scholarly journals Effect of apelin-13 on erythrocyte deformability during ischaemia–reperfusion injury of heart in diabetic rats

2017 ◽  
Vol 118 (03) ◽  
pp. 133-136 ◽  
Author(s):  
H. Kartal ◽  
F. M. Comu ◽  
A. Kucuk ◽  
Y. Polat ◽  
A. D. Dursun ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Diabetic Rats ◽  
Erythrocyte Deformability ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Inhibition of Rho kinase protects from ischaemia–reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes

2017 ◽  
Vol 14 (3) ◽  
pp. 236-245 ◽  
Author(s):  
Yahor Tratsiakovich ◽  
Attila Kiss ◽  
Adrian T Gonon ◽  
Jiangning Yang ◽  
Per-Ove Sjöquist ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Type 1 Diabetes ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Diabetic Rats ◽  
Arginase Activity ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Oxide Synthase

Aim: RhoA/Rho-associated kinase and arginase are implicated in vascular complications in diabetes. This study investigated whether RhoA/Rho-associated kinase and arginase inhibition protect from myocardial ischaemia–reperfusion injury in type 1 diabetes and the mechanisms behind these effects. Methods: Rats with streptozotocin-induced type 1 diabetes and non-diabetic rats were subjected to 30 min myocardial ischaemia and 2 h reperfusion after being randomized to treatment with (1) saline, (2) RhoA/Rho-associated kinase inhibitor hydroxyfasudil, (3) nitric oxide synthase inhibitor NG-monomethyl-l-arginine monoacetate followed by hydroxyfasudil, (4) arginase inhibitor N-omega-hydroxy-nor-l-arginine, (5) NG-monomethyl-l-arginine monoacetate followed by N-omega-hydroxy-nor-l-arginine or (6) NG-monomethyl-l-arginine monoacetate given intravenous before ischaemia. Results: Myocardial arginase activity, arginase 2 expression and RhoA/Rho-associated kinase activity were increased in type 1 diabetes ( p < 0.05). RhoA/Rho-associated kinase inhibition and arginase inhibition significantly reduced infarct size in diabetic and non-diabetic rats ( p < 0.001). The cardioprotective effects of hydroxyfasudil and N-omega-hydroxy-nor-l-arginine in diabetes were abolished by nitric oxide synthase inhibition. RhoA/Rho-associated kinase inhibition attenuated myocardial arginase activity in diabetic rats via a nitric oxide synthase–dependent mechanism. Conclusion: Inhibition of either RhoA/Rho-associated kinase or arginase protects from ischaemia–reperfusion injury in rats with type 1 diabetes via a nitric oxide synthase–dependent pathway. These results suggest that inhibition of RhoA/Rho-associated kinase and arginase constitutes a potential therapeutic strategy to protect the diabetic heart against ischaemia–reperfusion injury.

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

2015 ◽  
Vol 116 (01) ◽  
pp. 47-50
Author(s):  
M. Arslan ◽  
F. M. Comu ◽  
M. Alkan ◽  
H. A. Kiraz ◽  
G. Kip ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Erythrocyte Deformability ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
Sign in / Sign up

Export Citation Format

Share Document