scholarly journals Tissue distribution of marbofloxacin in pigs after a single intramuscular injection

2017 ◽  
Vol 18 (2) ◽  
pp. 169 ◽  
Author(s):  
Fan Yang ◽  
Yiming Liu ◽  
Zhili Li ◽  
Yuqin Wang ◽  
Baobao Liu ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Intramuscular Injection ◽  
Single Intramuscular Injection

THE EFFECT OF BETAMETHASONE ON GLUCOSE PRODUCTION AND ON GLUCONEOGENESIS FROM AMINO ACIDS IN SHEEP

1974 ◽  
Vol 60 (3) ◽  
pp. 455-461 ◽  
Author(s):  
P. E. B. REILLY ◽  
E. J. H. FORD
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Plasma Glucose ◽  
Intramuscular Injection ◽  
Significant Proportion ◽  
Glucose Production ◽  
Entry Rate ◽  
Steroid Administration ◽  
Single Intramuscular Injection ◽  
Mean Glucose

SUMMARY Primed continuous infusions of tracer amounts of [U-14C]glucose and of [U-14C]labelled mixed amino acids were used to measure plasma glucose and amino acid entry rates and to obtain an index of the incorporation of amino acid carbon into glucose by sheep before and 24 h after a single intramuscular injection of betamethasone. Maximum hyperglycaemia occurred 24 h after administration of the steroid, but there was no significant change in arterial amino acid concentration. Mean glucose entry rate was significantly raised 24 h after steroid administration. The rate of incorporation of amino acid carbon into glucose also increased significantly. The increases in plasma glucose concentration and in glucose entry confirm the authors' previous results. The results also indicate that a significant proportion of the additional glucose entry is synthesized from amino acid carbon.

Kanamycin in the Treatment of Gonorrhoea in the Female

1969 ◽  
Vol 14 (5) ◽  
pp. 176-179 ◽  
Author(s):  
M. I. McGill ◽  
M. Moffett ◽  
G. Masterton ◽  
C. B. S. Schofield
Keyword(s):  
Statistical Analysis ◽  
Toxic Effect ◽  
Intramuscular Injection ◽  
Female Patients ◽  
Injection Treatment ◽  
Single Intramuscular Injection

When penicillin cannot be used in the treatment of gonorrhoea the lack of another form of therapy which is efficient, rapid and by injection is a serious problem. This paper attempts to assess the claims of kanamycin sulphate to fill this role. One hundred consecutive female patients suffering from gonorrhoea were treated with a single intramuscular injection of 2 g. kanamycin without any toxic effect. Normal statistical analysis was not possible because of the problem of the defaulting patient, but the results obtained compare favourably with those achieved by the more familiar penicillin regimes. Accordingly, we believe that kanamycin is a useful addition to the drugs already available for the treatment of gonorrhoea, especially as an alternative injection treatment when penicillin is contra-indicated or has already failed, and furthermore, it does not mask incubating syphilis.

Comparative Value of Three Sources of Vitamins A and D for Fattening Pigs

1954 ◽  
Vol 1954 ◽  
pp. 45-47
Author(s):  
R. S. Barber ◽  
R. Braude ◽  
M. E. Coates ◽  
G. F. Harrison ◽  
K. G. Mitchell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Intramuscular Injection ◽  
Fish Meal ◽  
List Type ◽  
Cod Liver Oil ◽  
Commercial Preparation ◽  
Single Intramuscular Injection ◽  
Fattening Pigs

The efficacy of three sources of vitamins A and D supplements was tested in an experiment with fattening pigs involving the following four treatments :(1) Control—basal meal.(2) As control, but at one week of age the pigs had been given a single intramuscular injection of a commercial preparation, supplying 500,000 i.u. of vitamin A and 100,000 i.u. of vitamin D3.(3) Basal meal + 1 % cod-liver oil (containing 500 i.u./g. of vitamin A and 68 i.u./g. of vitamin 3), supplying 2,270 i.u. of vitamin A and 309 i.u. of vitamin D3 per lb. of diet.(4) Basal meal + synthetic vitamins A and D concentrate (containing 50,000 i.u./g. of vitamin A and 5,000 i.u./g. of vitamin D3), added to supply 2,250 i.u. of vitamin A and 300 i.u. of vitamin D3 per lb. of diet.The basal meal which was the standard fattening diet used at Shinfield consisted of: fine miller’s offal 50, barley meal 30, flaked maize 10, white fish meal 10, all parts by weight. It should be noted that the diet contained a precursor of vitamin A, and it was calculated that this would provide about one-third of the recommended allowance of vitamin A for fattening pigs.

