scholarly journals Histopathological and microbiological findings in buffalo chronic mastitis: evidence of tertiary lymphoid structures

2019 ◽  
Vol 20 (3) ◽  
Author(s):  
Brunella Restucci ◽  
Ludovico Dipineto ◽  
Manuela Martano ◽  
Anna Balestrieri ◽  
Davide Ciccarelli ◽  
...  
Keyword(s):  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

scholarly journals Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Luuk van Hooren ◽  
Alessandra Vaccaro ◽  
Mohanraj Ramachandran ◽  
Konstantinos Vazaios ◽  
Sylwia Libard ◽  
...  
Keyword(s):  
Checkpoint Inhibitors ◽  
Systemic Delivery ◽  
Systemic Induction ◽  
T Cell Infiltration ◽  
Treatment Naïve ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures ◽  
Immunosuppressive Microenvironment ◽  
The Brain ◽  
Opening Up

AbstractGliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of αCD40 induces hypofunctional T cells and impairs the response to immune checkpoint inhibitors in pre-clinical glioma models. This is associated with a systemic induction of suppressive CD11b+ B cells post-αCD40 treatment, which accumulate in the tumor microenvironment. Our work unveils the pleiotropic effects of αCD40 therapy in glioma and reveals that immunotherapies can modulate TLS formation in the brain, opening up for future opportunities to regulate the immune response.

Characteristics of Tertiary Lymphoid Structures in Melanoma Skin Metastases Predict Overall Survival

2020 ◽  
Vol 231 (4) ◽  
pp. S264
Author(s):  
Kevin Tyler Lynch ◽  
Max Meneveau ◽  
Samuel Young ◽  
Nolan Wages ◽  
Craig Lee Slingluff ◽  
...  
Keyword(s):  
Overall Survival ◽  
Skin Metastases ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures ◽  
Melanoma Skin

scholarly journals Tertiary Lymphoid Structures Associate with Tumour Stage in Urothelial Bladder Cancer

2018 ◽  
Vol 4 (1) ◽  
pp. 137-137
Author(s):  
Madhuri Koti ◽  
Amanda Shuo Xu ◽  
Kevin Yi Mi Ren ◽  
Kash Visram ◽  
Runhan Ren ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumour Stage ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

Tertiary lymphoid structures correlate with better prognosis in cutaneous angiosarcoma

2021 ◽  
Author(s):  
Tetsuya Magara ◽  
Motoki Nakamura ◽  
Yuka Nojiri ◽  
Maki Yoshimitsu ◽  
Shinji Kano ◽  
...  
Keyword(s):  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures
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