Major depressive episodes in clinical practice: the state of art and new developments in drug therapy

2011 ◽  
Author(s):  
Alessandro Colasanti ◽  
Allan H. Young
Keyword(s):  
Clinical Practice ◽  
Drug Therapy ◽  
The State ◽  
Major Depressive ◽  
New Developments ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
State Of Art

Platelet 3H-imipramine binding in major depressive episodes

1991 ◽  
Vol 6 (2) ◽  
pp. 73-78
Author(s):  
G Faludi ◽  
K Tekes
Keyword(s):  
Clinical Practice ◽  
Binding Sites ◽  
Biological Marker ◽  
Affinity Constant ◽  
Major Depressive ◽  
State Dependent ◽  
Imipramine Binding ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Age And Sex

SummaryDensity (Bmax) and affinity constant (Kd) values of tritiated imipramine binding sites were determined on platelets from patients suffering from major depression and from healthy, age-and sex-matched controls. Significantly lower Bmax values were found in the depressed patients, while the Kd values did not differ from those of controls. The results suggest that, in accordance with data from the literature, decrease in 3H-imipramine binding sites may be used as a state-dependent biological marker of depression in clinical practice.

Studies on the Psychosomatic Functioning of Ill-Health According to Eastern and Western Medicine 6.

2001 ◽  
Vol 29 (02) ◽  
pp. 247-264 ◽  
Author(s):  
Masashi Takeichi ◽  
Takeshi Sato ◽  
Masasuke Takefu
Keyword(s):  
Fractal Dimension ◽  
Medical Students ◽  
Preventive Treatment ◽  
The State ◽  
Major Depressive ◽  
Dsm Iv ◽  
Student’S T ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
The Relationship

In the accompanying paper "Psychosomatic Characteristics of Anxiety and the Anxiety Affinitive Constitution (Provisional Term) in Medical Students," we suggest that anassessment of the relationship between anxiety and the state of thoracic-abdominal balance of breathing, and the creation of an anxiety-affinitive constitution index (AACI) derived from that assessment, will be indispensable for furthering research in the future. Using the tenets of Oriental psychosomatic medicine, we examined in this research medical students (N = 104) from whom we had received fully-informed consent for the research in writing, and patients who met the DSM-IV diagnostic criteria for anxiety disorders (N = 18) and major depressive episodes (N = 20). We then identified their anxiety and depressive psychosomatic traits in accordance with an assessment of the relationship between anxiety and the state of their thoracic-abdominal balance of breathing, and the AACI derived from that assessment. We performed a multiple regression analysis with the STAI trait anxiety as the dependent variable, and the parameters of the somatic tests as the independent variables. We obtained the formula that AACI = - 62.9 + 72.9 × the thoracic/abdominal respiratory movement ratio (the fractal dimensionvalue for the thoracic respiratory curve/the fractal dimension value for the abdominal respiratory curve) + 22.5 × the horizontal eye movement (the fractal dimension value) + 2.4 × the dental indentation of the tongue (existence, 1; none 0). We then obtained data regarding a symptomatological, constitutional, and nosological diagnosis of anxiety and depression based on the AACI values of the Student's t test calculated for the medical students and the anxiety disorder patients with major depressive episodes, and a statistical analysis using ANOVA. We believe the AACI we created in this research will be very important and significant for the preventive treatment of lifestyle illnesses and stress-related diseases.

What is the role of conventional antidepressants in the treatment of major depressive episodes with Mixed Features Specifier?

CNS Spectrums ◽  
2016 ◽  
Vol 22 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Gianni L. Faedda ◽  
Ciro Marangoni
Keyword(s):  
Clinical Trials ◽  
Unipolar Depression ◽  
Preliminary Evidence ◽  
Major Depressive ◽  
Pharmacological Management ◽  
Diagnostic And Statistical Manual ◽  
Mixed Features ◽  
Effective Use ◽  
Major Depressive Episodes ◽  
Depressive Episodes

The newly introduced Mixed Features Specifier of Major Depressive Episode and Disorder (MDE/MDD) is especially challenging in terms of pharmacological management. Prior to the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of the mixed features specifier were intradepressive hypomanic symptoms, always and only associated with bipolar disorder (BD).Intradepressive hypomanic symptoms, mostly referred to as depressive mixed states (DMX), have been poorly characterized, and their treatment offers significant challenges. To understand the diagnostic context of DMX, we trace the nosological changes and collocation of intradepressive hypomanic symptoms, and examine diagnostic and prognostic implications of such mixed features.One of the reasons so little is known about the treatment of DMX is that depressed patients with rapid cycling, substance abuse disorder, and suicidal ideation/attempts are routinely excluded from clinical trials of antidepressants. The exclusion of DMX patients from clinical trials has prevented an assessment of the safety and tolerability of short- and long-term use of antidepressants. Therefore, the generalization of data obtained in clinical trials for unipolar depression to patients with intradepressive hypomanic features is inappropriate and methodologically flawed.A selective review of the literature shows that antidepressants alone have limited efficacy in DMX, but they have the potential to induce, maintain, or worsen mixed features during depressive episodes in BD. On the other hand, preliminary evidence supports the effective use of some atypical antipsychotics in the treatment of DMX.

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