scholarly journals The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases

2019 ◽  
Vol 120 (03) ◽  
pp. 188-194
Author(s):  
A. Senyigit ◽  
H. Uzun ◽  
I. Gultepe ◽  
D. Konukoglu
Keyword(s):  
Cardiovascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Dipeptidyl Peptidase ◽  
Diabetic Patients ◽  
Related Protein ◽  
Dipeptidyl Peptidase 4 ◽  
Media Thickness ◽  
The Relationship

scholarly journals The Effect of Dipeptidyl Peptidase-4 Inhibitors on Carotid Intima-media Thickness in Patients With Type 2 Diabetes Mellitus: a Meta-analysis

2020 ◽  
Author(s):  
Hua-song Xia ◽  
Yue Liu ◽  
Yang Fu ◽  
Meng Li ◽  
Yan-qing Wu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 4 ◽  
Media Thickness ◽  
Dipeptidyl Peptidase 4 Inhibitors

Abstract BACKGROUND: It is reported that dipeptidyl peptidase-4 (DPP-4) inhibitors can exert a protective effect on the cardiovascular system other than the glucose-lowering effect. However, whether DPP-4 inhibitors can delay or prevent the progression of carotid intima-media thickness (IMT), a marker for atherosclerosis, is not clear. METHODS: An extensive literature search was performed up to December 2019.Double-blind, randomized controlled trials that compare the effect of DPP-4 inhibitors with conventional therapy were included. The primary outcome was IMT of carotid.RESULTS: Four studies in total involving 1141 participants were enrolled. The results indicated that DPP-4 inhibitors group showed significant decreases in IMT (- 0.022 mm, P = 0.053) when compared with control group, but it was not statistically significant. There was also a decrease in hemoglobin A1c (HbA1c) (- 0.16%, p < 0.001) in DPP-4 inhibitors groups in comparison with control groups.CONCLUSION: Our study demonstrates DPP-4 inhibitors administrated in type 2 diabetes mellitus have no protective effects on carotid IMT compared with conventional/placebo treatment.

scholarly journals Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy

2012 ◽  
Vol 3 ◽  
pp. 484-490 ◽  
Author(s):  
Anita Rogowicz-Frontczak ◽  
Aleksandra Araszkiewicz ◽  
Stanislaw Pilacinski ◽  
Dorota Zozulinska-Ziolkiewicz ◽  
Andrzej Wykretowicz ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Media Thickness ◽  
Type 1 Diabetic Patients

scholarly journals PERCENTILE DISTRIBUTION OF CAROTID INTIMA-MEDIA THICKNESS IN THE GENERAL WORKING-AGE POPULATION

2019 ◽  
Vol 34 (1) ◽  
pp. 145-151
Author(s):  
Kaveshnikov Kaveshnikov ◽  
V. N. Serebryakova ◽  
I. A. Trubacheva
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Informed Consent Form ◽  
Gender And Age ◽  
Working Age ◽  
The Mean ◽  
Working Age Population

Objective.To study the gender- and age-specific percentile distribution of carotid intima-media thickness (cIMT) in the unorganized urban working-age population.Material and Methods. Presented data were obtained in the ESSE-RF study in the city of Tomsk (1,412 participants, 25–64 years old without cardiovascular diseases, 59% women). All the surveyed signed voluntary informed consent form to participate in the study. We studied distributions of the mean and maximum cIMT obtained by the automatic and manual measurements, respectively. An error probability of less than 5% was considered statistically significant.Results. Both indicators of cIMT consistently increased with age in both gender groups. Maximum cIMT (max-cIMT) increased stronger than the mean cIMT (mean-cIMT). Compared with data obtained in other studies, the mean-cIMT estimates were distributed closer to the upper pole of the spectrum presented and increased stronger in 35–55-year-old men compared with those in the populations of Central and Southwestern Europe; the mean-cIMT estimates showed the most pronounced gender effect. Similar trends were identified in relation to the max-cIMT distribution.Conclusion. Obtained data allowed for specific assessment of the individual cIMT values by gender and age within the framework of risk stratification among people of working age without cardiovascular diseases. Further studies aimed at clarifying the prognostic role of high cIMT values in general population, taking into account the influence of traditional and new cardiovascular risk factors, can broaden the understanding of the significance of vascular state assessment as one of the key points, linking risk factors to clinical events, for primary prevention of cardiovascular diseases in population.

Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Cardiology ◽  
2013 ◽  
Vol 125 (3) ◽  
pp. 150-153 ◽  
Author(s):  
Alberto F. Rubio-Guerra ◽  
Luis J. Cabrera-Miranda ◽  
Hilda Vargas-Robles ◽  
Alberto Maceda-Serrano ◽  
José J. Lozano-Nuevo ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Media Thickness ◽  
Type 2 Diabetic
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