scholarly journals Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats

2020 ◽  
Vol 121 (07) ◽  
pp. 504-511
Author(s):  
Z. Doganyigit ◽  
B. Yakan ◽  
M. Soylu ◽  
E. Kaymak ◽  
A. Okan ◽  
...  
Keyword(s):  
Stomach Tissue ◽  
Biochemical Effects ◽  
Bee Bread ◽  
Obese Rats

scholarly journals The Effects of Feeding Obese Rats by Bee Bread on IL-6 Expression in Rat Stomach

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1570
Author(s):  
Zuleyha Doganyigit ◽  
Birkan Yakan ◽  
Emin Kaymak
Keyword(s):  
Interleukin 6 ◽  
High Fat Diet ◽  
High Fat ◽  
Rat Stomach ◽  
Bee Bread ◽  
Obese Rats

The aim of this project was the determination of the effect of bee bread supplement in diets of obese rats on interleukin 6 immunreactivity. This study has been shown that bee bread against obesity with a high-fat diet reduces IL-6 expression in the stomach.

scholarly journals Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats

Antioxidants ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 33 ◽  
Author(s):  
Zaidatul Akmal Othman ◽  
Wan Syaheedah Wan Ghazali ◽  
Liza Noordin ◽  
Nurul Aiman Mohd. Yusof ◽  
Mahaneem Mohamed
Keyword(s):  
Phenolic Compounds ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Antioxidant Activities ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Sprague Dawley ◽  
High Fat ◽  
Bee Bread ◽  
Obese Rats

This study was undertaken to determine the phenolic compounds and the anti-atherogenic effect of bee bread in high-fat diet (HFD)-induced obese rats. The presence of phenolic compounds in bee bread was determined by liquid chromatography–mass spectrometry. Thirty-two male Sprague Dawley rats were divided into four groups, (n = 8/group); i.e., Normal (N), HFD (high-fat diet), HFD + BB (high-fat diet and 0.5 g/kg/day bee bread), and HFD + O (high-fat diet and 10 mg/kg/day orlistat) groups. After 6 weeks of the experiment, rats were sacrificed. Five phenolic compounds were identified in bee bread; namely, caffeic acid, ferulic acid, kaempferol, apigenin, and isorhamnetin. Bee bread significantly reduced Lee obesity index and levels of total cholesterol (TC), low-density lipoprotein (LDL), fatty acid synthase (FAS) activity, atherogenic index, oxidised-LDL (oxLDL), and malondialdehyde (MDA), and significantly increased aortic antioxidant activities, such as those of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Adipocyte sizes were found to be smaller in the HFD + BB group compared to the N group, and en face aortas showed an absence of atherosclerotic plaque in rats supplemented with bee bread. These changes might suggest an anti-atherogenic effect of bee bread in HFD-induced obese rats via its antioxidant and hypocholesterolaemic properties.

scholarly journals Behavioral And Biochemical Effects Of Pharmacopuncture (ST 21 And ST 40) In Obese Rats

2020 ◽  
pp. 1-7
Author(s):  
Mariana Chiste Pontes ◽  
Keyword(s):  
Abdominal Fat ◽  
The Other ◽  
Biochemical Tests ◽  
Glucose Levels ◽  
Biochemical Effects ◽  
Obese Rats ◽  
Calorie Diet ◽  
High Calorie Diet ◽  
Perirenal Fat ◽  
High Calorie

Obesity is considered a disease of the century and several treatment methods have been researched. Traditional Chinese medicine describes several findings that can be used to treat this disease. Thus, the aim of the present study was to evaluate, from an experimental perspective of Western medicine, the biochemical and behavioral effects of pharmacopuncture (21 and 40) in obese Wistar rats. The HDP21 group, treated with pharmacopuncture, exhibited a reduction in body weight compared to controls, who were also fed a high-calorie diet. In the eating behavior test, the latency was lower in the HDP40 group, and in this group, animals consumed with a higher number of cereals compared to other obese groups, or with suggestions of high acupuncture or appetite in this group. The HDP21 group, on the other hand, exhibited the shortest time in closed arms when compared to the other groups, suggesting a reduction in anxiety. Regarding the perirenal fat weight and abdominal postmortem of groups fed a high calorie diet, the HDP21 group had the lowest weight of perirenal fat and abdominal fat compared to the others. Similarly, a reduction in cholesterol, triglyceride and glucose levels was observed in the HDP21 group compared to other groups that received a high calorie diet. In conclusion, the present study demonstrated the effectiveness of the pharmacopuncture that uses bee venom in ST21 with weight loss in obese rats, as well as the reduction in biochemical tests and with loss of anxiety.

scholarly journals The effects of feeding obese rats with bee bread on leptin and ghrelin expression

2020 ◽  
Vol 44 (2) ◽  
pp. 114-125
Author(s):  
Züleyha DOĞANYİĞİT ◽  
Birkan YAKAN ◽  
Meltem SOYLU ◽  
Emin KAYMAK ◽  
Sibel SİLİCİ
Keyword(s):  
Bee Bread ◽  
Obese Rats

scholarly journals Behavioral and biochemical effects of pharmacopuncture (ST 36 and ST 25) in obese rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Mariana Chiste Pontes ◽  
Lilian Cardoso Heck ◽  
Janice Carneiro Coelho
Keyword(s):  
Biochemical Effects ◽  
Obese Rats

scholarly journals Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway

2021 ◽  
Vol 22 (8) ◽  
pp. 4225
Author(s):  
Zaidatul Akmal Othman ◽  
Zaida Zakaria ◽  
Joseph Bagi Suleiman ◽  
Victor Udo Nna ◽  
Aminah Che Romli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lipid Profile ◽  
Signaling Pathway ◽  
Structural Damage ◽  
Vascular Inflammation ◽  
Vascular Damage ◽  
Guanosine Monophosphate ◽  
Bee Bread ◽  
Obese Rats ◽  
Cgmp Signaling

Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role.

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Load-Bearing in the Ovine Medial Tibial Condyle: Effect of Meniscectomy

1993 ◽  
Vol 06 (02) ◽  
pp. 100-104 ◽  
Author(s):  
D. M. Pickles ◽  
C. R. Bellenger
Keyword(s):  
Knee Joint ◽  
Contact Area ◽  
Mammalian Species ◽  
Total Removal ◽  
Load Bearing ◽  
Human Knee ◽  
Biochemical Effects ◽  
Pressure Sensitive ◽  
Medial Meniscectomy ◽  
Tibial Condyle

SummaryTotal removal of a knee joint meniscus is followed by osteoarthritis in many mammalian species. Altered load-bearing has been observed in the human knee following meniscectomy but less is known about biochemical effects of meniscectomy in other species. Using pressure sensitive paper in sheep knee (stifle) joints it was found that, for comparable loads, the load-bearing area on the medial tibial condyle was significantly reduced following medial meniscectomy. Also, for loads of between 50 N and 500 N applied to the whole joint, the slope of the regression of contact area against load was much smaller. Following medial meniscectomy, the ability to increase contact area as load increased was markedly reduced.The load bearing area on the medial tibial condyle was reduced following meniscectomy.

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