scholarly journals Hydroxocobalamin. I. Blood Levels and Urinary Excretion of Vitamin B12 in Man After a Single Parenteral Dose of Aqueous Hydroxocobalamin, Aqueous Cyanocobalamin and Cyanocobalamin Zinc-Tannate Complex

Blood ◽  
1961 ◽  
Vol 18 (5) ◽  
pp. 511-521 ◽  
Author(s):  
GEORGE B. JERZY GLASS ◽  
HELEN R. SKEGGS ◽  
DUK HO LEE ◽  
E. LINN JONES ◽  
WILLIAM W. HARDY
Keyword(s):  
Urinary Excretion ◽  
Vitamin B12 ◽  
Blood Level ◽  
Intramuscular Injection ◽  
Serum Vitamin ◽  
Blood Levels ◽  
Parenteral Dose ◽  
Single Intramuscular Injection

Abstract A single intramuscular injection of 500 or 1000 µg. of hydroxocobalamin to 17 individuals resulted in a 1.8- to 4.1-times higher mean serum vitamin B12 blood level, respectively, 5 hours after injection; a 4.6- and 12.8-times higher level 24 hours after injection; a 2.4- and 5.2-times higher level 72 hours after injection, and a 1.6- and 2.4-times higher level by the 2nd through the 4th week after injection than identical doses of cyanocobalamin administered to 19 individuals. The vitamin B12 blood levels following i.m. administration of 500 or 1000 µg. of hydroxocobalamin were significantly higher during the first 24 and 48 hours, respectively, than they were after a cyanocobalamin zinc-tannate complex given to 17 individuals at identical doses. After a single i.m. injection of 500 or 1000 µg. of hydroxocobalamin, an average of only 16 per cent and 27 per cent, respectively, of the vitamin B12 was lost in the 72-hour urines, as compared to 60 per cent and 69 per cent, respectively, after identical doses of cyanocobalamin. These differences, again, were highly significant statistically. The results of these studies give evidence of a slower rate of urinary excretion of hydroxocobalamin as compared to that of cyanocobalamin, and of its ability to build up consistently higher and more prolonged vitamin B12 levels in the blood.

scholarly journals Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

2019 ◽  
Vol 60 (3) ◽  
pp. 308-317 ◽  
Author(s):  
Michael R Landauer ◽  
Adam J Harvey ◽  
Michael D Kaytor ◽  
Regina M Day
Keyword(s):  
Estrogen Receptor ◽  
Mechanism Of Action ◽  
Total Body Irradiation ◽  
Intramuscular Injection ◽  
Acute Radiation ◽  
Beta Agonist ◽  
Therapeutic Window ◽  
Acute Radiation Syndrome ◽  
Single Intramuscular Injection ◽  
Total Body

Abstract There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic–acute radiation syndrome (H-ARS). A suspension of synthetic genistein nanoparticles was previously shown to be an effective radioprotectant against H-ARS when administered prior to exposure to a lethal dose of total body radiation. Here we aimed to determine the time to protection and the duration of protection when the genistein nanosuspension was administered by intramuscular injection, and we also investigated the drug’s mechanism of action. A single intramuscular injection of the genistein nanosuspension was an effective radioprotectant when given prophylactically 48 h to 12 h before irradiation, with maximum effectiveness occurring when administered 24 h before. No survival advantage was observed in animals administered only a single dose of drug after irradiation. The dose reduction factor of the genistein nanosuspension was determined by comparing the survival of treated and untreated animals following different doses of total body irradiation. As genistein is a selective estrogen receptor beta agonist, we also explored whether this was a central component of its radioprotective mechanism of action. Mice that received an intramuscular injection of an estrogen receptor antagonist (ICI 182,780) prior to administration of the genistein nanosuspension had significantly lower survival following total body irradiation compared with animals only receiving the nanosuspension (P < 0.01). These data define the time to and duration of radioprotection following a single intramuscular injection of the genistein nanosuspension and identify its likely mechanism of action.

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