scholarly journals Identification of the membrane-spanning domain of glycoprotein 45 in bovine immunodeficiency virus

2018 ◽  
Vol 62 (03) ◽  
pp. 294-303
Author(s):  
W. SHEN ◽  
J. FENG ◽  
Z. LIU ◽  
D. DIAO ◽  
CH. LIU ◽  
...  
Keyword(s):  
Bovine Immunodeficiency Virus ◽  
Immunodeficiency Virus ◽  
Membrane Spanning

scholarly journals Bovine HEXIM1 inhibits bovine immunodeficiency virus replication through regulating BTat-mediated transactivation

2013 ◽  
Vol 44 (1) ◽  
pp. 21 ◽  
Author(s):  
Hong-yan Guo ◽  
Yong-gang Ma ◽  
Yuan-ming Gai ◽  
Zhi-bin Liang ◽  
Jing Ma ◽  
...  
Keyword(s):  
Virus Replication ◽  
Bovine Immunodeficiency Virus ◽  
Immunodeficiency Virus

A Synthetic Rev-Independent Bovine Immunodeficiency Virus-Based Packaging Construct

2004 ◽  
Vol 15 (9) ◽  
pp. 865-877 ◽  
Author(s):  
Rene P. Molina ◽  
Hongqing Q. Ye ◽  
James Brady ◽  
Jingli Zhang ◽  
Heather Zimmerman ◽  
...  
Keyword(s):  
Bovine Immunodeficiency Virus ◽  
Immunodeficiency Virus

scholarly journals Functional Differences between Human and Bovine Immunodeficiency Virus Tat Transcription Factors

2000 ◽  
Vol 74 (10) ◽  
pp. 4666-4671 ◽  
Author(s):  
Hal P. Bogerd ◽  
Heather L. Wiegand ◽  
Paul D. Bieniasz ◽  
Bryan R. Cullen
Keyword(s):  
Cooperative Interaction ◽  
Bovine Immunodeficiency Virus ◽  
Viral Gene ◽  
Tat Protein ◽  
Cyclin T1 ◽  
Immunodeficiency Virus ◽  
Cellular Cofactor ◽  
Ltr Promoter ◽  
Hiv 1

ABSTRACT Transcriptional transactivation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) promoter element by the essential viral Tat protein requires recruitment of positive transcription elongation factor b (P-TEFb) to the viral TAR RNA target. The recruitment of P-TEFb, which has been proposed to be necessary and sufficient for activation of viral gene expression, is mediated by the highly cooperative interaction of Tat and cyclin T1, an essential component of P-TEFb, with the HIV-1 TAR element. Species, such as rodents, that encode cyclin T1 variants that are unable to support TAR binding by the Tat-cyclin T1 heterodimer are also unable to support HIV-1 Tat function. In contrast, we here demonstrate that the bovine immunodeficiency virus (BIV) Tat protein is fully able to bind to BIV TAR both in vivo and in vitro in the absence of any cellular cofactor. Nevertheless, BIV Tat can specifically recruit cyclin T1 to the BIV TAR element, and this recruitment is as essential for BIV Tat function as it is for HIV-1 Tat activity. However, because the cyclin T1 protein does not contribute to TAR binding, BIV Tat is able to function effectively in cells from several species that do not support HIV-1 Tat function. Thus, BIV Tat, while apparently dependent on the same cellular cofactor as the Tat proteins encoded by other lentiviruses, is nevertheless unique in terms of the mechanism used to recruit the BIV Tat-cyclin T1 complex to the viral LTR promoter.

scholarly journals Molecular detection of bovine immunodeficiency virus (BIV) in bovines from the state of Minas Gerais, Brazil

2019 ◽  
Vol 71 (2) ◽  
pp. 711-714
Author(s):  
A.P.S. Rodrigues ◽  
A.A. Fonseca Júnior ◽  
G.K. Lima ◽  
J.M. Bicalho ◽  
R.C. Leite ◽  
...  
Keyword(s):  
Molecular Detection ◽  
Minas Gerais ◽  
The State ◽  
Bovine Immunodeficiency Virus ◽  
Immunodeficiency Virus

The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses

2004 ◽  
Vol 5 (2) ◽  
pp. 125-143 ◽  
Author(s):  
Marie-Claude St-Louis ◽  
Mihaela Cojocariu ◽  
Denis Archambault
Keyword(s):  
Gene Expression ◽  
Human Immunodeficiency Virus ◽  
Genomic Structure ◽  
Bovine Immunodeficiency Virus ◽  
Striking Similarity ◽  
Wasting Syndrome ◽  
Visna Virus ◽  
Immunodeficiency Virus ◽  
Viral Genes ◽  
Molecular Aspects

AbstractBovine immunodeficiency virus (BIV) was first isolated in 1969 from a cow, R-29, with a wasting syndrome. The virus isolated induced the formation of syncytia in cell cultures and was structurally similar to maedi-visna virus. Twenty years later, it was demonstrated that the bovine R-29 isolate was indeed a lentivirus with striking similarity to the human immunodeficiency virus. Like other lentiviruses, BIV has a complex genomic structure characterized by the presence of several regulatory/accessory genes that encode proteins, some of which are involved in the regulation of virus gene expression. This manuscript aims to review biological and, more particularly, molecular aspects of BIV, with emphasis on regulatory/accessory viral genes/proteins, in comparison with those of other lentiviruses.

Immune suppression in calves with bovine immunodeficiency virus.

1997 ◽  
Vol 4 (2) ◽  
pp. 232-235 ◽  
Author(s):  
S Zhang ◽  
C Wood ◽  
W Xue ◽  
S M Krukenberg ◽  
Q Chen ◽  
...  
Keyword(s):  
Immune Suppression ◽  
Bovine Immunodeficiency Virus ◽  
Immunodeficiency Virus

scholarly journals Construction and Molecular Analysis of Gene Transfer Systems Derived from Bovine Immunodeficiency Virus

2001 ◽  
Vol 75 (7) ◽  
pp. 3371-3382 ◽  
Author(s):  
Robert Berkowitz ◽  
Heini Ilves ◽  
Wei Yu Lin ◽  
Karl Eckert ◽  
Andrea Coward ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Target Cell ◽  
Expression System ◽  
Cell Types ◽  
Human Cells ◽  
Bovine Immunodeficiency Virus ◽  
Transduction Efficiency ◽  
Hematopoietic Stem ◽  
Immunodeficiency Virus ◽  
Immortalized Cell

ABSTRACT Because lentiviruses are able to infect nondividing cells, these viruses might be utilized in gene therapy applications where the target cell does not divide. However, it has been suggested that the introduction of primate lentivirus sequences, particularly those of human immunodeficiency virus, into human cells may pose a health risk for the patient. To avoid this concern, we have constructed gene transfer systems based on a nonprimate lentivirus, bovine immunodeficiency virus. A panel of vectors and packaging constructs was generated and analyzed in a transient expression system for virion production and maturation, vector expression and encapsidation, and envelope protein pseudotyping. Virion preparations were also analyzed for transduction efficiency in a panel of human and nonhuman primary cells and immortalized cell lines. The virion preparations transduced most of the target cell types, with efficiencies up to 90% and with titers of unconcentrated virus up to 5 × 105infectious doses/ml. In addition, infection of nondividing human cells, including unstimulated hematopoietic stem cells and irradiated endothelial cells, was observed.

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