scholarly journals Association of specific diplotypes defined by common rs1800682 and rare rs34995925 single nucleotide polymorphisms within the STAT1 transcription binding site of the FAS gene promoter with preeclampsia

2014 ◽  
Vol 33 (02) ◽  
pp. 199-204 ◽  
Author(s):  
Zora Lasabova ◽  
Imrich Zigo ◽  
Iveta Svecova ◽  
Gabor Szabo ◽  
Andrea Stanclova ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Binding Site ◽  
Gene Promoter ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Association of Polymorphisms with Gastric Cancer: Single Nucleotide Polymorphisms in Promoter or Micro Rna Binding Site?

2014 ◽  
Vol 25 ◽  
pp. iv223
Author(s):  
S. Derakhshani ◽  
S. Baradaran Ghavami ◽  
B. Damavand ◽  
P. Azimzadeh ◽  
S.R. Mohebbi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Binding Site ◽  
Rna Binding ◽  
Micro Rna ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population

Reproduction ◽  
2007 ◽  
Vol 134 (2) ◽  
pp. 373-378 ◽  
Author(s):  
Kang Shan ◽  
Ma Xiao-Wei ◽  
Wang Na ◽  
Zhang Xiu-Feng ◽  
Wen Deng-Gui ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Chinese Women ◽  
Gene Promoter ◽  
Nucleotide Polymorphisms ◽  
Promoter Polymorphisms ◽  
Single Nucleotide ◽  
Altered Expression ◽  
Significant Difference ◽  
And Control ◽  
E Cadherin

Endometriosis, one of the most frequent diseases in gynecology, is a benign but invasive and metastatic disease. The altered expression of E-cadherin may play an important role in developing endometriosis. In this paper, we discuss the association of three single nucleotide polymorphisms (SNPs) on the E-cadherin gene and risk of endometriosis. We examined the genotype frequency of three polymorphisms in 152 endometriosis patients and 189 control women. There was a significant difference in the frequency of the E-cadherin 3′-UTR C → T genotypes between endometriosis and controls (P = 0.01). The frequency of the C allele in patients (71.1%) was significantly higher than in the controls (63.8%; P = 0.04). When compared with the T/T + T/C genotypes, the C/C genotype had a significantly increased susceptibility to endometriosis, with an adjusted odds ratio of 1.79 (95% confidence interval = 1.17–2.76). No significant difference was found between endometriosis and control women on two polymorphisms (−160 C → A, −347 G → GA) at the gene promoter region of E-cadherin. The −160 C → A and −347 G → GA polymorphisms displayed linkage disequilibrium (D′ = 0.999). The −160 A/−347 GA haplotype was only detected in endometriosis patients (2%). These data show a relation between the E-cadherin 3′-UTR C → T polymorphism, the −160 A/−347 GA haplotype of two promoter polymorphisms and risk of endometriosis, suggesting a potential role in endometriosis development, at least in North Chinese women.

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