scholarly journals Association between interleukin 4 (IL-4) VNTR, gene polymorphism, and breast cancer susceptibility in Iranian population: experimental and web base analysis

2018 ◽  
Vol 119 (10) ◽  
pp. 651-654
Author(s):  
M. Ibrahimi ◽  
B. Jamalzei ◽  
M. E. Akbari ◽  
R. Ibrahimi ◽  
M. Alaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Iranian Population ◽  
Interleukin 4 ◽  
Base Analysis

Association between LAPTM4B gene polymorphism and breast cancer susceptibility in an Iranian population

2014 ◽  
Vol 31 (8) ◽  
Author(s):  
Mohammad Hashemi ◽  
Sahadi Amininia ◽  
Mahboubeh Ebrahimi ◽  
Seyed Mehdi Hashemi ◽  
Javad Yousefi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Iranian Population

Relevance of GSTM1, GSTT1 and GSTP1 Gene Polymorphism to Breast Cancer Susceptibility in Mizoram Population, Northeast India

2015 ◽  
Vol 54 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Lalro Kimi ◽  
Souvik Ghatak ◽  
Ravi Prakash Yadav ◽  
Lalhma Chhuani ◽  
Doris Lallawmzuali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Northeast India ◽  
Gstp1 Gene

Association of LAPTM4B gene polymorphism with breast cancer susceptibility

2012 ◽  
Vol 36 (4) ◽  
pp. 364-368 ◽  
Author(s):  
Meirong Fan ◽  
Ye Liu ◽  
Rouli Zhou ◽  
Qingyun Zhang
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility

Genetic polymorphisms in long noncoding RNA H19 are associated with breast cancer susceptibility in Iranian population

Meta Gene ◽  
2017 ◽  
Vol 14 ◽  
pp. 1-5 ◽  
Author(s):  
Shekoufeh Hassanzarei ◽  
Mohammad Hashemi ◽  
Hedieh Sattarifard ◽  
Seyed Mehdi Hashemi ◽  
Gholamreza Bahari
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphisms ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Iranian Population

CD243 gene polymorphism significantly associated with breast cancer susceptibility

Tumor Biology ◽  
2014 ◽  
Vol 35 (8) ◽  
pp. 8017-8022 ◽  
Author(s):  
Weirong Yao ◽  
Rongzeng Yan ◽  
Lin Ma ◽  
Huiping Wan ◽  
Yanmin Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility

Significant Association of miR-605 rs2043556 with Susceptibility to Breast Cancer

MicroRNA ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 133-141
Author(s):  
Arezu Kazemi ◽  
Sadeq Vallian
Keyword(s):  
Breast Cancer ◽  
Noncoding Rna ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Allelic Frequency ◽  
Iranian Population ◽  
P Value ◽  
Nucleotide Polymorphisms ◽  
Mirna Genes ◽  
Increased Risk

Background: MicroRNAs (miRNAs) are noncoding RNA molecules, which directly regulate gene expression. It has been documented that single nucleotide polymorphisms in miRNA genes could alter the regulation of miRNA expression and function. Objective: In this study, the allele and genotype frequency of miR-605 rs2043556 and its association with breast cancer were investigated in the Iranian population. Methods: Genotyping was performed in 162 females affected with breast cancer and 180 healthy individuals. Genotyping was performed using Restriction Fragment Length Polymorphism (RFLP) followed by Sanger sequencing. Results: The data showed the presence of Hardy Weinberg equilibrium (HWE) for this marker in the Iranian population. Allelic frequency for A and G allele was 0.75 and 0.25, respectively. Odd ratios for the association between miR-605 rs2043556 AG/GG genotypes was 3.86 with p-value= 0. Conclusion: The results indicated an increased risk for breast cancer susceptibility for miR-605 rs2043556 in the Iranian population.

scholarly journals Toll-like receptor 5 gene polymorphism is associated with breast cancer susceptibility

Oncotarget ◽  
2017 ◽  
Vol 8 (51) ◽  
pp. 88622-88629 ◽  
Author(s):  
Chen Shuang ◽  
Yuan Weiguang ◽  
Fu Zhenkun ◽  
Huang Yike ◽  
Yang Jiankun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphism ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Toll Like Receptor ◽  
Toll Like Receptor 5

scholarly journals OX40L GENE POLYMORPHISM AND BREAST CANCER IN IRANIAN POPULATION

2018 ◽  
Vol 40 (2) ◽  
pp. 132-135 ◽  
Author(s):  
R Vakil Monfared ◽  
F Mashayekhi
Keyword(s):  
Breast Cancer ◽  
Statistical Analysis ◽  
Healthy Volunteers ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Allelic Frequency ◽  
Iranian Population ◽  
Genotype Frequencies ◽  
Significant Difference ◽  
Genetic And Environmental Factors

Background and Aim: The immune system plays an important role in the breast cancer development. OX40L (also known as TNFSF4), a membrane protein, which is a member of the tumor necrosis factor super family binds to its receptor OX40 and this co-stimulation has a crucial role in T cell proliferation, survival and cytokine release. Previous studies have shown that OX40L is associated with cancer. Due to the importance of the T cells in antitumor activities of OX40L we studied the association of rs3850641 (A→G) polymorphism of OX40L gene with the breast cancer. Materials and Methods: The study included 123 women with breast cancer and 126 healthy volunteers with no signs of cancer. Genomic DNA was extracted from blood leucocytes. Genotype and allele frequencies were determined in patients and control cases with the method of polymerase chain reaction-restriction fragment length polymorphism and the statistical analysis was performed by Med Calc. Results: The prevalence of genotype frequencies of AA/ AG/GG were 60.9%, 30.08% and 8.9% in patients with breast cancer cases and 74.6%, 18.25% and 7.14% in healthy volunteers while the A and G allelic frequency was 76.01 and 23.98% in patients and 83.73 and 16.26% in healthy controls, respectively. Statistical analysis has shown significant difference from the comparison of genotype (p = 0.03). Conclusion: It is concluded that the rs3850641 SNP is significantly associated with the breast cancer susceptibility in Iranian population. However, further studies in larger populations including other genetic and environmental factors are required to achieve conclusion.

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