubertal rat offspring. The overexpression of Bcl-2, Bax, and p53 might be related to the occurrence of abnormal apoptosis and finally produce male infertility.

Developmental exposure to paracetamol causes anti-androgenic effects in male rat offspring

2010 ◽  
Vol 30 (2) ◽  
pp. 230-231 ◽  
Author(s):  
Ulla Hass ◽  
Pernille Rosenskjold Jacobsen ◽  
Julie Boberg ◽  
Sofie Christiansen ◽  
Christine Nellemann ◽  
...  
Keyword(s):  
Male Rat ◽  
Developmental Exposure ◽  
Rat Offspring

scholarly journals Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring

2016 ◽  
Vol 310 (5) ◽  
pp. R432-R439 ◽  
Author(s):  
C. A. Pileggi ◽  
S. A. Segovia ◽  
J. F. Markworth ◽  
C. Gray ◽  
X. D. Zhang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Muscle Development ◽  
Maternal Diet ◽  
Male Rat ◽  
Skeletal Muscle Development ◽  
High Fat ◽  
Rat Offspring ◽  
Total Fat

A high-saturated-fat diet (HFD) during pregnancy and lactation leads to metabolic disorders in offspring concomitant with increased adiposity and a proinflammatory phenotype in later life. During the fetal period, the impact of maternal diet on skeletal muscle development is poorly described, despite this tissue exerting a major influence on life-long metabolic health. This study investigated the effect of a maternal HFD on skeletal muscle anabolic, catabolic, and inflammatory signaling in adult rat offspring. Furthermore, the actions of maternal-supplemented conjugated linoleic acid (CLA) on these measures of muscle phenotype were investigated. A purified control diet (CD; 10% kcal fat), a CD supplemented with CLA (CLA; 10% kcal fat, 1% total fat as CLA), a high-fat (HFD; 45% kcal fat from lard), or a HFD supplemented with CLA (HFCLA; 45% kcal fat from lard, 1% total fat as CLA) was fed ad libitum to female Sprague-Dawley rats for 10 days before mating and throughout gestation and lactation. Male offspring received a standard chow diet from weaning, and the gastrocnemius was collected for analysis at day 150. Offspring from HF and HFCLA mothers displayed lower muscular protein content accompanied by elevated monocyte chemotactic protein-1, IL-6, and IL-1β concentrations. Phosphorylation of NF-κBp65 (Ser536) and expression of the catabolic E3 ligase muscle ring finger 1 (MuRF1) were increased in HF offspring, an effect reversed by maternal CLA supplementation. The present study demonstrates the importance of early life interventions to ameliorate the negative effects of poor maternal diet on offspring skeletal muscle development.

scholarly journals Connexin 43 expression in the testes during postnatal development of finasteride-treated male rat offspring

2018 ◽  
Vol 14 (6) ◽  
pp. 1471-1479 ◽  
Author(s):  
Agnieszka Kolasa-Wołosiuk ◽  
Kamila Misiakiewicz-Has ◽  
Irena Baranowska-Bosiacka ◽  
Izabela Gutowska ◽  
Maciej Tarnowski ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Connexin 43 ◽  
Male Rat ◽  
Treated Male ◽  
Rat Offspring

scholarly journals Maternal Folic Acid Impacts DNA Methylation Profile in Male Rat Offspring Associated With Neurodevelopment and Learning/Memory Abilities

2020 ◽  
Author(s):  
Xinyan Wang ◽  
Zhenshu Li ◽  
Yun Zhu ◽  
Jing Yan ◽  
Huan Liu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Gene Network ◽  
Underlying Mechanism ◽  
Male Rat ◽  
Methylated Dna ◽  
Rat Offspring ◽  
Kegg Pathway Analysis ◽  
Differentially Methylated Genes ◽  
Dna Methylation Profile ◽  
Gene Network Analysis

Abstract Background: Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetically regulated by FA in neurodevelopment were rarely reported. Methods: To elucidate the underlying mechanism, the effect of FA on the methylation profiles in brain tissue of male rat offspring was assessed by methylated DNA immunoprecipitation chip. Differentially methylated genes (DMGs) and gene network analysis were identified using DAVID and KEGG pathway analysis. Results: Compared with the FA-N group, 1939 DMGs were identified in the FA-D group, and 1498 DMGs were identified in the FA-S group, among which 298 DMGs were overlapped. The pathways associated with neurodevelopment and learning/memory abilities were differentially methylated in response to maternal FA intake during pregnancy, and there were some identical and distinctive potential mechanisms under FA deficiency or supplemented conditions. Conclusions: In conclusion, genes and pathways associated with neurodevelopment and learning/memory abilities were differentially methylated in male rat offspring in response to maternal FA deficiency or supplementation during pregnancy.

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