scholarly journals Molecular characterization and phylogenetic analysis of oncogenes from virulent serotype-1 Marek's disease virus in India

2018 ◽  
Vol 62 (03) ◽  
pp. 277-286 ◽  
Author(s):  
Y. PRATHIBHA ◽  
B. SREEDEVI ◽  
N. VINOD KUMAR ◽  
CH. SRILATHA
Keyword(s):  
Phylogenetic Analysis ◽  
Molecular Characterization ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Serotype 1

Molecular characterization and phylogenetic analysis of a virulent Marek’s disease virus field strain in broiler chickens in Japan

2017 ◽  
Vol 47 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Hoda A. Abd-Ellatieff ◽  
Abdelrahman A. Abou Rawash ◽  
Hany F. Ellakany ◽  
Wael M. Goda ◽  
T. Suzuki ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Molecular Characterization ◽  
Disease Virus ◽  
Broiler Chickens ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Field Strain ◽  
Marek’S Disease Virus ◽  
Marek’S Disease

Detection and molecular characterization of a highly oncogenic Marek's disease virus from vaccinated hens in Turkey

2021 ◽  
Vol 65 (02) ◽  
pp. 212-220
Author(s):  
Hasan Abayli ◽  
Burak Karabulut ◽  
Remziye Ozbek ◽  
Hasan Ongor ◽  
Necati Timurkaan ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease

Expression of Marek's disease virus (MDV) serotype 2 gene which has partial homology with MDV serotype 1 pp38 gene

1995 ◽  
Vol 35 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Mitsuru Ono ◽  
Ken Maeda ◽  
Yasushi Kawaguchi ◽  
Hyung-Kwan Jang ◽  
Yukinobu Tohya ◽  
...  
Keyword(s):  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Serotype 1 ◽  
Pp38 Gene ◽  
Partial Homology

scholarly journals Genetic characterization of a Marek’s disease virus strain isolated in Japan

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Shiro Murata ◽  
Yuka Machida ◽  
Masayoshi Isezaki ◽  
Naoya Maekawa ◽  
Tomohiro Okagawa ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Disease Virus ◽  
Genomic Sequence ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Coding Region ◽  
Japanese Strain ◽  
Genetic Characteristics

Abstract Background Marek’s disease virus (MDV) causes malignant lymphomas in chickens (Marek’s disease, MD). MD is currently controlled by vaccination; however, MDV strains have a tendency to develop increased virulence. Distinct diversity and point mutations are present in the Meq proteins, the oncoproteins of MDV, suggesting that changes in protein function induced by amino acid substitutions might affect MDV virulence. We previously reported that recent MDV isolates in Japan display distinct mutations in Meq proteins from those observed in traditional MDV isolates in Japan, but similar to those in MDV strains isolated from other countries. Methods To further investigate the genetic characteristics in Japanese field strains, we sequenced the whole genome of an MDV strain that was successfully isolated from a chicken with MD in Japan. A phylogenetic analysis of the meq gene was also performed. Results Phylogenetic analysis revealed that the Meq proteins in most of the Japanese isolates were similar to those of Chinese and European strains, and the genomic sequence of the Japanese strain was classified into the Eurasian cluster. Comparison of coding region sequences among the Japanese strain and MDV strains from other countries revealed that the genetic characteristics of the Japanese strain were similar to those of Chinese and European strains. Conclusions The MDV strains distributed in Asian and European countries including Japan seem to be genetically closer to each other than to MDV strains from North America. These findings indicate that the genetic diversities of MDV strains that emerged may have been dependent on the different vaccination-based control approaches.

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