scholarly journals Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

2012 ◽  
Vol 30 (04) ◽  
pp. 356-363 ◽  
Author(s):  
Dervis Ozcelik ◽  
Matem Tuncdemir ◽  
Melek Ozturk ◽  
Hafize Uzun
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Rat Model ◽  
Diabetic Rat ◽  
Stress Levels ◽  
And Oxidative Stress ◽  
Diabetic Rat Model

scholarly journals Analysis of the Effect of Fish Bars Made of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour to Reduce Oxidative Stress in a Diabetic Rat Model

2020 ◽  
Vol 66 (Supplement) ◽  
pp. S36-S40
Author(s):  
Deni ELNOVRIZA ◽  
Hadi RIYADI ◽  
Rimbawan RIMBAWAN ◽  
Evy DAMAYANTHI ◽  
Adi WINARTO
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model

Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes

Metabolism ◽  
2008 ◽  
Vol 57 (9) ◽  
pp. 1253-1261 ◽  
Author(s):  
Seonghun Ryu ◽  
Asher Ornoy ◽  
Amram Samuni ◽  
Sarah Zangen ◽  
Ron Kohen
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Diabetic Rat ◽  
Pancreatic Damage ◽  
High Sucrose ◽  
Diabetic Rat Model

Trace Elements and Oxidative Stress Levels in the Blood of Painters in Lagos, Nigeria: Occupational Survey and Health Concern

2013 ◽  
Vol 153 (1-3) ◽  
pp. 127-133 ◽  
Author(s):  
Olufunsho Awodele ◽  
Akin Akinyede ◽  
Omotola Opeyemi Babawale ◽  
Herbert A. Babatunde Coker ◽  
Alade Akintonwa
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Health Concern ◽  
Stress Levels ◽  
And Oxidative Stress

Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Titin Andri Wihastuti ◽  
Reyhan Amiruddin ◽  
Fibe Yulinda Cesa ◽  
Amalia Istiqamah Alkaf ◽  
Meddy Setiawan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Rat Model ◽  
Ganoderma Lucidum ◽  
Vasa Vasorum ◽  
Diabetic Rat ◽  
Diabetic Rat Model

AbstractBackgroundType 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM causes advanced formation of glycation end products (AGE) which leads to oxidative stress and chronic inflammation. Oxidative stress occurs due to increased levels of reactive oxygen species (ROS) such as H2O2. On the other hand, lipoprotein-associated phospholipase (Lp-PLA2) has pro-inflammatory effects, which cause instability of atherosclerosis plaques. This condition causes hypoxemic cells to stimulate HIFα induced vasa vasorum angiogenesis. This study aims to understand the potential of PSP as an anti-angiogenic agent through decreased levels of H2O2 and Lp-PLA2 leading to the decline of vasa vasorum angiogenesis in diabetic rat model. In addition, this study also measured the lipid profile of diabetic rat model in relation to vasa vasorum angiogenesis.MethodsTrue laboratory experiment with randomized post-test control of group design using 25 wistar rats (Rattus norvegicus) were divided into five groups; one normal group and four group with High Fat Diet (HFD) and low dose streptozotocin (30 mg/kgBW) injection sc, treated with placebo and three various doses of PSP 50, 150, 300 mg/kgBW.ResultsANOVA test (p < 0.05) shows that there is a significant influence of polysaccharide peptide (PSP) feeding on the decreased amount of vasa vasorum angiogenesis (p = 0.00), lipid profile (cholesterol total and triglyceride; p = 0.01, p = 0.001), and amount of H202 (p = 0.003). The amount of Lp-PLA2 declined to (p = 0.184). This result indicates that PSP prevents inflammation in atherosclerosis.ConclusionsPSP of Ganoderma lucidum is an anti-angiogenic agent in T2DM.

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