scholarly journals Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats

2018 ◽  
Vol 119 (02) ◽  
pp. 86-91
Author(s):  
T. Yildirim ◽  
O. Okutan ◽  
E. Akpinar ◽  
A. Yilmaz ◽  
H. S. Isik
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Human Albumin ◽  
High Dose ◽  
Traumatic Spinal Cord Injury ◽  
Neuroprotective Effects ◽  
Cord Injury

scholarly journals 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and “cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats

2020 ◽  
Vol 29 ◽  
pp. 096368972095022
Author(s):  
Liansheng Gao ◽  
Chun Wang ◽  
Bing Qin ◽  
Tao Li ◽  
Weilin Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Apoptosis ◽  
Neurological Impairment ◽  
White Matter Injury ◽  
Traumatic Spinal Cord Injury ◽  
Cyclin Dependent Kinase ◽  
Neuroprotective Effects ◽  
Cord Injury

Apoptosis is a vital pathological factor that accounts for the poor prognosis of traumatic spinal cord injury (t-SCI). The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is a critical regulator for energy metabolism and proven to have antiapoptotic effects. This study aimed to investigate the neuroprotective role of PFKFB3 in t-SCI. A compressive clip was introduced to establish the t-SCI model. Herein, we identified that PFKFB3 was extensively distributed in neurons, and PFKFB3 levels significantly increased and peaked 24 h after t-SCI. Additionally, knockdown of PFKFB3 inhibited glycolysis, accompanied by aggravated neuronal apoptosis and white matter injury, while pharmacological activation of PFKFB3 with meclizine significantly enhanced glycolysis, attenuated t-SCI-induced spinal cord injury, and alleviated neurological impairment. The PFKFB3 agonist, meclizine, activated cyclin-dependent kinase 1 (CDK1) and promoted the phosphorylation of p27, ultimately suppressing neuronal apoptosis. However, the neuroprotective effects of meclizine against t-SCI were abolished by the CDK1 antagonist, RO3306. In summary, our data demonstrated that PFKFB3 contributes robust neuroprotection against t-SCI by enhancing glycolysis and modulating CDK1-related antiapoptotic signals. Moreover, targeting PFKFB3 may be a novel and promising therapeutic strategy for t-SCI.

scholarly journals High-Dose Neural Stem/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Taoyang Yuan ◽  
Qian Liu ◽  
Jie Kang ◽  
Hua Gao ◽  
Songbai Gui
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Network Formation ◽  
Donor Cell ◽  
High Dose ◽  
Lesion Area ◽  
Neuroprotective Effects ◽  
Cord Injury ◽  
Neuronal Distribution

Severe spinal cord injury (SCI) leads to permanent, complete paraplegia and places considerable mental and economic burdens on patients, compared with mild to moderate SCI. However, the dose-related effects of the neural stem/precursor cell (NSPC) transplantation on the injury microenvironment, NSPC survival, axonal growth, neuronal distribution, the composition of neurons, oligodendrocytes, and astrocytes in the lesion area and functional recovery have not yet been quantitatively evaluated in the context of severe SCI. In our study, we acutely transplanted 2.5×104 or 1.5×105 NSPCs/μl into the site of transection SCI. We found that high-dose NSPC transplantation exerted immunomodulatory and neuroprotective effects in the acute phase of severe SCI. In addition, one week later, a remarkable positive relationship was observed between the transplantation dose and the number of surviving NSPCs in severe SCI. At 8 weeks postgrafting, subjects that received the higher cell dose exhibited abundant nerve regeneration, extensive neuronal distribution, increased proportions of neurons and oligodendrocytes, and nascent functional neural network formation in the lesion area. Notably, a significant functional recovery was also observed. Our data suggest that it is important to consider potential dose-related effects on donor cell survival, neuronal distribution, and locomotor recovery in the development of preclinical NSPC transplantation therapy for severe SCI.

scholarly journals Epidemiological and Clinical Features, Treatment Status, and Economic Burden of Traumatic Spinal Cord Injury in China

2021 ◽  
Author(s):  
Shiqing feng ◽  
Hengxing Zhou ◽  
Yongfu Lou ◽  
Lingxiao Chen ◽  
Yi Kang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Features ◽  
Economic Burden ◽  
National Level ◽  
Hospitalized Patients ◽  
High Dose ◽  
Traumatic Spinal Cord Injury ◽  
Treatment Status ◽  
Cord Injury

Background <br />China has the largest population of traumatic spinal cord injury (TSCI), but has not yet performed a national-level study on its epidemiological and clinical features, treatment status, and economic burden. <br />Methods A total of 14 754 patients were recruited between January 2013 and December 2018 from 37 hospitals in 11 provinces and municipalities, which represented all geographical divisions of China. The percentage of TSCI in hospitalized patients and the percentage of TSCI in hospitalized patients through the orthopaedic departments were calculated. The treatment status, total and daily costs were collected. <br />Results The percentage of TSCI in hospitalized patients and the percentage of TSCI in hospitalized patients through the orthopaedic departments did not change significantly overall (APC= -0.5%, 95% CI: -3.0 to 2.1 and -1.6%, -4.9 to 1.8, respectively). A total of 10 918 (74.0%) patients received surgery after TSCI. However, only 3.0% of patients underwent surgery received surgery less than 24 hours after injury. A total of 2 084 (14.1%) patients were treated with methylprednisolone sodium succinate/methylprednisolone (MPSS/MP) at a high dose (?500 mg) and 641 (4.3%) patients receiving it within 8 hours. The total costs for acute TSCI decreased (-4.8%, -6.2 to -3.4), while the daily costs did not change significantly (0.5%, -1.2 to 2.2). <br />Conclusions This study revealed epidemiological and clinical features, treatment status, and economic burden of TSCI that occurred in China from 2013 to 2018.<br />Funding National Key Research and Development Project of Stem Cell and Transformation Research (2019YFA0112100).

scholarly journals Neuroprotective effects of lacosamide in experimental traumatic spinal cord injury in rats

2019 ◽  
Author(s):  
Serdar Demiroz ◽  
Koray Ur ◽  
Aykut Ulucan ◽  
Aydin Sukru Bengu ◽  
Feyza Demiralin Ur ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Traumatic Spinal Cord Injury ◽  
Neuroprotective Effects ◽  
Cord Injury

Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats

Injury ◽  
2015 ◽  
Vol 46 (11) ◽  
pp. 2146-2155 ◽  
Author(s):  
Emre Cemal Gokce ◽  
Ramazan Kahveci ◽  
Osman Malik Atanur ◽  
Bora Gürer ◽  
Nurkan Aksoy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ganoderma Lucidum ◽  
Traumatic Spinal Cord Injury ◽  
Neuroprotective Effects ◽  
Ganoderma Lucidum Polysaccharides ◽  
Cord Injury

The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats

2005 ◽  
Vol 64 (3) ◽  
pp. 213-220 ◽  
Author(s):  
Şeref Barut ◽  
Yusuf Atilla Ünlü ◽  
Alper Karaoğlan ◽  
Matem Tunçdemir ◽  
Fatma Kaya Dağistanli ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Caspase 3 ◽  
Traumatic Spinal Cord Injury ◽  
Neuroprotective Effects ◽  
Cord Injury

Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats

2014 ◽  
Vol 741 ◽  
pp. 45-54 ◽  
Author(s):  
Ramazan Kahveci ◽  
Emre Cemal Gökçe ◽  
Bora Gürer ◽  
Aysun Gökçe ◽  
Uçler Kisa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Traumatic Spinal Cord Injury ◽  
Neuroprotective Effects ◽  
Cord Injury
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