scholarly journals The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: a meta-analysis of 1,407 cases and 974 control studies

2019 ◽  
Vol 120 (05) ◽  
pp. 349-355
Author(s):  
R. Ibrahimi ◽  
M. Musavi ◽  
M. Shojaee ◽  
M. Moossavi ◽  
S. Z. Moossavi ◽  
...  
Keyword(s):  
Male Infertility ◽  
Meta Analysis ◽  
Xrcc1 Arg399gln

An Insight into Novel Sperm Cell Proteins as Bio-markers for Male Infertility: A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Naina Kumar ◽  
Namit Kant Singh
Keyword(s):  
Male Infertility ◽  
Sperm Motility ◽  
Zona Pellucida ◽  
English Language ◽  
Semen Analysis ◽  
Meta Analysis ◽  
Sperm Dna Damage ◽  
Sperm Proteins

: Male infertility is rising now-a-days and accounts for major part of infertility cases worldwide. Novel tests are being developed for better detection and management of male infertility. Though there are many tests available for diagnosing male infertility like acrosome reaction rate, hemizona assay, in vivo or in vitro sperm penetration assay, sperm DNA damage tests, but semen analysis is most commonly used initial test for male infertility. It is usually associated with failure to detect cause in many cases, as seminal composition gets affected by a number of factors and can give false reports. Furthermore, it does not give any information about defects in capacitation, sperm Zona Pellucida interaction and sperm’s ability to fertilize oocytes. This results in failure of detection and delayed management of male infertility. Hence, the present review was conducted to identify various sperm proteins that play significant role in spermatogenesis, sperm motility, sperm-Zona Pellucida interaction and fertilization. These proteins can be used in future as markers of male infertility and will aid in better detection and management of male infertility. Methodology: Search for literature was made from 1970 to 2020 from various databases like PUBMED, SCOPUS, Google Scholar on sperm proteins and their role in male fertility using keywords: “sperm protein as bio-markers”, “novel sperm proteins as markers of infertility”, “Sperm proteins essential for capacitation, sperm motility and oocyte fertilization”. Inclusion criteria: All full-length research articles, systematic reviews, meta-analysis or abstracts on sperm proteins and male infertility published in English language in peer-reviewed journals were considered.

scholarly journals Effectiveness of Pharmacological Intervention Among Men with Infertility: A Systematic Review and Network Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Muhammad Nabeel Shahid ◽  
Tahir Mehmood Khan ◽  
Chin Fen Neoh ◽  
Qi Ying Lean ◽  
Allah Bukhsh ◽  
...  
Keyword(s):  
Male Infertility ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Random Effect ◽  
Random Effect Model ◽  
Sperm Concentration ◽  
Pharmacological Intervention ◽  
Total Testosterone ◽  
Pharmacological Interventions ◽  
Testosterone Undecanoate

Background. Infertility is an emerging health issue for men. Comparative efficacy of different pharmacological interventions on male infertility is not clear. The aim of this review is to investigate the efficacy of various pharmacological interventions among men with idiopathic male infertility. All randomized control trials evaluating the effectuality of interventions on male infertility were included for network meta-analysis (NMA) from inception to 31 April 2020, systematically performed using STATA through the random effect model. The protocol was registered at PROSPERO (CRD42020152891).Results. The outcomes of interest were semen and hormonal parameters. Treatment effects (p < 0.05) were estimated through WMD at the confidence interval of 95%. Upon applying exclusion criteria, n=28 RCTs were found eligible for NMA. Results from NMA indicated that consumption of supplements increases sperm concentration levels [6.26, 95% CI 3.32, 9.21] in comparison to SERMs [4.97, 95% CI 1.61, 8.32], hormones [4.14, 95% CI 1.83, 6.46], and vitamins [0.15, 95% CI −20.86, 21.15)] with placebo, whereas the use of SERMs increased percentage sperm motility [6.69, 95% CI 2.38, 10.99] in comparison to supplements [6.46, 95% CI 2.57, 10.06], hormones [3.47, 95% CI 0.40, 6.54], and vitamins [−1.24, 95% CI −11.84, 9.43] with placebo. Consumption of hormones increased the sperm morphology [3.71, 95% CI, 1.34, 6.07] in contrast to supplements [2.22, 95% CI 0.12, 4.55], SERMs [2.21, 95% CI −0.78, 5.20], and vitamins [0.51, 95% CI −3.60, 4.62] with placebo. Supplements boosted the total testosterone levels [2.70, 95% CI 1.34, 4.07] in comparison to SERMs [1.83, 95% CI 1.16, 2.50], hormones [0.40, 95% CI −0.49, 1.29], and vitamins [−0.70, 95% CI −6.71, 5.31] with placebo. SERMs increase the serum FSH levels [3.63, 95% CI 1.48, 5.79] better than hormones [1.29, 95% CI −0.79, 3.36], vitamins [0.03, 95% CI −2.69, 2.76], and supplements [−4.45, 95% CI −7.15, −1.76] in comparison with placebo.Conclusion. This review establishes that all interventions had a significantly positive effect on male infertility. Statistically significant increased sperm parameters were noted in combinations of zinc sulfate (220 mg BID), clomiphene citrate (50 mg BID), and testosterone undecanoate and CoQ10; tamoxifen citrate and FSH were shown to improve the hormonal profile in infertile males.

scholarly journals The XRCC1 Arg399Gln Genetic Polymorphism Contributes to Hepatocellular Carcinoma Susceptibility: An Updated Meta-analysis

2013 ◽  
Vol 14 (10) ◽  
pp. 5761-5767 ◽  
Author(s):  
Yan Pan ◽  
Lei Zhao ◽  
Xing-Miao Chen ◽  
Yong Gu ◽  
Jian-Gang Shen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Polymorphism ◽  
Meta Analysis ◽  
Xrcc1 Arg399gln

scholarly journals Effects of Primary Varicocele and Related Surgery in Male Infertility: A Meta-Analysis

2020 ◽  
Vol 7 ◽  
Author(s):  
Xinkun Wang ◽  
Tong Chen ◽  
Junfeng Qiu ◽  
Hongwei Wu ◽  
Xuehua Chen ◽  
...  
Keyword(s):  
Male Infertility ◽  
Meta Analysis

scholarly journals GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Wei Wu ◽  
Jing Lu ◽  
Qiuqin Tang ◽  
Simin Zhang ◽  
Beilei Yuan ◽  
...  
Keyword(s):  
Male Infertility ◽  
Meta Analysis
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