scholarly journals Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR

2013 ◽  
Vol 32 (02) ◽  
pp. 235-243 ◽  
Author(s):  
Frantisek Kristek ◽  
Magdalena Malekova ◽  
Sona Cacanyiova
Nitric Oxide ◽  
2014 ◽  
Vol 39 ◽  
pp. S17
Author(s):  
Frantisek Kristek ◽  
Magdalena Malekova ◽  
Andreas Berenyiova ◽  
Karol Ondrias

2009 ◽  
pp. 327-335 ◽  
Author(s):  
R Koprdová ◽  
M Cebová ◽  
F Kristek

Alterations in geometry and structure of coronary arteries have marked consequences on blood flow to the respective area. We evaluated long-term effect of losartan on blood pressure (BP), heart weight/body weight (HW/BW), geometry and structure of septal branch of coronary artery (RS) of young SHR and Wistar rats. Four-week-old Wistar rats and SHR were used. Losartan was administered (20 mg/kg/day) in drinking water by gavage for 5 weeks. BP was measured by plethysmographic method. Cardiovascular system was perfused with a fixative (120 mm Hg). RS was processed for electron microscopy. Wall thickness of intima + media (WT), inner diameter (ID), cross-sectional area of intima + media (CSA), volume densities (VD) of endothelial cells (EC), extracellular matrix (ECM) of intima, smooth muscle cells (SMC) and ECM of media were evaluated. BP of 4-week-old SHR did not differ from that of Wistar rats. BP, HW/BW, WT, CSA, WT/ID, CSAs of SMC, ECM of media were increased in 9-weekold SHR, whereas their VD and CSA of EC were decreased. Losartan administration decreased BP and HW/BW in both groups. Geometry of RS was affected only in SHR (reduction of WT, CSA, WT/ID and increased of ID, circumferential tension, VD and CSA of EC). Losartan administration reduced BP and myocardial mass in both groups and beneficially affected geometry and structure of coronary artery in SHR.


2017 ◽  
Vol 39 ◽  
pp. 204-208 ◽  
Author(s):  
Maen Aboul Hosn ◽  
Brian Adams ◽  
Mark Pederson ◽  
Timothy Kresowik ◽  
Luigi Pascarella

2016 ◽  
Vol 55 (7) ◽  
pp. 769-773
Author(s):  
Mitsuhiro Kometani ◽  
Takashi Yoneda ◽  
Masashi Demura ◽  
Shigehiro Karashima ◽  
Shunsuke Mori ◽  
...  

The Lancet ◽  
1961 ◽  
Vol 278 (7217) ◽  
pp. 1373-1375 ◽  
Author(s):  
EleanorM. Adams ◽  
Ian Macgillivray

Author(s):  
Usman Sawar ◽  
◽  
Ali Hussain ◽  
Nikky Bardia ◽  
Hassan Tahir ◽  
...  

COVID-19 infection affects multiple organs including cardiovascular system. Besides acute effect in active infection, COVID-19 also has a long-term effect on the cardiovascular system and reporting of these effects are increasing along with increased number of survivors recovering from COVID-19 infection. In this article, we reviewed the current literature available for long-term effects of COVID-19 on the heart.


Hypertension ◽  
2002 ◽  
Vol 40 (6) ◽  
pp. 797-803 ◽  
Author(s):  
Mi Kyung Kim ◽  
Satoshi Sasaki ◽  
Shizuka Sasazuki ◽  
Shunji Okubo ◽  
Masato Hayashi ◽  
...  

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